search button

Lycopene attenuates inflammation and apoptosis in post‑myocardial infarction remodeling by inhibiting the nuclear factor‑κB signaling pathway

  • Authors:
    • Qin He
    • Wei Zhou
    • Caijin Xiong
    • Gang Tan
    • Manhua Chen

  • View Affiliations

  • Published online on: October 16, 2014     https://doi.org/10.3892/mmr.2014.2676
  • Pages: 374-378
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Inflammatory response and cardiomyocyte apoptosis are important processes in ventricular remodeling post‑myocardial infarction (MI) and may form the basic mechanisms in the development of chronic heart failure. The nuclear factor κB (NF‑κB) signaling pathway could promote inflammation and apoptosis and it has been demonstrated that lycopene inhibits cigarette smoke extract‑mediated NF‑κB activation. Therefore, it was hypothesized that the NF‑κB signaling pathway may be a key target of lycopene in the reversal of ventricular remodeling post MI. An MI model was established by left anterior descending coronary artery ligation in mice. Following ligation, the mice were administered with lycopene (10 mg/kg/day) or saline. The mice underwent echocardiography and were sacrificed after 4 weeks. The mRNA expression of fibrosis markers transforming growth factor‑β1 (TGF‑β1), collagen I and III and inflammatory markers tumor necrosis factor‑α (TNF‑α) and interleukin‑1β (IL‑1β) were examined by quantitative polymerase chain reaction. The protein expression of apoptotic markers, including caspase‑3, ‑8, ‑9 and activation of the NF‑κB signaling pathway were analyzed by western blotting. Lycopene reduced the expression of TGF‑β1, collagen I, collagen III, TNF‑α, IL‑1β, caspase‑3, ‑8 and ‑9 and inhibited the activation of the NF‑κB signaling pathway. The level of ventricular remodeling post‑MI was also attenuated following treatment with lycopene. Lycopene may inhibit the NF‑κB signaling pathway thereby reducing the inflammatory response and cardiomyocyte apoptosis post‑MI, which could be a key mechanism of lycopene in attenuating ventricular remodeling.
View Figures
View References

Related Articles

Journal Cover

January-2015
Volume 11 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 7.6
  • CiteScore Rank: Q1: #82/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.647
  • SCImago Journal Rank (SJR): 0.781
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
He Q, Zhou W, Xiong C, Tan G and Chen M: Lycopene attenuates inflammation and apoptosis in post‑myocardial infarction remodeling by inhibiting the nuclear factor‑κB signaling pathway. Mol Med Rep 11: 374-378, 2015.
APA
He, Q., Zhou, W., Xiong, C., Tan, G., & Chen, M. (2015). Lycopene attenuates inflammation and apoptosis in post‑myocardial infarction remodeling by inhibiting the nuclear factor‑κB signaling pathway. Molecular Medicine Reports, 11, 374-378. https://doi.org/10.3892/mmr.2014.2676
MLA
He, Q., Zhou, W., Xiong, C., Tan, G., Chen, M."Lycopene attenuates inflammation and apoptosis in post‑myocardial infarction remodeling by inhibiting the nuclear factor‑κB signaling pathway". Molecular Medicine Reports 11.1 (2015): 374-378.
Chicago
He, Q., Zhou, W., Xiong, C., Tan, G., Chen, M."Lycopene attenuates inflammation and apoptosis in post‑myocardial infarction remodeling by inhibiting the nuclear factor‑κB signaling pathway". Molecular Medicine Reports 11, no. 1 (2015): 374-378. https://doi.org/10.3892/mmr.2014.2676