Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer

  • Authors:
    • Yi Zhu
    • Jian Wu
    • Shiqi Li
    • Xiao Wang
    • Zhen Liang
    • Xianglai Xu
    • Xin Xu
    • Zhenghui Hu
    • Yiwei Lin
    • Hong Chen
    • Jie Qin
    • Qiqi Mao
    • Liping Xie
  • View Affiliations

  • Published online on: October 29, 2014     https://doi.org/10.3892/mmr.2014.2801
  • Pages: 1004-1008
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Abstract

The mortality rate associated with prostate cancer is mainly due to metastases rather than primary organ‑confined disease. Decreasing the incidence of metastasis is important in treating prostate cancer. 4',5,7‑trihydroxyflavone (apigenin) has been demonstrated to be effective in inhibiting several types of cancer. The aim of this study was to investigate the effect and mechanism of apigenin on the movement of prostate cancer cells. In the present study, DU145 cells were treated with varying concentrations of apigenin for different time periods. Cell viability was evaluated using an MTT assay. Cell motility and invasiveness were assayed using wound healing assays and a Matrigel migration and invasion assay. Flow cytometric and western blot analyses were performed to examine the cell cycle and signaling pathways. The results demonstrated that apigenin suppressed the proliferation and inhibited the migration and invasive potential of the DU145 prostate cancer cells in a dose‑ and time‑dependent manner, which was associated with epithelial mesenchymal transition. These findings suggested that apigenin may be effective in treating human prostate cancer.
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February-2015
Volume 11 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhu Y, Wu J, Li S, Wang X, Liang Z, Xu X, Xu X, Hu Z, Lin Y, Chen H, Chen H, et al: Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer. Mol Med Rep 11: 1004-1008, 2015.
APA
Zhu, Y., Wu, J., Li, S., Wang, X., Liang, Z., Xu, X. ... Xie, L. (2015). Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer. Molecular Medicine Reports, 11, 1004-1008. https://doi.org/10.3892/mmr.2014.2801
MLA
Zhu, Y., Wu, J., Li, S., Wang, X., Liang, Z., Xu, X., Xu, X., Hu, Z., Lin, Y., Chen, H., Qin, J., Mao, Q., Xie, L."Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer". Molecular Medicine Reports 11.2 (2015): 1004-1008.
Chicago
Zhu, Y., Wu, J., Li, S., Wang, X., Liang, Z., Xu, X., Xu, X., Hu, Z., Lin, Y., Chen, H., Qin, J., Mao, Q., Xie, L."Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer". Molecular Medicine Reports 11, no. 2 (2015): 1004-1008. https://doi.org/10.3892/mmr.2014.2801