Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA

  • Authors:
    • Yu-Xia Wang
    • Wei-Jie Zhu
    • Bao-Guo Xie
  • View Affiliations

  • Published online on: January 14, 2014     https://doi.org/10.3892/mmr.2014.1895
  • Pages: 889-893
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Abstract

The objective of this study was to investigate the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) in adipose tissue of the rat model of polycystic ovary syndrome (PCOS), induced by dehydroepiandrosterone (DHEA). Sixteen sexually immature Sprague-Dawley female rats were randomly assigned to the DHEA (n=8) or control (n=8) group. Adipose tissue was collected from the two rat groups following subcutaneous injection of DHEA in the DHEA group and a standard laboratory diet in the control group for 20 consecutive days. Reverse transcription polymerase chain reaction and western blot analysis were performed to detect expression of PPAR-γ at the mRNA and protein level in the adipose tissue. Both PPAR-γ mRNA and protein levels were decreased in the adipose tissue of DHEA‑induced PCOS rats compared to the control group. This decrease was significant (P<0.01). These results suggest that the pathogenesis of PCOS, which shares a number of common features with hyperandrogenemia, may involve the lipid metabolism pathway through inhibition of PPAR-γ.
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2014-March
Volume 9 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang Y, Zhu W and Xie B: Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA. Mol Med Rep 9: 889-893, 2014.
APA
Wang, Y., Zhu, W., & Xie, B. (2014). Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA. Molecular Medicine Reports, 9, 889-893. https://doi.org/10.3892/mmr.2014.1895
MLA
Wang, Y., Zhu, W., Xie, B."Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA". Molecular Medicine Reports 9.3 (2014): 889-893.
Chicago
Wang, Y., Zhu, W., Xie, B."Expression of PPAR-γ in adipose tissue of rats with polycystic ovary syndrome induced by DHEA". Molecular Medicine Reports 9, no. 3 (2014): 889-893. https://doi.org/10.3892/mmr.2014.1895