GPC5, a tumor suppressor, is regulated by miR‑620 in lung adenocarcinoma

  • Authors:
    • Zhengyuan Zhao
    • Chengguang Han
    • Juntao Liu
    • Changlei Wang
    • Yi Wang
    • Liya Cheng
  • View Affiliations

  • Published online on: March 28, 2014     https://doi.org/10.3892/mmr.2014.2092
  • Pages: 2540-2546
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Abstract

In the current study, a proportion of lung adenocarcinoma was shown to reduce GPC5 expression in the absence of transcriptional silencing of the tumor suppressor gene, GPC5, by aberrant methylation of CpG islands. It was hypothesized that the loss of GPC5 expression is associated with upregulation of miR‑620 in human lung adenocarcinoma tissue compared with the matched normal lung tissue. The downregulation of GPC5 in lung adenocarcinoma cell lines is regulated by miR‑620 through binding of the 3'‑untranslated region. Furthermore, blockage of miR‑620 inhibited the proliferation, migration and invasion of lung adenocarcinoma cells by directly regulating GPC5, and GPC5 knockdown eliminates this phenotype. These results provided a novel insight into the mechanism of miRNA regulation in lung adenocarcinoma.
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June-2014
Volume 9 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao Z, Han C, Liu J, Wang C, Wang Y and Cheng L: GPC5, a tumor suppressor, is regulated by miR‑620 in lung adenocarcinoma. Mol Med Rep 9: 2540-2546, 2014
APA
Zhao, Z., Han, C., Liu, J., Wang, C., Wang, Y., & Cheng, L. (2014). GPC5, a tumor suppressor, is regulated by miR‑620 in lung adenocarcinoma. Molecular Medicine Reports, 9, 2540-2546. https://doi.org/10.3892/mmr.2014.2092
MLA
Zhao, Z., Han, C., Liu, J., Wang, C., Wang, Y., Cheng, L."GPC5, a tumor suppressor, is regulated by miR‑620 in lung adenocarcinoma". Molecular Medicine Reports 9.6 (2014): 2540-2546.
Chicago
Zhao, Z., Han, C., Liu, J., Wang, C., Wang, Y., Cheng, L."GPC5, a tumor suppressor, is regulated by miR‑620 in lung adenocarcinoma". Molecular Medicine Reports 9, no. 6 (2014): 2540-2546. https://doi.org/10.3892/mmr.2014.2092