Activating transcription factor 3 ‑ an endogenous inhibitor of myocardial ischemia-reperfusion injury (Review)

  • Authors:
    • Chao‑Jun Yang
    • Jun Yang
    • Zhi‑Xing Fan
    • Jian Yang
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  • Published online on: November 6, 2015     https://doi.org/10.3892/mmr.2015.4529
  • Pages: 9-12
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Abstract

Coronary heart diseases, particularly acute coronary syndrome, have increased in morbidity and mortality in recent decades. Percutaneous coronary intervention, coronary artery bypass grafting and thrombolytic agents are effective strategies to rescue the infarcted myocardium. In addition to acute myocardial infarction, the resulting myocardial ischemia‑reperfusion injury (MIRI) leads to serious secondary injury of the heart. Studies have demonstrated that activating transcription factor (ATF)/cyclic adenosine monophosphate response element binding family member ATF3 had a negative regulatory role in IRI, particularly in the kidney, cerebrum and liver. The present review expounded the expression characteristics of ATF3 and its protective effects against MIRI, providing a theoretical basis for the overexpression of ATF3 in the myocardium as a promising gene-therapeutic strategy for MIRI.
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January-2016
Volume 13 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yang CJ, Yang J, Fan ZX and Yang J: Activating transcription factor 3 ‑ an endogenous inhibitor of myocardial ischemia-reperfusion injury (Review). Mol Med Rep 13: 9-12, 2016.
APA
Yang, C., Yang, J., Fan, Z., & Yang, J. (2016). Activating transcription factor 3 ‑ an endogenous inhibitor of myocardial ischemia-reperfusion injury (Review). Molecular Medicine Reports, 13, 9-12. https://doi.org/10.3892/mmr.2015.4529
MLA
Yang, C., Yang, J., Fan, Z., Yang, J."Activating transcription factor 3 ‑ an endogenous inhibitor of myocardial ischemia-reperfusion injury (Review)". Molecular Medicine Reports 13.1 (2016): 9-12.
Chicago
Yang, C., Yang, J., Fan, Z., Yang, J."Activating transcription factor 3 ‑ an endogenous inhibitor of myocardial ischemia-reperfusion injury (Review)". Molecular Medicine Reports 13, no. 1 (2016): 9-12. https://doi.org/10.3892/mmr.2015.4529