The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review)
- Authors:
- Kuo Yan
- Li‑Na Gao
- Yuan‑Lu Cui
- Yi Zhang
- Xin Zhou
-
Affiliations: Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China - Published online on: March 18, 2016 https://doi.org/10.3892/mmr.2016.5005
- Pages: 3715-3723
-
Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
|
Conti M and Beavo J: Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem. 76:481–511. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Brown KM, Lee LC, Findlay JE, Day JP and Baillie GS: Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation. FEBS Lett. 586:1631–1637. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Diaz-Muñoz MD, Osma-García IC, Fresno M and Iñiguez MA: Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages. Biochem J. 443:451–461. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Jhala US, Canettieri G, Screaton RA, Kulkarni RN, Krajewski S, Reed J, Walker J, Lin X, White M and Montminy M: cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev. 17:1575–1580. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Beshay E, Croze F and Prud'homme GJ: The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo. Clin Immunol. 98:272–279. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Park PH, Huang H, McMullen MR, Bryan K and Nagy LE: Activation of cyclic-AMP response element binding protein contributes to adiponectin-stimulated interleukin-10 expression in RAW 264.7 macrophages. J Leukoc Biol. 83:1258–1266. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Chang SY, Kim DB, Ryu GR, Ko SH, Jeong IK, Ahn YB, Jo YH and Kim MJ: Exendin-4 inhibits iNOS expression at the protein level in LPS-stimulated Raw264.7 macrophage by the activation of cAMP/PKA pathway. J Cell Biochem. 114:844–853. 2013. View Article : Google Scholar | |
|
Rosethorne EM, Nahorski SR and Challiss RA: Regulation of cyclic AMP response-element binding-protein (CREB) by Gq/11-protein-coupled receptors in human SH-SY5Y neuro-blastoma cells. Biochem Pharmacol. 75:942–955. 2008. View Article : Google Scholar : | |
|
Burdyga A, Conant A, Haynes L, Zhang J, Jalink K, Sutton R, Neoptolemos J, Costello E and Tepikin A: cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: Effects of PKA and EPAC. Biochim Biophys Acta. 1833.2664–2672. 2013. | |
|
Menniti FS, Faraci WS and Schmidt CJ: Phosphodiesterases in the CNS: Targets for drug development. Nat Rev Drug Discov. 5:660–670. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Jang IS, Kang UG, Kim YS, Ahn YM, Park JB and Juhnn YS: Isoform-specific changes of adenylate cyclase mRNA expression in rat brains following chronic electroconvulsive shock. Prog Neuropsychopharmacol Biol Psychiatry. 25:1571–1581. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Gloerich M and Bos JL: Epac: Defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol. 50:355–375. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Nakajima T, Uchida C, Anderson SF, Parvin JD and Montminy M: Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors. Genes Dev. 11:738–747. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Maurice DH, Palmer D, Tilley DG, Dunkerley HA, Netherton SJ, Raymond DR, Elbatarny HS and Jimmo SL: Cyclic nucleotide phosphodiesterase activity, expression and targeting in cells of the cardiovascular system. Mol Pharmacol. 64:533–546. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
McLean JH, Smith A, Rogers S, Clarke K, Darby-King A and Harley CW: A phosphodiesterase inhibitor, cilomilast, enhances cAMP activity to restore conditioned odor preference memory after serotonergic depletion in the neonate rat. Neurobiol Learn Mem. 92:63–69. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Jackson EK and Dubey RK: Role of the extracellular cAMP-adenosine pathway in renal physiology. Am J Physiol Renal Physiol. 281:F597–F612. 2001.PubMed/NCBI | |
|
Seino S and Shibasaki T: PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiol Rev. 85:1303–1342. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Richards JS: New Signaling pathways for hormones and cyclic adenosine 3′,5′-monophosphate action in endocrine cells. Mol Endocrinol. 15:209–218. 2001.PubMed/NCBI | |
|
Guseva D, Wirth A and Ponimaskin E: Cellular mechanisms of the 5-HT7 receptor-mediated signaling. Front Behav Neurosci. 8:3062014. View Article : Google Scholar : PubMed/NCBI | |
|
