Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes

  • Authors:
    • Guangfeng Xu
    • Chunmei Shi
    • Chenbo Ji
    • Guixian Song
    • Ling Chen
    • Lei Yang
    • Yaping Zhao
    • Xirong Guo
  • View Affiliations

  • Published online on: May 2, 2014     https://doi.org/10.3892/mmr.2014.2204
  • Pages: 223-228
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

MicroRNAs (miRNAs) are short non-coding RNAs that are involved in numerous biological processes, including obesity and insulin resistance. miR-26b is an obesity-related intronic miRNA located in the intron of the carboxy‑terminal domain, RNA polymerase II, polypeptide A, small phosphatase 1 gene. miR-26b is abundantly expressed in mice and mature human adipocytes, and is associated with the expression of adipokines. In the present study, the effects of energy-source materials and hormones associated with obesity, on miR-26b expression were investigated. It was demonstrated that free fatty acids (FFAs), glucose, glucocorticoids and growth hormone (GH) downregulate the expression of miR-26b in human adipocytes. The results indicate that the expression of miR-26b is affected by a variety of factors that are correlated with obesity and insulin sensitivity. Therefore, miR-26b may be an important mediator in the development of obesity‑associated insulin resistance.
View Figures
View References

Related Articles

Journal Cover

July-2014
Volume 10 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xu G, Shi C, Ji C, Song G, Chen L, Yang L, Zhao Y and Guo X: Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes. Mol Med Rep 10: 223-228, 2014.
APA
Xu, G., Shi, C., Ji, C., Song, G., Chen, L., Yang, L. ... Guo, X. (2014). Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes. Molecular Medicine Reports, 10, 223-228. https://doi.org/10.3892/mmr.2014.2204
MLA
Xu, G., Shi, C., Ji, C., Song, G., Chen, L., Yang, L., Zhao, Y., Guo, X."Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes". Molecular Medicine Reports 10.1 (2014): 223-228.
Chicago
Xu, G., Shi, C., Ji, C., Song, G., Chen, L., Yang, L., Zhao, Y., Guo, X."Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes". Molecular Medicine Reports 10, no. 1 (2014): 223-228. https://doi.org/10.3892/mmr.2014.2204