Catabolite control protein A has an important role in the metabolic regulation of Streptococcus suis type 2 according to iTRAQ-based quantitative proteomic analysis

Lang,Xulong; Wan,Zhonghai; Pan,Ying; Bu,Zhaoyang; Wang,Xiuran; Wang,Xiaoxu; Ji,Xue; Zhu,Lingwei; Wan,Jiayu; Sun,Yang; Wang,Xinglong

doi:10.3892/mmr.2015.4211

Catabolite control protein A has an important role in the metabolic regulation of Streptococcus suis type 2 according to iTRAQ-based quantitative proteomic analysis

Authors:
- Xulong Lang
- Zhonghai Wan
- Ying Pan
- Zhaoyang Bu
- Xiuran Wang
- Xiaoxu Wang
- Xue Ji
- Lingwei Zhu
- Jiayu Wan
- Yang Sun
- Xinglong Wang
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Affiliations: Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China, Department of Orthodontics, Changchun Stomatological Hospital, Changchun, Jilin 130042, P.R. China, School of Life Science, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China
Published online on: August 11, 2015 https://doi.org/10.3892/mmr.2015.4211
Pages: 5967-5972

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Abstract

The catabolite control protein A (ccpA) regulates the carbon metabolism in Streptococcus suis type 2 and has pleiotropic regulatory functions in bacterial virulence and transcription. The present study systematically investigated ccpA activity in Streptococcus suis type 2 using isobaric tag for relative and absolute quantification (iTRAQ) liquid chromatography‑tandem mass spectrometry‑based proteomics. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses demonstrated that ccpA is an important protein for the regulation of metabolism, virulence and immune pathways in Streptococcus suis type 2. The present study therefore expanded the current understanding of the effects of ccpA on virulence, metabolic regulation and transcription in Streptococcus suis type 2 and other important pathogens.

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