Patterson SL, Abel T, Deuel TA, Martin KC, Rose JC and Kandel ER: Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron. 16:1137–1145. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Metz R and Ziff E: cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to translocate to the nucleus and induce c-fos transcription. Genes Dev. 5:1754–1766. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Barad M, Bourtchouladze R, Winder DG, Golan H and Kandel E: Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc Natl Acad Sci USA. 95:15020–15025. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Chen CC, Chiu KT, Sun YT and Chen WC: Role of the cyclic AMP-protein kinase a pathway in lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages. J Biol Chem. 274:31559–331564. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Moon EY, Lee JH, Lee JW, Song JH and Pyo S: ROS/Epac1-mediated Rap1/NF-kappaB activation is required for the expression of BAFF in Raw264.7 murine macrophages. Cell Signal. 23:1479–1488. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
DiPilato LM, Cheng X and Zhang J: Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci USA. 101:16513–16518. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Avni D, Ernst O, Philosoph A and Zor T: Role of CREB in modulation of TNFalpha and IL-10 expression in LPS-stimulated RAW264.7 macrophages. Mol Immunol. 47:1396–1403. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Horton JK and Baxendale PM: Mass measurements of cyclic AMP formation by radioimmunoassay, enzyme immunoassay and scintillation proximity assay. Methods Mol Biol. 41:91–105. 1995. | |
|
Costanzo V, Robertson K, Ying CY, Kim E, Avvedimento E, Gottesman M, Grieco D and Gautier J: Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol Cell. 6:649–659. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Costanzo V, Avvedimento EV, Gottesman ME, Gautier J and Grieco D: Protein kinase A is required for chromosomal DNA replication. Curr Biol. 9:903–906. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Smith A, Ward MP and Garrett S: Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation. EMBO J. 17:3556–3564. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Liu F, Verin AD, Borbiev T and Garcia JG: Role of cAMP-dependent protein kinase A activity in endothelial cell cytoskeleton rearrangement. Am J Physiol Lung Cell Mol Physiol. 280:L1309–L1317. 2001.PubMed/NCBI | |
|
Gerits N, Mikalsen T, Kostenko S, Shiryaev A, Johannessen M and Moens U: Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5. J Biol Chem. 282:37232–37243. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Yang W, LV X, Yu S, Guan W, Di D, Wang H and Li J: Effect of cAMP-PKA-CREB signal pathway in the model of alcoholic hepatic fibrosis stellate cells isolated from rats. Anhui Med Pharm J. 16:729–731. 2012. | |
|
Bruce JI, Shuttleworth TJ, Giovannucci DR and Yule DI: Phosphorylation of inositol 1, 4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling. J Biol Chem. 277:1340–1348. 2002. View Article : Google Scholar | |
|
Grønborg M, Kristiansen TZ, Stensballe A, Andersen JS, Ohara O, Mann M, Jensen ON and Pandey A: A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho-specific antibodies: Identification of a novel protein, Frigg, as a protein kinase a substrate. Mol Cell Proteomics. 1:517–527. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Schmitt A and Nebreda AR: Inhibition of Xenopus oocyte meiotic maturation by catalytically inactive protein kinase A. Proc Natl Acad Sci USA. 99:4361–4366. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Lei H, Venkatakrishnan A, Yu S and Kazlauskas A: Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes. J Biol Chem. 282:9364–9371. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Goueli BS, Hsiao K and Goueli ASA: A novel and simple method to assay the activity of individual protein kinases in a crude tissue extract. Methods Mol Med. 39:633–644. 2001.PubMed/NCBI | |
|
Fujikawa H, Kanno T, Nagata T and Nishizaki T: The phosphodiesterase III inhibitor olprinone inhibits hippocampal glutamate release via a cGMP/PKG pathway. Neurosci Lett. 448:208–211. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Kanno T, Yamamoto H, Yaguchi T, Hi R, Mukasa T, Fujikawa H, Nagata T, Yamamoto S, Tanaka A and Nishizaki T: The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site. J Lipid Res. 47:1146–1156. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Brindlet P, Nakajima T and Montminy M: Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP (cAMP response element-binding protein). Proc Natl Acad Sci USA. 92:10521–10525. 1995. View Article : Google Scholar | |
