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Article

Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho‑AKT in bladder cancer

  • Authors:
    • Shuai‑Shuai Zheng
    • Jian‑Gang Gao
    • Zhi‑Jun Liu
    • Xin‑Hong Zhang
    • Shuai Wu
    • Bo‑Wen Weng
    • You‑Lin Wang
    • Si‑Chuan Hou
    • Bo Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong 266071, P.R. China
  • Pages: 1845-1850
    |
    Published online on: December 30, 2015
       https://doi.org/10.3892/mmr.2015.4746
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Abstract

The aim of the present study was to investigate the effect of fatty acid synthase complex (FASN) on the migration capacity of bladder transitional cell carcinoma (BTCC) cells and the involvement of matrix metalloproteinase‑9 (MMP‑9) via targeting of phospho‑AKT (p‑AKT). FASN‑specific small‑interfering RNA (FASN‑siRNA) was used to inhibit FASN gene expression in the 5637 and 253J BTCC cell lines. The knockdown efficiency of FAM‑conjugated FASN‑siRNA was confirmed by fluorescence microscopy. The migratory abilities of BTCC cells were assessed using a Transwell assay. Furthermore, protein and mRNA expression of FASN, p‑AKT, AKT, and migration‑associated protein MMP‑9 were detected by western blot analysis. Treatment with FASN inhibitor Cer and FASN‑siRNA decreased the migratory capacity of bladder cancer cells and reduced the levels of p‑AKT as well as the expression of MMP‑9. These results indicated that FASN inhibition suppressed the migratory capacity of BTCC cells through suppressing AKT activation and consequently reducing MMP‑9 expression. Targeting FASN may represent a promising novel therapeutic strategy for BTCC.
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1 

Shariat SF, Karakiewicz PI, Palapattu GS, Lotan Y, Rogers CG, Amiel GE, Vazina A, Gupta A, Bastian PJ, Sagalowsky AI, et al: Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: A contemporary series from the Bladder Cancer Research Consortium. J Urol. 176:2414–2422. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Madersbacher S, Hochreiter W, Burkhard F, Thalmann GN, Danuser H, Markwalder R and Studer UE: Radical cystectomy for bladder cancer today-a homogeneous series without neoad-juvant therapy. J Clin Oncol. 21:690–696. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Philips GK, Halabi S, Sanford BL, Bajorin D and Small EJ; Cancer and Leukemia Group B: A phase II trial of cisplatin (C), gemcitabine (G) and gefitinib for advanced urothelial tract carcinoma: Results of Cancer and Leukemia Group B (CALGB) 90102. Ann Oncol. 20:1074–1079. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Wu M, Dickinson SI, Wang X and Zhang J: Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder. Int J Clin Exp Pathol. 7:6504–6513. 2014.PubMed/NCBI

5 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar

6 

Kuhajda FP, Jenner K, Wood FD, Hennigar RA, Jacobs LB, Dick JD and Pasternack GR: Fatty acid synthesis: A potential selective target for antineoplastic therapy. Proc Natl Acad Sci USA. 91:6379–6383. 1994. View Article : Google Scholar : PubMed/NCBI

7 

Wakil SJ: Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry. 28:4523–4530. 1989. View Article : Google Scholar : PubMed/NCBI

8 

Kuhajda FP: Fatty acid synthase and cancer: New application of an old pathway. Cancer Res. 66:5977–5980. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Orita H, Coulter J, Lemmon C, Tully E, Vadlamudi A, Medghalchi SM, Kuhajda FP and Gabrielson E: Selective inhibition of fatty acid synthase for lung cancer treatment. Clin Cancer Res. 13:7139–7145. 2007.PubMed/NCBI

10 

Abdel-Magid AF: Fatty acid synthase (FASN) inhibitors as potential treatment for cancer, obesity, and liver related disorders. ACS Med Chem Lett. 6:838–839. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Jiang B, Li EH, Lu YY, Jiang Q, Cui D, Jing YF and Xia SJ: Inhibition of fatty-acid synthase suppresses P-AKT and induces apoptosis in bladder cancer. Urology. 80:484.e9–e15. 2012. View Article : Google Scholar

12 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

13 

Saeb-Parsy K, Veerakumarasivam A, Wallard MJ, Thorne N, Kawano Y, Murphy G, Neal DE, Mills IG and Kelly JD: MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3. Br J Cancer. 99:663–669. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Di Carlo A, Terracciano D, Mariano A and Macchia V: Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors. Oncol Rep. 15:1321–1326. 2006.PubMed/NCBI

15 

Houédé N and Pourquier P: Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: Its potential use in the treatment of bladder cancers. Pharmacol Ther. 145:1–18. 2015. View Article : Google Scholar

