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Article

Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress

  • Authors:
    • Li‑Li Ji
    • Lei Tong
    • Jun‑Bo Peng
    • Xue‑Hua Jin
    • Dan Wei
    • Bao‑Ku Xu
    • Zhen‑Yu Wang
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 1165-1170
    |
    Published online on: February 7, 2014
       https://doi.org/10.3892/mmr.2014.1934
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Abstract

Vitamin D signaling not only controls calcium (Ca2+) and phosphorus uptake and transport, but also correlates with neurocognitive decline and neurodegenerative diseases. Almost all actions of Vitamin D are mediated by the transcription factor, vitamin D receptor (VDR), which has been widely identified in the central nervous system. Although previous studies have substantially advanced the understanding of the action of VDR in the brain, much remains unknown concerning how VDR relates to stress. Multiple lines of evidence indicate that the downregulation of L‑type voltage‑sensitive Ca2+‑channels α‑1C (LVSCC‑A1C) by vitamin D in hippocampal neurons is able to reduce the influx and excitotoxic effects of Ca2+ to neurons. Along these lines, the purpose of the present study was to analyze the relative expression of VDR in the hippocampus of rats exposed to single prolonged stress (SPS) as a putative animal model for human post‑traumatic stress disorder (PTSD). Furthermore, changes in the levels of expression of LVSCC‑A1C and Ca2+ (neurotransmitter content) were examined during the onset periods of PTSD. The results revealed an increase in the expression of VDR at 1, 3 and 7 days post‑stress compared with the control group. The intracellular free Ca2+ levels in the hippocampus increased 1 day after SPS exposure, and then decreased gradually to the normal level at 14 days, consistent with the expression pattern of LVSCC‑A1C. These results indicated that VDR may be involved in the pathogenesis of SPS rats, thereby providing an alternative preparation to search for optimal therapeutic strategies for PTSD.
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1 

Liberzon I and Young EA: Effects of stress and glucocorticoids on CNS oxytocin receptor binding. Psychoneuroendocrinology. 22:411–422. 1997. View Article : Google Scholar : PubMed/NCBI

2 

Khan S and Liberzon I: Topiramate attenuates exaggerated acoustic startle in an animal model of PTSD. Psychopharmacology (Berl). 172:225–229. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Iwamoto Y, Morinobu S, Takahashi T and Yamawaki S: Single prolonged stress increases contextual freezing and the expression of glycine transporter 1 and vesicle-associated membrane protein 2 mRNA in the hippocampus of rats. Prog Neuropsychopharmacol Biol Psychiatry. 31:642–651. 2007. View Article : Google Scholar

4 

Joëls M: Functional actions of corticosteroids in the hippocampus. Eur J Pharmacol. 583:312–321. 2008.

5 

Buell JS and Dawson-Hughes B: Vitamin D and neurocognitive dysfunction: preventing ‘D’ecline? Mol Aspects Med. 29:415–422. 2008.PubMed/NCBI

6 

Kalueff AV and Tuohimaa P: Neurosteroid hormone vitamin D and its utility in clinical nutrition. Curr Opin Clin Nutr Metab Care. 10:12–19. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Bartoccini E, Marini F, Damaskopoulou E, et al: Nuclear lipid microdomains regulate nuclear vitamin D3 uptake and influence embryonic hippocampal cell differentiation. Mol Biol Cell. 22:3022–3031. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Pike JW and Meyer MB: The vitamin D receptor: new paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D(3). Endocrinol Metab Clin North Am. 39:255–269. 2010. View Article : Google Scholar

9 

Freeman MR, Cinar B, Kim J, et al: Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes. Steroids. 72:210–217. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Marini F, Bartoccini E, Cascianelli G, et al: Effect of 1alpha,25-dihydroxyvitamin D3 in embryonic hippocampal cells. Hippocampus. 20:696–705. 2010.PubMed/NCBI

11 

Kuningas M, Mooijaart SP, Jolles J, Slagboom PE, Westendorp RG and van Heemst D: VDR gene variants associate with cognitive function and depressive symptoms in old age. Neurobiol Aging. 30:466–473. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Burne TH, Johnston AN, McGrath JJ and Mackay-Sim A: Swimming behaviour and post-swimming activity in Vitamin D receptor knockout mice. Brain Res Bull. 69:74–78. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Kalueff AV, Lou YR, Laaksi I and Tuohimaa P: Increased anxiety in mice lacking vitamin D receptor gene. Neuroreport. 15:1271–1274. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Sutherland MK, Somerville MJ, Yoong LK, Bergeron C, Haussler MR and McLachlan DR: Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: correlation with calbindin-28k mRNA levels. Brain Res Mol Brain Res. 13:239–250. 1992. View Article : Google Scholar : PubMed/NCBI