|
Shih HM, Goldman PS, DeMaggio AJ, Hollenberg SM, Goodman RH and Hoekstra MF: A positive genetic selection for disrupting protein-protein interactions: Identification of CREB mutations that prevent association with the coactivator CBP. Proc Natl Acad Sci USA. 93:13896–13901. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Ferreri K, Gillt G and Montminy M: The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex (glutamine-rich activator/TATA binding protein-associated factor dTAF11O). Proc Natl Acad Sci USA. 91:1210–1213. 1994. View Article : Google Scholar | |
|
Ginty DD: Calcium regulation of gene expression: Isn't that spatial? Neuron. 18:183–186. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Parker D, Ferreri K, Nakajima T, LaMorte VJ, Evans R, Koerber SC, Hoeger C and Montminy MR: Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. Mol Cell Biol. 16:694–703. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Silva AJ, Kogan JH, Frankland PW and Kida S: CREB and memory. Neurosci. 21:127–148. 1998. | |
|
Riccio A, Alvania RS, Lonze BE, Ramanan N, Kim T, Huang Y, Dawson TM, Snyder SH and Ginty DD: A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol Cell. 21:283–294. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Moon EY, Lee YS, Choi WS and Lee MH: Toll-like receptor 4-mediated cAMP production up-regulates B-cell activating factor expression in Raw264.7 macrophages. Exp Cell Res. 317:2447–2455. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Deng H, Zhang N, Wang Y, Chen J, Shen J, Wang Z, Xu R, Zhang J, Song D and Li D: S632A3, a new glutarimide antibiotic, suppresses lipopolysaccharide-induced pro-inflammatory responses via inhibiting the activation of glycogen synthase kinase 3β. Exp Cell Res. 318:2592–2603. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Wang QS, Tian JS, Cui YL and Gao S: Genipin is active via modulating monoaminergic transmission and levels of brain-derived neurotrophic factor (BDNF) in rat model of depression. Neuroscience. 275:365–373. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Xu G, Tu W and Qin AS: The relationship between deiodinase activity and inflammatory responses under the stimulation of uremic toxins. J Transl Med. 12:2392014. View Article : Google Scholar : PubMed/NCBI | |
|
Fang JQ, Jun JF, Liang Y and Du JY: Electroacupuncture mediates extracellular signalregulated kinase 1/2 pathways in the spinal cord of rats with inflammatory pain. BMC Complement Altern Med. 14:2852014. View Article : Google Scholar | |
|
Guan CX, Cui YR, Sun GY, Yu F, Tang CY, Li YC, Liu HJ and Fang X: Role of CREB in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells. Regul Pept. 153:64–69. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Yu T, Lee YG, Yang WS, Oh J, Jeong D, Lee S, Kim TW, Park YC, Sung GH and Cho JY: Methanol extract of Hopea odorata suppresses inflammatory responses via the direct inhibition of multiple kinases. J Ethnopharmacol. 145:598–607. 2013. View Article : Google Scholar | |
|
Carey MF, Peterson CL and Smale ST: Chromatin immunoprecipitation (ChIP). Cold Spring Harb Protoc. 2009.pdb prot52792009. | |
|
Andreeva SG, Dikkes P, Epstein PM and Rosenberg PA: Expression of cGMP-Specific Phosphodiesterase 9A mRNA in the rat brain. J Neurosci. 21:9068–9076. 2001.PubMed/NCBI | |
|
Lugnier C: Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents. Pharmacol Ther. 109:366–398. 2006. View Article : Google Scholar | |
|
Nanda K, Chatterjee M, Arya R, Mukherjee S, Saini KS, Dastidar S and Ray A: Optimization and validation of a reporter gene assay for screening of phosphodiesterase inhibitors in a high throughput system. Biotechnol J. 3:1276–1279. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Page CP and Spina D: Selective PDE inhibitors as novel treatments for respiratory diseases. Curr Opin Pharmacol. 12:275–286. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Pinner NA, Hamilton LA and Hughes A: Roflumilast: A phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease. Clin Ther. 34:56–66. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Spina D: PDE4 inhibitors: Current status. Br J Pharmacol. 155:308–315. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M and Marks AR: Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 123:25–35. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Peter D, Jin SL, Conti M, Hatzelmann A and Zitt C: Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: Predominant role of PDE4D. J Immunol. 178:4820–4831. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Takahashi M, Terwilliger R, Lane C, Mezes PS, Conti M and Duman RS: Chronic antidepressant administration increases the expression of cAMP-specific phosphodiesterase 4A and 4B isoforms. J Neurosci. 19:610–618. 1999.PubMed/NCBI | |
