Cryptotanshinone inhibits lung tumorigenesis and induces apoptosis in cancer cells in vitro and in vivo

Chen,Liang; Wang,Hui-Juan; Xie,Wenli; Yao,Yunyi; Zhang,Yan-Shan; Wang,Huiling

doi:10.3892/mmr.2014.2093

Cryptotanshinone inhibits lung tumorigenesis and induces apoptosis in cancer cells in vitro and in vivo

Authors:
- Liang Chen
- Hui-Juan Wang
- Wenli Xie
- Yunyi Yao
- Yan-Shan Zhang
- Huiling Wang
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Affiliations: Department of Respiratory Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Department of Tumor Chemotherapy, Wuwei Tumor Hospital, Wuwei, Gansu 733000, P.R. China, Department of Cardiology, The Second Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, P.R. China, Department of Tumor Surgery, Wuwei Tumor Hospital, Wuwei, Gansu 733000, P.R. China
Published online on: March 31, 2014 https://doi.org/10.3892/mmr.2014.2093
Pages: 2447-2452

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Abstract

Cryptotanshinone is one of the compounds extracted from the root of Salvia miltiorrhiza Bunge. Unlike other tanshinones, only a small number of studies have focused on cryptotanshinone for medical treatment. In the present study, the A549 lung cancer cell line and xenograft models of human lung tumors were used to assess the anti‑cancer effect of cryptotanshinone. The effect of cryptotanshinone on human lung cancer, including growth inhibition, cell cycle arrest and apoptosis factors, were identified in vitro, and inhibition of tumor formation, improvement of body condition as well as pathological apoptotic effects were detected in vivo. These results suggested that cryptotanshinone is a potential drug for the treatment and prevention of human lung cancer.

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