GRHL2 genetic polymorphisms may confer a protective effect against sudden sensorineural hearing loss

  • Authors:
    • Xiaojiang Lin
    • Yaoshu Teng
    • Jinshan Lan
    • Benjun He
    • Huijuan Sun
    • Fenglin Xu
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  • Published online on: February 5, 2016     https://doi.org/10.3892/mmr.2016.4871
  • Pages: 2857-2863
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Abstract

Genetic polymorphisms in grainyhead‑like 2 (GRHL2) variants were examined for their suspected association with sudden sensorineural hearing loss (SSHL). Between January 2009 and April 2014, 190 patients with SSHL, who were diagnosed at the Departments of Otorhinolaryngology Head and Neck Surgery at Kaihua People's Hospital and Hangzhou First People's Hospital, were selected for the present study and defined as the SSHL group. A group of 210 healthy individuals were defined as the control group. Polymerase chain reaction (PCR)‑restriction fragment length polymorphism was used to detect GRHL2 genotypes, using genomic DNA isolated from peripheral blood as PCR templates. GRHL2 rs611419 genetic polymorphisms conferred a protective effect against SSHL (AT+TT vs. AA: OR=0.63, 95% CI=0.41‑0.98, P=0.038). In addition, rs10955255 polymorphisms were associated with a reduced risk of SSHL (AA vs. GG: OR=0.54, 95% CI=0.31‑0.95, P=0.032; GA+AA vs. GG: OR=0.58, 95% CI=0.38‑0.89, P=0.012). Combined genotypes of rs611419, rs10955255 and rs6989650 in the GRHL2 gene are also associated with a reduced risk of SSHL (P=0.035). In subjects who consumed alcohol, co‑occurrence of 3‑8 variant alleles conferred increased resistance to SSHL, compared with the occurrence of 0‑2 variant alleles (OR=0.40, 95% CI=0.21‑0.76, P=0.004). GRHL2 genetic polymorphisms, rs611419 and rs10955255, have a protective role against SSHL and reduce the risk of SSHL. However, rs6989650 is not associated with SSHL.
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March-2016
Volume 13 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Lin X, Teng Y, Lan J, He B, Sun H and Xu F: GRHL2 genetic polymorphisms may confer a protective effect against sudden sensorineural hearing loss. Mol Med Rep 13: 2857-2863, 2016.
APA
Lin, X., Teng, Y., Lan, J., He, B., Sun, H., & Xu, F. (2016). GRHL2 genetic polymorphisms may confer a protective effect against sudden sensorineural hearing loss. Molecular Medicine Reports, 13, 2857-2863. https://doi.org/10.3892/mmr.2016.4871
MLA
Lin, X., Teng, Y., Lan, J., He, B., Sun, H., Xu, F."GRHL2 genetic polymorphisms may confer a protective effect against sudden sensorineural hearing loss". Molecular Medicine Reports 13.3 (2016): 2857-2863.
Chicago
Lin, X., Teng, Y., Lan, J., He, B., Sun, H., Xu, F."GRHL2 genetic polymorphisms may confer a protective effect against sudden sensorineural hearing loss". Molecular Medicine Reports 13, no. 3 (2016): 2857-2863. https://doi.org/10.3892/mmr.2016.4871