16 

Chen M, Gu J, Delclos GL, Killary AM, Fan Z, Hildebrandt MA, Chamberlain RM, Grossman HB, Dinney CP and Wu X: Genetic variations of the PI3K-AKT-mTOR pathway and clinical outcome in muscle invasive and metastatic bladder cancer patients. Carcinogenesis. 31:1387–1391. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Cheng G, Palanisamy AP, Evans ZP, Sutter AG, Jin L, Singh I, May H, Schmidt MG and Chavin KD: Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice. PLoS One. 8:e759802013. View Article : Google Scholar : PubMed/NCBI

18 

Nomura S, Horiuchi T, Hata T and Omura S: Inhibition of sterol and fatty acid biosyntheses by cerulenin in cell-free systems of yeast. J Antibiot (Tokyo). 25:365–368. 1972. View Article : Google Scholar

19 

Valencia-Sanchez MA, Liu J, Hannon GJ and Parker R: Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20:515–524. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Bessadóttir M, Skúladóttir EÁ, Gowan S, Eccles S, Ögmundsdóttir S and Ogmundsdóttir HM: Effects of anti-prolif-erative lichen metabolite, protolichesterinic acid on fatty acid synthase, cell signalling and drug response in breast cancer cells. Phytomedicine. 21:1717–1724. 2014. View Article : Google Scholar

21 

Sadowski MC, Pouwer RH, Gunter JH, Lubik AA, Quinn RJ and Nelson CC: The fatty acid synthase inhibitor triclosan: Repurposing an anti-microbial agent for targeting prostate cancer. Oncotarget. 5:9362–9381. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Veigel D, Wagner R, Stübiger G, Wuczkowski M, Filipits M, Horvat R, Benhamú B, López-Rodríguez ML, Leisser A, Valent P, et al: Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells. Int J Cancer. 136:2078–2090. 2015. View Article : Google Scholar

23 

Jin X, Zhang KJ, Guo X, Myers R, Ye Z, Zhang ZP, Li XF, Yang HS and Xing JL: Fatty acid synthesis pathway genetic variants and clinical outcome of non-small cell lung cancer patients after surgery. Asian Pac J Cancer Prev. 15:7097–7103. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Impheng H, Pongcharoen S, Richert L, Pekthong D and Srisawang P: The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells. PLoS One. 9:e1078422014. View Article : Google Scholar : PubMed/NCBI

25 

Migita T, Ruiz S, Fornari A, Fiorentino M, Priolo C, Zadra G, Inazuka F, Grisanzio C, Palescandolo E, Shin E, et al: Fatty acid synthase: A metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst. 101:519–532. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Menendez JA, Vellon L, Mehmi I, Oza BP, Ropero S, Colomer R and Lupu R: Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci USA. 101:10715–10720. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Murata S, Yanagisawa K, Fukunaga K, Oda T, Kobayashi A, Sasaki R and Ohkohchi N: Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice. Cancer Sci. 101:1861–1865. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Zeng L, Biernacka KM, Holly JM, Jarrett C, Morrison AA, Morgan A, Winters ZE, Foulstone EJ, Shield JP and Perks CM: Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: The role of fatty acid synthase. Endocr Relat Cancer. 17:539–551. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Murata S, Yanagisawa K, Fukunaga K, Oda T, Kobayashi A, Sasaki R and Ohkohchi N: Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice. Cancer Sci. 101:1861–1865. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Wellberg EA, Rudolph MC, Lewis AS, Padilla-Just N, Jedlicka P and Anderson SM: Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14, is associated with altered growth and metastasis. Breast Cancer Res. 16:4812014. View Article : Google Scholar

31 

Valastyan S and Weinberg RA: Tumor metastasis: Molecular insights and evolving paradigms. Cell. 147:275–292. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Nabeshima K, Inoue T, Shimao Y and Sameshima T: Matrix metalloproteinases in tumor invasion: Role for cell migration. Pathol Int. 52:255–264. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Overall CM and Kleifeld O: Tumour microenvironment-opinion: Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer. 6:227–239. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Egeblad M and Werb Z: New functions for the matrix metallopro-teinases in cancer progression. Nat Rev Cancer. 2:161–174. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Kumar B, Koul S, Petersen J, Khandrika L, Hwa JS, Meacham RB, Wilson S and Koul HK: p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity. Cancer Res. 70:832–841. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Offersen BV, Knap MM, Horsman MR, Verheijen J, Hanemaaijer R and Overgaard J: Matrix metalloproteinase-9 measured in urine from bladder cancer patients is an independent prognostic marker of poor survival. Acta Oncol. 49:1283–1287. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Donmez G, Sullu Y, Baris S, Yildiz L, Aydin O, Karagoz F and Kandemir B: Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) and thrombospondin-1 (TSP-1) expression in urothelial carcinomas. Pathol Res Pract. 205:854–857. 2009. View Article : Google Scholar

