MicroRNA-338-3p suppresses tumor growth of esophageal squamous cell carcinoma in vitro and in vivo Retraction in /10.3892/mmr.2021.12450

Li,Xinyu; Li,Zhihong; Yang,Guiyun; Pan,Zhenxiang

doi:10.3892/mmr.2015.3820

MicroRNA-338-3p suppresses tumor growth of esophageal squamous cell carcinoma in vitro and in vivo

Retraction in: /10.3892/mmr.2021.12450

Authors:
- Xinyu Li
- Zhihong Li
- Guiyun Yang
- Zhenxiang Pan
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Affiliations: Department of Anesthesiology, The Second Hospital, Jilin University, Changchun, Jilin 130041, P.R. China, Department of Thoracic Surgery, The First Hospital, Jilin University, Changchun, Jilin 130021, P.R. China
Published online on: May 22, 2015 https://doi.org/10.3892/mmr.2015.3820
Pages: 3951-3957

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Abstract

Accumulating evidence has shown that microRNAs (miRNAs) are aberrantly expressed in human esophageal squamous cell carcinoma (ESCC) and are crucial in tumorigenesis, among which miR‑338‑3p has been examined to be downregulated in patients with ESCC. However, the role of miR‑338‑3p in ESCC remains to be elucidated. In the present study, the role of miR‑338‑3p on the growth and survival of an ESCC cell line was determined with several in vitro approaches and in nude mouse models. It was determined that miR‑338‑3p expression was frequently downregulated in ESCC tissue compared with corresponding adjacent non‑tumor tissue, and that its expression was significantly correlated with tumor stage and metastasis. Overexpression of miR‑338‑3p in ESCC cells suppressed cell proliferation, colony formation, migration and invasion, and induced cell arrest at the G0/G1 stage and cell apoptosis in vitro. In addition, it was demonstrated that overexpression of miR‑338‑3p significantly suppresses tumor growth of xenograft tumors in mice (P<0.05). These findings revealed that miR‑338‑3p may act as a tumor suppressor in ESCC, and its dysregulation may be involved in the initiation and development of human ESCC. In addition, it was suggested that miR‑338‑3p may be a potential therapeutic agent for treatment of ESCC.

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