15 

Langub MC, Herman JP, Malluche HH and Koszewski NJ: Evidence of functional vitamin D receptors in rat hippocampus. Neuroscience. 104:49–56. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Thibault O, Pancani T, Landfield PW and Norris CM: Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer’s disease. Biochim Biophys Acta. 1822:546–549. 2012.PubMed/NCBI

17 

Takahashi T, Morinobu S, Iwamoto Y and Yamawaki S: Effect of paroxetine on enhanced contextual fear induced by single prolonged stress in rats. Psychopharmacology (Berl). 189:165–173. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Liberzon I, Krstov M and Young EA: Stress-restress: effects on ACTH and fast feedback. Psychoneuroendocrinology. 22:443–453. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Stumpf WE, Sar M, Clark SA and DeLuca HF: Brain target sites for 1,25-dihydroxyvitamin D3. Science. 215:1403–1405. 1982. View Article : Google Scholar : PubMed/NCBI

20 

Eyles DW, Smith S, Kinobe R, Hewison M and McGrath JJ: Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat. 29:21–30. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Kiraly SJ, Kiraly MA, Hawe RD and Makhani N: Vitamin D as a neuroactive substance: review. Scientific World Journal. 6:125–139. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Oudshoorn C, Mattace-Raso FU, van der Velde N, Colin EM and van der Cammen TJ: Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer’s disease. Dement Geriatr Cogn Disord. 25:539–543. 2008.PubMed/NCBI

23 

Obradovic D, Gronemeyer H, Lutz B and Rein T: Cross-talk of vitamin D and glucocorticoids in hippocampal cells. J Neurochem. 96:500–509. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Minasyan A, Keisala T, Lou YR, Kalueff AV and Tuohimaa P: Neophobia, sensory and cognitive functions, and hedonic responses in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol. 104:274–280. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Bouillon R, Carmeliet G, Daci E, Segaert S and Verstuyf A: Vitamin D metabolism and action. Osteoporos Int. 8(Suppl 2): S13–S19. 1998. View Article : Google Scholar

26 

Brewer LD, Thibault V, Chen KC, Langub MC, Landfield PW and Porter NM: Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J Neurosci. 21:98–108. 2001.PubMed/NCBI

27 

Brewer LD, Porter NM, Kerr DS, Landfield PW and Thibault O: Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+-mediated hippocampal biomarkers of aging. Cell Calcium. 40:277–286. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Brown J, Bianco JI, McGrath JJ and Eyles DW: 1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neurosci Lett. 343:139–143. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Cornet A, Baudet C, Neveu I, Baron-Van Evercooren A, Brachet P and Naveilhan P: 1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro. J Neurosci Res. 53:742–746. 1998. View Article : Google Scholar : PubMed/NCBI

30 

Neveu I, Naveilhan P, Jehan F, et al: 1,25-dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells. Brain Res Mol Brain Res. 24:70–76. 1994. View Article : Google Scholar : PubMed/NCBI

31 

Dursun E, Gezen-Ak D and Yilmazer S: A novel perspective for Alzheimer’s disease: vitamin D receptor suppression by amyloid-β and preventing the amyloid-β induced alterations by vitamin D in cortical neurons. J Alzheimers Dis. 23:207–219. 2011.

