Intercellular adhesion molecule‑1 expression in activated eosinophils is associated with mucosal remodeling in nasal polyps

Xin,Jingwei; Sun,Hui; Kong,Hong; Li,Lin; Zheng,Jun; Yin,Chunxia; Cao,Yang; Jia,Yunxiao; Li,Chaoxu

doi:10.3892/mmr.2015.3174

Intercellular adhesion molecule‑1 expression in activated eosinophils is associated with mucosal remodeling in nasal polyps

Authors:
- Jingwei Xin
- Hui Sun
- Hong Kong
- Lin Li
- Jun Zheng
- Chunxia Yin
- Yang Cao
- Yunxiao Jia
- Chaoxu Li
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Affiliations: Department of Otorhinolaryngology‑Head and Neck Surgery, China‑Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China, Department of Thyroid Surgery, Jilin Provincial Key Laboratory of Surgical Translational Medicine, China‑Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China, Department of Gynecology and Obstertrics, Changchun Obstetrics‑Gynecology Hospital, Changchun, Jilin 130042, P.R. China, Department of Cerebral Surgery, The People's Hospital of Changchun, Changchun, Jilin 130051, P.R. China
Published online on: January 9, 2015 https://doi.org/10.3892/mmr.2015.3174
Pages: 3391-3397
Copyright: © Xin et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Nasal polyposis (NP) is characterized by chronic mucosal inflammation with infiltrating eosinophils. Eosinophil‑mediated tissue remodeling may be involved in NP pathogenesis; therefore, improved understanding of tissue remodeling may result the identification of novel pathways and therapeutic strategies. The present study aimed to investigate the pathological changes occurring during tissue remodeling in NP, in order to assess the role of intercellular adhesion molecule‑1 (ICAM‑1) in localized tissue remodeling and the potential association between ICAM‑1 expression and markers of eosinophil activation. A total of 28 eligible patients and 10 healthy controls participated in the current study. Nasal mucosal tissues of these subjects were retrospectively evaluated for mucosal remodeling using histopathological staining. ICAM‑1 and eosinophil cationic protein (ECP) expression levels were determined by immunohistochemical analysis. Compared with the healthy controls, all the specimens from NP patients presented substantial epithelial damage, skewed cellular distribution with a reduced density of goblet cells, an increased density of subepithelial gland and increased subepithelial collagen deposition. In addition, the NP specimens exhibited significantly higher eosinophil infiltration and ICAM‑1 expression compared with the controls. Positive correlations were observed between ICAM‑1 and ECP expression levels (P=0.010), as well as between extracellular collagen deposition and ICAM‑1 (P=0.010) and ECP (P=0.012) expression levels in the NP specimens, but not in the control specimens. Morphological evidence demonstrated eosinophil‑mediated tissue remodeling in NP tissues. ICAM‑1 expression in activated eosinophils was associated with NP remodeling, indicating the possibility that ICAM‑1 may regulate NP remodeling.

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