Pterostilbene attenuates the inflammatory reaction induced by ischemia/reperfusion in rat heart

  • Authors:
    • Min Lv
    • Kexiang Liu
    • Shaopeng Fu
    • Zhe Li
    • Xia Yu
  • View Affiliations

  • Published online on: October 21, 2014     https://doi.org/10.3892/mmr.2014.2719
  • Pages: 724-728
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Abstract

The role of pterostilbene (Pte) in inflammation induced by ischemia/reperfusion is not well understood. The aim of this study was to investigate whether Pte modulates neutrophil accumulation and the induction of tumor necrosis factor-α (TNF‑α) in an ischemia/reperfusion (I/R)‑injured rat heart model. Rats were randomly exposed to a sham operation, myocardial ischemia/reperfusion (MI/R) alone, MI/R+Pte, MI/R+Pte+L‑NAME and MI/R+Pte+ (methylene blue) MB. The results demonstrated that compared with MI/R, Pte reduced the area of myocardial infarction, the levels of myocardial myeloperoxidase, serum creatinine kinase and lactate dehydrogenase, and the production of serum and myocardial TNF‑α. These Pte‑induced effects were eliminated by the administration of L‑NAME, a nitric oxide (NO) synthase inhibitor, and MB, a cyclic guanosine monophosphate (cGMP) inhibitor. In conclusion, Pte produces cardioprotective and anti‑inflammatory effects. These effects may be associated with an increase in NO production, the inhibition of neutrophil accumulation, and induction of TNF‑α and cGMP signaling pathways in myocardium subjected to MI/R.
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January-2015
Volume 11 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Lv M, Liu K, Fu S, Li Z and Yu X: Pterostilbene attenuates the inflammatory reaction induced by ischemia/reperfusion in rat heart. Mol Med Rep 11: 724-728, 2015.
APA
Lv, M., Liu, K., Fu, S., Li, Z., & Yu, X. (2015). Pterostilbene attenuates the inflammatory reaction induced by ischemia/reperfusion in rat heart. Molecular Medicine Reports, 11, 724-728. https://doi.org/10.3892/mmr.2014.2719
MLA
Lv, M., Liu, K., Fu, S., Li, Z., Yu, X."Pterostilbene attenuates the inflammatory reaction induced by ischemia/reperfusion in rat heart". Molecular Medicine Reports 11.1 (2015): 724-728.
Chicago
Lv, M., Liu, K., Fu, S., Li, Z., Yu, X."Pterostilbene attenuates the inflammatory reaction induced by ischemia/reperfusion in rat heart". Molecular Medicine Reports 11, no. 1 (2015): 724-728. https://doi.org/10.3892/mmr.2014.2719