Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma

Wang,Xuanwei; Du,Jingyu; Gu,Pengcheng; Jin,Rilong; Lin,Xiangjin

doi:10.3892/mmr.2014.2110

Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma

Authors:
- Xuanwei Wang
- Jingyu Du
- Pengcheng Gu
- Rilong Jin
- Xiangjin Lin
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Affiliations: Department of Orthopedics, the First Affiliated Hospital, Zhejianåg University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China
Published online on: April 2, 2014 https://doi.org/10.3892/mmr.2014.2110
Pages: 2105-2110
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

The prognosis of patients with osteosarcoma with distant metastasis and local recurrence remains poor. Increased expression of polymeric immunoglobulin receptor (pIgR) in tumor tissue has been detected in various types of cancer. However, the clinical significance of pIgR in osteosarcoma has yet to be elucidated. The present study aimed to investigate the prognostic value of pIgR in patients with osteosarcoma following surgical resection. pIgR expression was assessed using quantitative polymerase chain reaction analysis in cryopreserved osteosarcoma tissues from 22 patients, as well as using immunohistochemistry in paraffin‑embedded osteosarcoma tissues from 136 patients. The association between pIgR expression, clinicopathological factors and long‑term prognosis was retrospectively examined in these 136 patients. The prognostic significance of negative or positive pIgR expression in osteosarcoma was assessed using Kaplan‑Meier survival analysis and log‑rank tests. Univariate analysis indicated that patients with positive pIgR osteosarcoma tissue expression had a significantly worse overall survival (OS) compared with patients with negative pIgR osteosarcoma expression. Multivariate analysis revealed that positive pIgR expression in osteosarcoma tissues was an independent prognostic factor for OS following surgical resection (P<0.001). Furthermore, positive pIgR expression was significantly associated with poor prognosis in patients with osteosarcoma. These findings indicate that pIgR may be a novel predictor for poor prognosis in patients with osteosarcoma following surgical resection.

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