Differential expression of stromal aromatase in obese females is regulated by DNA methylation

  • Authors:
    • Xian‑Cheng Zeng
    • Xiang Ao
    • Hai‑Feng Yang
    • Guang‑Xian  Zhang
    • Wen‑Hong Li
    • Qi‑Long Liu
    • Yue‑Liang Tang
    • Yi‑Cheng Xie
    • Wen‑Guang  He
    • Yan‑Nian Huang
    • Lei Zhang
    • Rong‑Jiang Li
  • View Affiliations

  • Published online on: May 27, 2014     https://doi.org/10.3892/mmr.2014.2275
  • Pages: 887-890
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Abstract

Obesity increases the incidence, progression and mortality of breast cancer among postmenopausal females. This is partly due to excessive estrogen production in the adipose tissue of obese females. Aromatase is a key enzyme in estrogen biosynthesis. In the current study, the tensional force‑triggered inducibility of aromatase expression was observed to vary in ASCs isolated from different disease‑free individuals. In addition, this phenomenon was associated with the activation of the aromatase PII promoter and its DNA methylation load. These findings highlight the impact of tensional forces on estrogen biosynthesis in obese females.
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August-2014
Volume 10 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zeng XC, Ao X, Yang HF, Zhang GX, Li WH, Liu QL, Tang YL, Xie YC, He WG, Huang YN, Huang YN, et al: Differential expression of stromal aromatase in obese females is regulated by DNA methylation. Mol Med Rep 10: 887-890, 2014
APA
Zeng, X., Ao, X., Yang, H., Zhang, G., Li, W., Liu, Q. ... Li, R. (2014). Differential expression of stromal aromatase in obese females is regulated by DNA methylation. Molecular Medicine Reports, 10, 887-890. https://doi.org/10.3892/mmr.2014.2275
MLA
Zeng, X., Ao, X., Yang, H., Zhang, G., Li, W., Liu, Q., Tang, Y., Xie, Y., He, W., Huang, Y., Zhang, L., Li, R."Differential expression of stromal aromatase in obese females is regulated by DNA methylation". Molecular Medicine Reports 10.2 (2014): 887-890.
Chicago
Zeng, X., Ao, X., Yang, H., Zhang, G., Li, W., Liu, Q., Tang, Y., Xie, Y., He, W., Huang, Y., Zhang, L., Li, R."Differential expression of stromal aromatase in obese females is regulated by DNA methylation". Molecular Medicine Reports 10, no. 2 (2014): 887-890. https://doi.org/10.3892/mmr.2014.2275