IL‑33 and kidney disease (Review)

  • Authors:
    • Feifei Yang
    • Ping Zhu
    • Lihua Duan
    • Lin Yang
    • Jiajun Wang
  • View Affiliations

  • Published online on: November 6, 2015     https://doi.org/10.3892/mmr.2015.4516
  • Pages: 3-8
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Abstract

Interleukin (IL)‑33, is a novel member of the IL‑1 superfamily, and act as a dual‑function molecule as a nuclear factor and cytokine. The expression of IL‑33 can be detected in several tissues and cells in humans and in mice. In addition to the conventional secretion approach for cytokines, full‑length IL‑33 can also be released into the extracellular space following cell damage or mechanical injury. IL‑33 mediates its biological effects by interacting with the receptors, suppression of tumorigenicity 2 (ST2) and IL‑1 receptor accessory protein, activating intracellular molecules in the nuclear factor‑κB and mitogen‑activated protein kinase signaling pathways, which drive the production of type 2 cytokines, including IL‑4, IL‑5 and IL‑13, from polarized T helper 2 cells. Increasing evidence indicates that IL‑33 is important in chronic kidney disease, and may be involved in the progression of renal fibrosis associated with systemic lupus erythematosus and renal graft damage. In addition, IL‑33 contributes to acute kidney injury. In the present review, the biology of IL‑33, and the association of IL‑33 with kidney diseases are discussed.
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January-2016
Volume 13 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yang F, Zhu P, Duan L, Yang L and Wang J: IL‑33 and kidney disease (Review). Mol Med Rep 13: 3-8, 2016.
APA
Yang, F., Zhu, P., Duan, L., Yang, L., & Wang, J. (2016). IL‑33 and kidney disease (Review). Molecular Medicine Reports, 13, 3-8. https://doi.org/10.3892/mmr.2015.4516
MLA
Yang, F., Zhu, P., Duan, L., Yang, L., Wang, J."IL‑33 and kidney disease (Review)". Molecular Medicine Reports 13.1 (2016): 3-8.
Chicago
Yang, F., Zhu, P., Duan, L., Yang, L., Wang, J."IL‑33 and kidney disease (Review)". Molecular Medicine Reports 13, no. 1 (2016): 3-8. https://doi.org/10.3892/mmr.2015.4516