Open Access

Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo

Corrigendum in: /10.3892/mmr.2018.8571

  • Authors:
    • Wenhua Zhan
    • Xingbin Hu
    • Jing Yi
    • Qunxing An
    • Xiaofeng Huang
  • View Affiliations

  • Published online on: February 10, 2015     https://doi.org/10.3892/mmr.2015.3326
  • Pages: 4142-4148
  • Copyright: © Zhan et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Apogossypol, a gossypol derivative, is a novel small‑molecule inhibitor of the Bcl‑2 family proteins and has been demonstrated to have anti‑tumor activities. Prostate cancer is the most common malignancy in males, for which chemotherapy is the usual treatment option in clinical practice. The aim of the present study was to investigate the growth inhibitory effects of apogossypol on prostate cancers in vitro and in vivo. An MTT assay and a colony formation assay were used to assess the anti‑survival and anti‑proliferation effects of apogossypol in LNCaP cells. Immunofluorescence was performed in order to detect the expression levels of apoptosis‑associated proteins in xenograft tumors following apogossypol treatment. Apogossypol exerted strong anti‑tumor effects on LNCaP cells in a dose‑dependent manner. Furthermore, immunofluorescence revealed that apogossypol inhibited the growth and proliferation of prostate cancer cells by downregulating Bcl‑2 protein expression and activating caspase‑3 and ‑8. In addition, the in vivo study indicated that apogossypol significantly inhibited tumor growth in a dose‑dependent manner with reduced toxicity compared with gossypol. In conclusion, the present study indicated that apogossypol effectively inhibited the growth and proliferation of prostate cancer cells and may be a potential agent for prostate cancer therapy.
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June-2015
Volume 11 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhan W, Hu X, Yi J, An Q and Huang X: Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo Corrigendum in /10.3892/mmr.2018.8571. Mol Med Rep 11: 4142-4148, 2015.
APA
Zhan, W., Hu, X., Yi, J., An, Q., & Huang, X. (2015). Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo Corrigendum in /10.3892/mmr.2018.8571. Molecular Medicine Reports, 11, 4142-4148. https://doi.org/10.3892/mmr.2015.3326
MLA
Zhan, W., Hu, X., Yi, J., An, Q., Huang, X."Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo Corrigendum in /10.3892/mmr.2018.8571". Molecular Medicine Reports 11.6 (2015): 4142-4148.
Chicago
Zhan, W., Hu, X., Yi, J., An, Q., Huang, X."Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo Corrigendum in /10.3892/mmr.2018.8571". Molecular Medicine Reports 11, no. 6 (2015): 4142-4148. https://doi.org/10.3892/mmr.2015.3326