search button

Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome

  • Authors:
    • Yamei Du
    • Guojun Zhang
    • Zaiqiang Zhang
    • Qian Wang
    • Ruimin Ma
    • Limin Zhang
    • Fei Fan
    • Youran Li
    • Meng Wang
    • Hong Lv
    • Xixiong Kang

  • View Affiliations

  • Published online on: May 5, 2015     https://doi.org/10.3892/mmr.2015.3730
  • Pages: 3207-3213
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Guillain-Barré syndrome (GBS) is an autoimmune disorder of the peripheral nervous system characterized by weakness in the limbs. To date, numerous hypotheses have been suggested to explain the pathogenesis of GBS; however, the pathogenesis of GBS remains to be elucidated. The aim of the present study was to investigate the association between Toll‑like receptor (TLR) 2, TLR4 and GBS. Therefore, the mRNA of TLR2, TLR4, myeloid differentiation factor (MyD)88 and nuclear factor (NF)‑κB of peripheral blood mononuclear cells (PBMCs) in patients with GBS and healthy controls was assessed. To confirm the function of TLR2 and TLR4 in the pathogenesis of GBS, PBMCs derived from patients with GBS and healthy controls were cultured with various TLR agonists. The levels of tumor necrosis factor (TNF)‑α and interleukin (IL)‑1β were measured in the culture supernatant and fasting serum was obtained for the detection of anti‑ganglioside antibodies. The results revealed that the mRNA levels of TLR2, TLR4, MyD88 and NF‑κB were significantly increased in patients with GBS compared with those in healthy controls (P=0.003, 0.017, 0.032 and 0.015, respectively). PBMCs from patients with GBS secreted higher levels of TNF‑α and IL‑1β than those from control subjects. The positive rate of immunoglobulin (Ig)G and IgM anti‑ganglioside antibodies in patients with severe GBS was 42.86%, which was markedly higher than rates found in patients with mild GBS (9.09 and 18.18%, respectively). The results of the present study demonstrated that TLR2 and TLR4 are involved in the pathogenesis of GBS and that they and their associated signaling pathways may be targets for the treatment of GBS.
View Figures
View References

Related Articles

Journal Cover

August-2015
Volume 12 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 7.6
  • CiteScore Rank: Q1: #82/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.647
  • SCImago Journal Rank (SJR): 0.781
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Du Y, Zhang G, Zhang Z, Wang Q, Ma R, Zhang L, Fan F, Li Y, Wang M, Lv H, Lv H, et al: Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome. Mol Med Rep 12: 3207-3213, 2015.
APA
Du, Y., Zhang, G., Zhang, Z., Wang, Q., Ma, R., Zhang, L. ... Kang, X. (2015). Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome. Molecular Medicine Reports, 12, 3207-3213. https://doi.org/10.3892/mmr.2015.3730
MLA
Du, Y., Zhang, G., Zhang, Z., Wang, Q., Ma, R., Zhang, L., Fan, F., Li, Y., Wang, M., Lv, H., Kang, X."Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome". Molecular Medicine Reports 12.2 (2015): 3207-3213.
Chicago
Du, Y., Zhang, G., Zhang, Z., Wang, Q., Ma, R., Zhang, L., Fan, F., Li, Y., Wang, M., Lv, H., Kang, X."Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome". Molecular Medicine Reports 12, no. 2 (2015): 3207-3213. https://doi.org/10.3892/mmr.2015.3730