39 

Vasala K, Pääkko P and Turpeenniemi-Hujanen T: Matrix metal-loproteinase-9 (MMP-9) immunoreactive protein in urinary bladder cancer: A marker of favorable prognosis. Anticancer Res. 28(3B): 1757–1761. 2008.PubMed/NCBI

40 

Martelli AM, Tazzari PL, Evangelisti C, Chiarini F, Blalock WL, Billi AM, Manzoli L, McCubrey JA and Cocco L: Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: From bench to bedside. Curr Med Chem. 14:2009–2023. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Engelman JA, Luo J and Cantley LC: The evolution of phospha-tidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 7:606–619. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Carneiro BA, Meeks JJ, Kuzel TM, Scaranti M, Abdulkadir SA and Giles FJ: Emerging therapeutic targets in bladder cancer. Cancer Treat Rev. 41:170–178. 2015. View Article : Google Scholar

43 

Paplomata E and O'Regan R: The PI3K/AKT/mTOR pathway in breast cancer. Targets, trials and biomarkers. 154–166. 2014.

44 

Chen H, Yang X, Feng Z, Tang R, Ren F, Wei K and Chen G: Prognostic value of caspase-3 expression in cancers of digestive tract: A meta-analysis and systematic review. Int J Clin Exp Med. 8:10225–10234. 2015.PubMed/NCBI

45 

Wu S, Ju GQ, Du T, Zhu YJ and Liu GH: Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo. PLoS One. 8:e613662013. View Article : Google Scholar : PubMed/NCBI

46 

Jeong JW, Jin CY, Park C, Han MH, Kim GY, Moon SK, Kim CG, Jeong YK, Kim WJ, Lee JD and Choi YH: Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt. Int J Oncol. 40:1697–1704. 2012.PubMed/NCBI

47 

Swinnen JV, Van Veldhoven PP, Timmermans L, De Schrijver E, Brusselmans K, Vanderhoydonc F, Van de Sande T, Heemers H, Heyns W and Verhoeven G: Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. Biochem Biophys Res Commun. 302:898–903. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zheng SS, Gao JG, Liu ZJ, Zhang XH, Wu S, Weng BW, Wang YL, Hou SC and Jiang B: Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho‑AKT in bladder cancer. Mol Med Rep 13: 1845-1850, 2016.
APA
Zheng, S., Gao, J., Liu, Z., Zhang, X., Wu, S., Weng, B. ... Jiang, B. (2016). Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho‑AKT in bladder cancer. Molecular Medicine Reports, 13, 1845-1850. https://doi.org/10.3892/mmr.2015.4746
MLA
Zheng, S., Gao, J., Liu, Z., Zhang, X., Wu, S., Weng, B., Wang, Y., Hou, S., Jiang, B."Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho‑AKT in bladder cancer". Molecular Medicine Reports 13.2 (2016): 1845-1850.
Chicago
Zheng, S., Gao, J., Liu, Z., Zhang, X., Wu, S., Weng, B., Wang, Y., Hou, S., Jiang, B."Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho‑AKT in bladder cancer". Molecular Medicine Reports 13, no. 2 (2016): 1845-1850. https://doi.org/10.3892/mmr.2015.4746
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng SS, Gao JG, Liu ZJ, Zhang XH, Wu S, Weng BW, Wang YL, Hou SC and Jiang B: Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho‑AKT in bladder cancer. Mol Med Rep 13: 1845-1850, 2016.
APA
Zheng, S., Gao, J., Liu, Z., Zhang, X., Wu, S., Weng, B. ... Jiang, B. (2016). Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho‑AKT in bladder cancer. Molecular Medicine Reports, 13, 1845-1850. https://doi.org/10.3892/mmr.2015.4746
MLA
Zheng, S., Gao, J., Liu, Z., Zhang, X., Wu, S., Weng, B., Wang, Y., Hou, S., Jiang, B."Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho‑AKT in bladder cancer". Molecular Medicine Reports 13.2 (2016): 1845-1850.
Chicago
Zheng, S., Gao, J., Liu, Z., Zhang, X., Wu, S., Weng, B., Wang, Y., Hou, S., Jiang, B."Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho‑AKT in bladder cancer". Molecular Medicine Reports 13, no. 2 (2016): 1845-1850. https://doi.org/10.3892/mmr.2015.4746
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