32 

Taniura H, Ito M, Sanada N, et al: Chronic vitamin D3 treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons. J Neurosci Res. 83:1179–1189. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Almeras L, Eyles D, Benech P, et al: Developmental vitamin D deficiency alters brain protein expression in the adult rat: implications for neuropsychiatric disorders. Proteomics. 7:769–780. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Eyles D, Almeras L, Benech P, et al: Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brain. J Steroid Biochem Mol Biol. 103:538–545. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Cantorna MT, Hayes CE and DeLuca HF: 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc Natl Acad Sci USA. 93:7861–7864. 1996. View Article : Google Scholar : PubMed/NCBI

36 

Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F and Wion D: New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab. 13:100–105. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Lansdowne AT and Provost SC: Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl). 135:319–323. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Przybelski RJ and Binkley NC: Is vitamin D important for preserving cognition? A positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function. Arch Biochem Biophys. 460:202–205. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Wilkins CH, Sheline YI, Roe CM, Birge SJ and Morris JC: Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry. 14:1032–1040. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Eyles D, Brown J, Mackay-Sim A, McGrath J and Feron F: Vitamin D3 and brain development. Neuroscience. 118:641–653. 2003. View Article : Google Scholar

41 

Becker A, Eyles DW, McGrath JJ and Grecksch G: Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats. Behav Brain Res. 161:306–312. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Bergh JJ, Shao Y, Puente E, Duncan RL and Farach-Carson MC: Osteoblast Ca(2+) permeability and voltage-sensitive Ca(2+) channel expression is temporally regulated by 1,25-dihydroxyvitamin D(3). Am J Physiol Cell Physiol. 290:C822–C831. 2006.

43 

Naveilhan P, Neveu I, Wion D and Brachet P: 1,25-Dihydroxyvitamin D3, an inducer of glial cell line-derived neurotrophic factor. Neuroreport. 7:2171–2175. 1996. View Article : Google Scholar : PubMed/NCBI

44 

Thibault O, Gant JC and Landfield PW: Expansion of the calcium hypothesis of brain aging and Alzheimer’s disease: minding the store. Aging Cell. 6:307–317. 2007.PubMed/NCBI

45 

Xiao B, Yu B, Wang HT, Han F and Shi YX: Single-prolonged stress induces apoptosis by activating cytochrome C/caspase-9 pathway in a rat model of post-traumatic stress disorder. Cell Mol Neurobiol. 31:37–43. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Sattler R and Tymianski M: Molecular mechanisms of calcium-dependent excitotoxicity. J Mol Med (Berl). 78:3–13. 2000. View Article : Google Scholar

47 

Arundine M and Tymianski M: Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium. 34:325–337. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Thibault O, Hadley R and Landfield PW: Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity. J Neurosci. 21:9744–9756. 2001.

49 

Veng LM, Mesches MH and Browning MD: Age-related working memory impairment is correlated with increases in the L-type calcium channel protein alpha1D (Cav1.3) in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment. Brain Res Mol Brain Res. 110:193–202. 2003. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ji LL, Tong L, Peng JB, Jin XH, Wei D, Xu BK and Wang ZY: Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress. Mol Med Rep 9: 1165-1170, 2014.
APA
Ji, L., Tong, L., Peng, J., Jin, X., Wei, D., Xu, B., & Wang, Z. (2014). Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress. Molecular Medicine Reports, 9, 1165-1170. https://doi.org/10.3892/mmr.2014.1934
MLA
Ji, L., Tong, L., Peng, J., Jin, X., Wei, D., Xu, B., Wang, Z."Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress". Molecular Medicine Reports 9.4 (2014): 1165-1170.
Chicago
Ji, L., Tong, L., Peng, J., Jin, X., Wei, D., Xu, B., Wang, Z."Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress". Molecular Medicine Reports 9, no. 4 (2014): 1165-1170. https://doi.org/10.3892/mmr.2014.1934
Copy and paste a formatted citation
x
Spandidos Publications style
Ji LL, Tong L, Peng JB, Jin XH, Wei D, Xu BK and Wang ZY: Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress. Mol Med Rep 9: 1165-1170, 2014.
APA
Ji, L., Tong, L., Peng, J., Jin, X., Wei, D., Xu, B., & Wang, Z. (2014). Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress. Molecular Medicine Reports, 9, 1165-1170. https://doi.org/10.3892/mmr.2014.1934
MLA
Ji, L., Tong, L., Peng, J., Jin, X., Wei, D., Xu, B., Wang, Z."Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress". Molecular Medicine Reports 9.4 (2014): 1165-1170.
Chicago
Ji, L., Tong, L., Peng, J., Jin, X., Wei, D., Xu, B., Wang, Z."Changes in the expression of the vitamin D receptor and LVSCC‑A1C in the rat hippocampus submitted to single prolonged stress". Molecular Medicine Reports 9, no. 4 (2014): 1165-1170. https://doi.org/10.3892/mmr.2014.1934
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