Increased expression of Notch 1 in a rat liver transplantation model

  • Authors:
    • Lihong Chen
    • Wubing He
    • Kaida Huang
    • Lin Zheng
    • Lingyun Gao
    • Jingfeng Liu
    • Aimin Huang
  • View Affiliations

  • Published online on: July 2, 2015     https://doi.org/10.3892/mmr.2015.4026
  • Pages: 5293-5297
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Abstract

Liver transplantation is the standard treatment for end‑stage liver failure; however, rejection can result in allograft failure. In order to investigate the role of Notch 1 during rejection, the present study evaluated Notch 1 expression, as well as the levels of immune reactivity, in rat liver allografts. A heterotopic liver transplantation model was established using Dark Agouti (DA) rats as donors and Lewis rats as recipients (DA/Lewis), with DA recipient rats serving as controls (DA/DA). The concentration levels of immune reactivity markers and serum Notch 1 were measured on days 3, 5, and 7. The overall survival was significantly shorter (<10 days) in the DA/Lewis group, as compared with the DA/DA group (P<0.0001). The concentration levels of serum alanine aminotransferase and total bilirubin were significantly higher 5 and 7 days following transplantation in the DA/Lewis group, as compared with the DA/DA group (P<0.001). The concentration levels of serum Notch 1 were significantly higher in the DA/Lewis group, as compared with the DA/DA group on days 3, 5, and 7 following transplantation (P<0.0001). These results indicate that the expression levels of serum Notch 1 significantly increase during liver allograft rejection, suggesting that Notch 1 is involved in the mechanism underlying liver allograft rejection. Notch 1 may serve as a marker of acute rejection in a rat liver transplantation model.
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October-2015
Volume 12 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Chen L, He W, Huang K, Zheng L, Gao L, Liu J and Huang A: Increased expression of Notch 1 in a rat liver transplantation model. Mol Med Rep 12: 5293-5297, 2015.
APA
Chen, L., He, W., Huang, K., Zheng, L., Gao, L., Liu, J., & Huang, A. (2015). Increased expression of Notch 1 in a rat liver transplantation model. Molecular Medicine Reports, 12, 5293-5297. https://doi.org/10.3892/mmr.2015.4026
MLA
Chen, L., He, W., Huang, K., Zheng, L., Gao, L., Liu, J., Huang, A."Increased expression of Notch 1 in a rat liver transplantation model". Molecular Medicine Reports 12.4 (2015): 5293-5297.
Chicago
Chen, L., He, W., Huang, K., Zheng, L., Gao, L., Liu, J., Huang, A."Increased expression of Notch 1 in a rat liver transplantation model". Molecular Medicine Reports 12, no. 4 (2015): 5293-5297. https://doi.org/10.3892/mmr.2015.4026