Association of HNF4α gene polymorphisms with susceptibility to type 2 diabetes

Ma,Run; Yang,Hongying; Li,Jingfang; Yang,Xu; Chen,Xiaohong; Hu,Ying; Wang,Zhou; Xue,Li; Zhou,Wei

doi:10.3892/mmr.2016.4780

Association of HNF4α gene polymorphisms with susceptibility to type 2 diabetes

Authors:
- Run Ma
- Hongying Yang
- Jingfang Li
- Xu Yang
- Xiaohong Chen
- Ying Hu
- Zhou Wang
- Li Xue
- Wei Zhou
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Affiliations: Clinical Laboratory, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, P.R. China, Clinical Laboratory, Cancer Hospital of Yunnan Province, Kunming, Yunnan 650118, P.R. China, Department of Ophthalmology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan 650011, P.R. China
Published online on: January 13, 2016 https://doi.org/10.3892/mmr.2016.4780
Pages: 2241-2246

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Abstract

The present study aimed to explore the association between single nucleotide polymorphisms (SNPs) in the hepatocyte nuclear factor‑4α (HNF‑4α) gene and the incidence of type 2 diabetes in the Chinese Bai population in Dali city, China. The polymerase chain reaction‑restriction fragment length polymorphism method was used to analyze four SNPs (rs4810424, rs1884613, rs1884614 and rs2144908) in the HNF‑4α gene in 44 patients with type 2 diabetes and 87 healthy controls in Chinese Bai individuals. The haploid type was subsequently built to assess its association with the incidence of type 2 diabetes in the Bai population in Dali city. No significant differences were observed between the genotype and allele frequencies of the four SNPs in the HNF‑4α gene and type 2 diabetes mellitus (P>0.05). However, the frequency of haplotype, CCTA, built by rs4810424, rs1884613, rs1884614 and rs2144908 was significantly higher in the type 2 diabetes mellitus group compared with the control group (χ2=8.34, P=0.004). The four polymorphisms, rs4810424, rs1884613, rs1884614 and rs2144908, in the HNF‑4α gene were not the susceptible loci for type 2 diabetes in the Bai population of Dali city, however, the haplotype, CCTA, built from the four SNPs may increase the risk of type 2 diabetes in this population.

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