A germline mutation in the miR‑125a coding region reduces miR‑125a expression and is associated with human gastric cancer

Shang,Hua; Wang,Tao; Shang,Feng; Huang,Kun‑Ming; Li,Yan‑Qing

doi:10.3892/mmr.2014.2441

A germline mutation in the miR‑125a coding region reduces miR‑125a expression and is associated with human gastric cancer

Authors:
- Hua Shang
- Tao Wang
- Feng Shang
- Kun‑Ming Huang
- Yan‑Qing Li
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Affiliations: Department of Gastroenterology, Qilu Hospital of Shangdong University, Jinan, Shandong 250012, P.R. China, Department of Gastrointestinal Surgery, Linzi District People’s Hospital 255400, P.R. China, The 94th Hospital of Chinese People's Liberation Army, Nanchang, Jiangxi 330002, P.R. China, Department of Gastroenterology, General Hospital of Zibo, Zibo, Shandong 255036, P.R. China
Published online on: August 4, 2014 https://doi.org/10.3892/mmr.2014.2441
Pages: 1839-1844

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Abstract

MicroRNAs (miRNAs) are small non‑coding RNAs that inhibit the expression of target protein-coding genes, most often at the post‑transcriptional level. miRNAs are often found to be misregulated in human cancer and they can act as potent oncogenes or tumor suppressor genes. In this study, we found that a germline mutation in the miR‑125a coding region is associated with human gastric cancer. This mutation reduced the expression of mature miR‑125a and alleviated its inhibitory effect on erythroblastic leukemia viral oncogene homolog 2 (ERBB2) gene expression and on gastric tumor cell proliferation. Thus, the data of this study suggested that this germline mutation in pri‑miR‑125a likely contributes to the genetic predisposition to gastric cancer by reducing the production of miR‑125a, thereby interfering with the expression of miR‑125a target genes.

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