Th17 cells are associated with the Th1/Th2‑cell balance during Echinococcus multilocularis infection

  • Authors:
    • Xiumin Ma
    • Liang Wang
    • Hui Zhao
    • Nannan Pang
    • Fengbo Zhang
    • Tao Jiang
    • Xuelei Liu
    • Wulamu Mamuti
    • Hao Wen
    • Jianbing Ding
  • View Affiliations

  • Published online on: April 24, 2014     https://doi.org/10.3892/mmr.2014.2170
  • Pages: 236-240
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Abstract

The present study investigated the immunopathological effect of Echinococcus multilocularis (Em) using cytokine detection. Expression of the T‑helper (Th) 17‑cytokine, interleukin 17 (IL‑17), was observed using immunohistochemical staining, and levels of cytokines, including IL‑17, transforming growth factor β1 (TGF‑β1), IL‑6, interferon γ (IFN‑γ) and IL‑4, were assessed using ELISA at different stages of infection. IL‑17 expression occurred in hepatic cells at 1 month post‑infection, reached a maximum at 3 months post‑infection and then decreased gradually. Compared with the uninfected control, levels of the cytokines IL‑17, TGF‑β1, IL‑6, IFN‑γ and IL‑4 exhibited different dynamic patterns when infected with Em. In the immune response during the whole infection period, Th17 cells play an important role by secreting IL‑17, which may be involved in the Th1/Th2‑cell balance during the immune response. Th17 cells are associated with immunopathology in Em infection.
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July-2014
Volume 10 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Ma X, Wang L, Zhao H, Pang N, Zhang F, Jiang T, Liu X, Mamuti W, Wen H, Ding J, Ding J, et al: Th17 cells are associated with the Th1/Th2‑cell balance during Echinococcus multilocularis infection. Mol Med Rep 10: 236-240, 2014
APA
Ma, X., Wang, L., Zhao, H., Pang, N., Zhang, F., Jiang, T. ... Ding, J. (2014). Th17 cells are associated with the Th1/Th2‑cell balance during Echinococcus multilocularis infection. Molecular Medicine Reports, 10, 236-240. https://doi.org/10.3892/mmr.2014.2170
MLA
Ma, X., Wang, L., Zhao, H., Pang, N., Zhang, F., Jiang, T., Liu, X., Mamuti, W., Wen, H., Ding, J."Th17 cells are associated with the Th1/Th2‑cell balance during Echinococcus multilocularis infection". Molecular Medicine Reports 10.1 (2014): 236-240.
Chicago
Ma, X., Wang, L., Zhao, H., Pang, N., Zhang, F., Jiang, T., Liu, X., Mamuti, W., Wen, H., Ding, J."Th17 cells are associated with the Th1/Th2‑cell balance during Echinococcus multilocularis infection". Molecular Medicine Reports 10, no. 1 (2014): 236-240. https://doi.org/10.3892/mmr.2014.2170