Prognostic value of PPM1D in 800 gastric cancer patients

  • Authors:
    • Dan Ma
    • Chao-Jun Zhang
    • Zu-Lin Chen
    • Hua Yang
  • View Affiliations

  • Published online on: April 24, 2014     https://doi.org/10.3892/mmr.2014.2165
  • Pages: 191-194
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Abstract

Protein phosphatase magnesium‑dependent 1 delta (PPM1D) has recently been associated with tumor biology. However, the expression pattern and clinical significance of PPM1D in gastric cancer (GC) have yet to be elucidated. The present study aimed to investigate the clinical and prognostic significance of PPM1D in GC. PPM1D expression was assessed in 800 patients with GC using immunohistochemistry and tissue samples were divided into a PPM1D‑positive and ‑negative group. The correlation between PPM1D expression and clinicopathological parameters or prognosis was investigated. PPM1D expression was significantly higher in GC tissue than in adjacent normal tissue (48 versus 9.5%; P<0.001). PPM1D positivity was significantly correlated with nodal status, distant metastasis and vascular invasion. Survival analysis indicated that the five‑year survival rate in the PPM1D‑positive group was significantly lower than that in the PPM1D‑negative group (41 versus 72%; p=0.0012). Furthermore, the association between PPM1D positivity and survival rate was still significant following regulation of other prognostic markers in a multivariate analysis [hazard ratio (HR), 6.572; 95% confidence interval (CI), 3.108‑13.471; P=0.0018]. In conclusion, the present study suggested that PPM1D positivity is associated with GC invasion and metastasis, and proposed PPM1D positivity as an indicator of unfavorable prognosis in patients with GC.
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July-2014
Volume 10 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Ma D, Zhang C, Chen Z and Yang H: Prognostic value of PPM1D in 800 gastric cancer patients. Mol Med Rep 10: 191-194, 2014
APA
Ma, D., Zhang, C., Chen, Z., & Yang, H. (2014). Prognostic value of PPM1D in 800 gastric cancer patients. Molecular Medicine Reports, 10, 191-194. https://doi.org/10.3892/mmr.2014.2165
MLA
Ma, D., Zhang, C., Chen, Z., Yang, H."Prognostic value of PPM1D in 800 gastric cancer patients". Molecular Medicine Reports 10.1 (2014): 191-194.
Chicago
Ma, D., Zhang, C., Chen, Z., Yang, H."Prognostic value of PPM1D in 800 gastric cancer patients". Molecular Medicine Reports 10, no. 1 (2014): 191-194. https://doi.org/10.3892/mmr.2014.2165