Isolation and comparison of mesenchymal stem cell‑like cells derived from human gastric cancer tissues and corresponding ovarian metastases

Zhou,Kunyan; Xia,Man; Tang,Bo; Yang,Darong; Liu,Nianli; Tang,Dihong; Xie,Hailong; Wang,Xiaohong; Zhu,Haizhen; Liu,Chen; Zuo,Chaohui

doi:10.3892/mmr.2015.4735

Isolation and comparison of mesenchymal stem cell‑like cells derived from human gastric cancer tissues and corresponding ovarian metastases

Authors:
- Kunyan Zhou
- Man Xia
- Bo Tang
- Darong Yang
- Nianli Liu
- Dihong Tang
- Hailong Xie
- Xiaohong Wang
- Haizhen Zhu
- Chen Liu
- Chaohui Zuo
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Affiliations: Department of Gastroduodenal and Pancreatic Surgery, Laboratory of Digestive Oncology, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, Hunan 410013, P.R. China, Department of Gynaecological Oncology, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, Hunan 410013, P.R. China, Department of Molecular Medicine, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan 410082, P.R. China, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, P.R. China, Department of Pathology, Immunology and Laboratory Medicine, Shands Cancer Center, University of Florida, Gainesville, FL 32610‑0275, USA
Published online on: December 30, 2015 https://doi.org/10.3892/mmr.2015.4735
Pages: 1788-1794

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Abstract

Mesenchymal stem cell (MSC)‑like cells have been isolated from various types of tumor. It has previously been reported that MSCs are involved in tumorigenesis and its prognosis. The aim of the present study was to isolate and compare MSC‑like cells from human gastric cancer (GC) and its metastatic deposits in ovarian tissue. MSC‑like cells were isolated from human gastric cancer (hGC‑MSCs) and the corresponding ovarian metastatic tissues (hGCOM‑MSCs) from 40 patients. The characteristics of hGC‑MSCs and hGCOM‑MSCs, including their morphology, surface antigens, specific gene expression and differentiation potential, were similar to those of MSCs derived from human bone marrow (hBM‑MSCs) but different from GC cells. In conclusion, the present study demonstrated that MSC‑like cells could be isolated from GC tissue and its ovarian metastatic tissues. The existence of MSC‑like cells in GC tissues and its ovarian metastatic tissues suggests that they may be a potential target for cancer therapy, and provides an experimental foundation for investigating their role in the initiation and progression of ovarian metastasis of GC.

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