Open Access

Fibroblast activation protein α in tumor microenvironment: Recent progression and implications (Review)

  • Authors:
    • Fuming Zi
    • Jingsong He
    • Donghua He
    • Yi Li
    • Li Yang
    • Zhen Cai
  • View Affiliations

  • Published online on: January 14, 2015     https://doi.org/10.3892/mmr.2015.3197
  • Pages: 3203-3211
  • Copyright: © Zi et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Accumulated evidence has demonstrated that the microenvironment of a given tumor is important in determining its drug resistance, tumorigenesis, progression and metastasis. These microenvironments, like tumor cells, are vital targets for cancer therapy. The cross-talk between tumor cells and cancer-associated fibroblasts (CAFs, alternatively termed activated fibroblasts) is crucial in regulating the drug resistance, tumorigenesis, neoplastic progression, angiogenesis, invasion and metastasis of a tumor. Fibroblast activation protein α (FAPα) is a transmembrane serine protease and is highly expressed on CAFs present in >90% of human epithelial neoplasms. FAPα activity, alongside that of gelatinase and type I collagenase, has become increasingly important in cancer therapy due to its effectiveness in modulating tumor behavior. In this review, recent progression in the knowledge of the role of FAPα in tumor microenvironments is discussed.
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May-2015
Volume 11 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zi F, He J, He D, Li Y, Yang L and Cai Z: Fibroblast activation protein α in tumor microenvironment: Recent progression and implications (Review). Mol Med Rep 11: 3203-3211, 2015.
APA
Zi, F., He, J., He, D., Li, Y., Yang, L., & Cai, Z. (2015). Fibroblast activation protein α in tumor microenvironment: Recent progression and implications (Review). Molecular Medicine Reports, 11, 3203-3211. https://doi.org/10.3892/mmr.2015.3197
MLA
Zi, F., He, J., He, D., Li, Y., Yang, L., Cai, Z."Fibroblast activation protein α in tumor microenvironment: Recent progression and implications (Review)". Molecular Medicine Reports 11.5 (2015): 3203-3211.
Chicago
Zi, F., He, J., He, D., Li, Y., Yang, L., Cai, Z."Fibroblast activation protein α in tumor microenvironment: Recent progression and implications (Review)". Molecular Medicine Reports 11, no. 5 (2015): 3203-3211. https://doi.org/10.3892/mmr.2015.3197