Activation of Toll-like receptor 7 inhibits the proliferation and migration, and induces the apoptosis of pancreatic cancer cells

  • Authors:
    • Bing‑Bing Zou
    • Fang Wang
    • Lei Li
    • Feng‑Wei Cheng
    • Rui Jin
    • Xin Luo
    • Li‑Xin Zhu
    • Xiaoping Geng
    • Sheng‑Quan Zhang
  • View Affiliations

  • Published online on: July 28, 2015     https://doi.org/10.3892/mmr.2015.4130
  • Pages: 6079-6085
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Abstract

Pancreatic cancer is one of the most malignant types of tumor and has a poor prognosis. Toll‑like receptor 7 (TLR7) has been found to be present and have different roles in different types of cancer cells. In the present study, the roles of TLR7 in BxPC‑3 cells, a human pancreatic adenocarcinoma cell line, were investigated. The cells were treated with gardiquimod, an agonist of TLR7, following which the properties of the cells, including proliferation, migration, cell cycle and apoptosis, were analyzed. It was revealed that activation of TLR7 by gardiquimod inhibited cell proliferation and migration, and induced apoptosis of the cells. In addition, gardiquimod downregulated the expression levels of cyclin B1, cyclin E and B‑cell lymphoma 2, while upregulating the expression of B‑cell‑associated X protein. These results suggested that the activation of TLR7 suppresses the progression of pancreatic cancer.
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October-2015
Volume 12 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zou BB, Wang F, Li L, Cheng FW, Jin R, Luo X, Zhu LX, Geng X and Zhang SQ: Activation of Toll-like receptor 7 inhibits the proliferation and migration, and induces the apoptosis of pancreatic cancer cells. Mol Med Rep 12: 6079-6085, 2015.
APA
Zou, B., Wang, F., Li, L., Cheng, F., Jin, R., Luo, X. ... Zhang, S. (2015). Activation of Toll-like receptor 7 inhibits the proliferation and migration, and induces the apoptosis of pancreatic cancer cells. Molecular Medicine Reports, 12, 6079-6085. https://doi.org/10.3892/mmr.2015.4130
MLA
Zou, B., Wang, F., Li, L., Cheng, F., Jin, R., Luo, X., Zhu, L., Geng, X., Zhang, S."Activation of Toll-like receptor 7 inhibits the proliferation and migration, and induces the apoptosis of pancreatic cancer cells". Molecular Medicine Reports 12.4 (2015): 6079-6085.
Chicago
Zou, B., Wang, F., Li, L., Cheng, F., Jin, R., Luo, X., Zhu, L., Geng, X., Zhang, S."Activation of Toll-like receptor 7 inhibits the proliferation and migration, and induces the apoptosis of pancreatic cancer cells". Molecular Medicine Reports 12, no. 4 (2015): 6079-6085. https://doi.org/10.3892/mmr.2015.4130