Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice

  • Authors:
    • Tao Wang
    • Ji‑Na Lim
    • Jae‑Sung Lee
    • Sang‑Bum Lee
    • Jin‑Hee Hwang
    • U‑Suk Jung
    • Min‑Jeong Kim
    • Dae‑Youn Hwang
    • Sang‑Rak Lee
    • Sang‑Gun Roh
    • Hong‑Gu Lee
  • View Affiliations

  • Published online on: May 8, 2015     https://doi.org/10.3892/mmr.2015.3767
  • Pages: 3200-3206
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to investigate the effects of dietary trans fatty acids in mice. Following the administration of a 0.5/100 g diet of trans‑9 octadecenoic acid (EA), trans‑11 vaccenic acid (TVA) or cis‑9, trans‑11 conjugated linoleic acid (CLA) for 4 weeks, the body weights and the weights of the liver, testis and mediastinal adipose tissue (MAT) of the animals gradually decreased (P<0.05). The EA group exhibited the lowest levels of magnesium and triglycerides (P<0.05). CLA increased villus length (P<0.05), while EA and TVA decreased villus length (P<0.05). The TVA group exhibited the lowest levels of low‑density lipoprotein and tumor necrosis factor‑α (P<0.05). Taken together, EA, TVA and CLA affected the physiological conditions of mice differently. The potential effects of three well-known fatty acids, including trans‑9 octadecenoic acid (EA), trans‑11 vaccenic acid (TVA) and cis‑9, trans‑11 conjugated linoleic acid (CLA), in animals or humans remain to be elucidated. Therefore, in the present study, 32 animals were randomly divided into four groups and administered a 0.5/100 g diet of EA, TVA or CLA for 4 weeks. The results demonstrated that the body weights and the weights of the liver, testis and mediastinal adipose tissue (MAT) of the animals gradually decreased (P<0.05). Blood was collected individually via the external jugular veins and the EA group exhibited the lowest levels of magnesium and triglycerides (P<0.05). CLA increased villus length (P<0.05), while EA and TVA decreased villus length (P<0.05). The TVA group exhibited the lowest levels of low‑density lipoprotein and tumor necrosis factor‑α (P<0.05). Taken together, EA, TVA and CLA affected the physiological conditions of mice differently and these may further our understanding of the various effects of these fatty acids on animals and humans.
View Figures
View References

Related Articles

Journal Cover

August-2015
Volume 12 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang T, Lim JN, Lee JS, Lee SB, Hwang JH, Jung US, Kim MJ, Hwang DY, Lee SR, Roh SG, Roh SG, et al: Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice. Mol Med Rep 12: 3200-3206, 2015.
APA
Wang, T., Lim, J., Lee, J., Lee, S., Hwang, J., Jung, U. ... Lee, H. (2015). Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice. Molecular Medicine Reports, 12, 3200-3206. https://doi.org/10.3892/mmr.2015.3767
MLA
Wang, T., Lim, J., Lee, J., Lee, S., Hwang, J., Jung, U., Kim, M., Hwang, D., Lee, S., Roh, S., Lee, H."Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice". Molecular Medicine Reports 12.2 (2015): 3200-3206.
Chicago
Wang, T., Lim, J., Lee, J., Lee, S., Hwang, J., Jung, U., Kim, M., Hwang, D., Lee, S., Roh, S., Lee, H."Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice". Molecular Medicine Reports 12, no. 2 (2015): 3200-3206. https://doi.org/10.3892/mmr.2015.3767