Open Access

Comparison of biological properties of umbilical cord‑derived mesenchymal stem cells from early and late passages: Immunomodulatory ability is enhanced in aged cells

  • Authors:
    • Yong Zhuang
    • Dong Li
    • Jinqiu Fu
    • Qing Shi
    • Yuanyuan Lu
    • Xiuli Ju
  • View Affiliations

  • Published online on: October 23, 2014     https://doi.org/10.3892/mmr.2014.2755
  • Pages: 166-174
  • Copyright: © Zhuang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mesenchymal stem cells (MSCs) are a potential source of adult stem cells for cell‑based therapeutics due to their substantial multilineage differentiation capacity and secretory functions. No information is presently available regarding the maintenance of immunosuppressive properties of this cell type with repeated passages. It was therefore the aim of the present study to analyze the biological properties, particularly the immunoregulatory effect, of MSCs from late passages. The differences between young and old MSCs in morphology, cell surface antigen phenotype, proliferation, gene expression and immunomodulatory ability were investigated. The results of the current study demonstrated that with the passage of cells, senescent MSCs displayed a characteristically enlarged and flattened morphology, different gene expression profiles and stronger immunosuppressive activities. Increased interleukin‑6 production may be a possible underlying mechanism for this enhanced immunomodulatory ability of MSCs. These findings suggest that aged MSCs may provide a treatment option for patients with graft versus host disease and other diseases associated with dysregulation of the immune system.
View Figures
View References

Related Articles

Journal Cover

January-2015
Volume 11 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhuang Y, Li D, Fu J, Shi Q, Lu Y and Ju X: Comparison of biological properties of umbilical cord‑derived mesenchymal stem cells from early and late passages: Immunomodulatory ability is enhanced in aged cells. Mol Med Rep 11: 166-174, 2015.
APA
Zhuang, Y., Li, D., Fu, J., Shi, Q., Lu, Y., & Ju, X. (2015). Comparison of biological properties of umbilical cord‑derived mesenchymal stem cells from early and late passages: Immunomodulatory ability is enhanced in aged cells. Molecular Medicine Reports, 11, 166-174. https://doi.org/10.3892/mmr.2014.2755
MLA
Zhuang, Y., Li, D., Fu, J., Shi, Q., Lu, Y., Ju, X."Comparison of biological properties of umbilical cord‑derived mesenchymal stem cells from early and late passages: Immunomodulatory ability is enhanced in aged cells". Molecular Medicine Reports 11.1 (2015): 166-174.
Chicago
Zhuang, Y., Li, D., Fu, J., Shi, Q., Lu, Y., Ju, X."Comparison of biological properties of umbilical cord‑derived mesenchymal stem cells from early and late passages: Immunomodulatory ability is enhanced in aged cells". Molecular Medicine Reports 11, no. 1 (2015): 166-174. https://doi.org/10.3892/mmr.2014.2755