|
Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC and Lenz LL: MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 187:2595–2601. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Guo H, Sayed MD, Lu Y, Yang T, Zhou D, Chen Z, Wang H, Wang C and Xu J: cAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in rats. Neuropsychiatr Dis Treat. 12:219–227. 2016.PubMed/NCBI | |
|
Kono Y and Hülsmann S: Presynaptic facilitation of glycinergic mIPSC is reduced in mice lacking α3 glycine receptor subunits. Neuroscience. 320:1–7. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K, Chen Z, Uhler MD, Rui L, Gonzalez FJ and Shah YM: HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling. Cell Metab. Feb 3–2016.Epub ahead of print. View Article : Google Scholar | |
|
Pal S, Khan K, China SP, Mittal M, Shrivastava R, Taneja I, Hossain Z, Mandalapu D, Gayen JR, et al: Theophylline, a methylxanthine drug induces osteopenia and alters calciotropic hormones, and prophylactic vitamin D treatment protects against these changes in rats. Toxicol Appl Pharmacol. Feb 3–2016.Epub ahead of print. View Article : Google Scholar | |
|
Bobin P, Varin A, Lefebvre F, Fischmeister R, Vandecasteele G and Leroy J: Calmodulin kinase II inhibition limits the pro-arrhythmic Ca2+ waves induced by cAMP-phosphodiesterase inhibitors. Cardiovasc Res. Feb 4–2016.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI | |
|
Osawa Y, Lee HT, Hirshman CA, Xu D and Emala CW: Lipopolysaccharide-induced sensitization of adenylyl cyclase activity in murine macrophages. Am J Physiol Cell Physiol. 290:C143–C151. 2006. View Article : Google Scholar | |
|
Kobayashi Y, Mizoguchi T, Take I, Kurihara S, Udagawa N and Takahashi N: Prostaglandin E2 enhances osteoclastic differentiation of precursor cells through protein kinase A-dependent phosphorylation of TAK1. J Biol Chem. 280:11395–11403. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Malbon CC and Graziano MP: Adenosine deaminase normalizes cyclic AMP responses of hypothyroid rat fat cells to forskolin, but not beta-adrenergic agonists. FEBS Lett. 155:35–38. 1983. View Article : Google Scholar : PubMed/NCBI | |
|
Jeon SH, Chae BC, Kim HA, Seo GY, Seo DW, Chun GT, Yie SW, Eom SH and Kim PH: The PKA/CREB Pathway is closely involved in VEGF expression in mouse macrophages. Mol Cells. 23:23–29. 2007.PubMed/NCBI | |
|
Burgos-Ramos E, Hervás-Aguilar A, Puebla-Jiménez L, Boyano-Adánez MC and Arilla-Ferreiro E: Chronic but not acute intracerebroventricular administration of amyloid beta-peptide 25–35 decreases somatostatin content, adenylate cyclase activity, somatostatin-induced inhibition of adenylate cyclase activity and adenylate cyclase I levels in the rat hippocampus. J Neurosci Res. 85:433–442. 2007. View Article : Google Scholar | |
|
Tajima T, Murata T, Aritake K, Urade Y, Michishita M, Matsuoka T, Narumiya S, Ozaki H and Hori M: EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals. Am J Physiol Gastrointest Liver Physiol. 302:G524–G534. 2012. View Article : Google Scholar : | |
|
Okado-Matsumoto A, Matsumoto A, Fujii J and Taniguchi N: Effect of cAMP on inducible nitric oxide synthase gene expression: Its dual and cell-specific functions. Antioxid Redox Signal. 2:631–642. 2000. View Article : Google Scholar | |
|
Mukhopadhyay S, Das S, Williams EA, Moore D, Jones JD, Zahm DS, Ndengele MM, Lechner AJ and Howlett AC: Lipopolysaccharide and cyclic AMP regulation of CB(2) cannabinoid receptor levels in rat brain and mouse RAW 264.7 macrophages. J Neuroimmunol. 181:82–92. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Goldsmith M, Avni D, Ernst O, Glucksam Y, Levy-Rimler G, Meijler MM and Zor T: Synergistic IL-10 induction by LPS and the ceramide-1-phosphate analog PCERA-1 is mediated by the cAMP and p38 MAP kinase pathways. Mol Immunol. 46:1979–1987. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Cho IJ, Woo NR, Shin IC and Kim SG: H89, an inhibitor of PKA and MSK, inhibits cyclic-AMP response element binding protein-mediated MAPK phosphatase-1 induction by lipopolysaccharide. Inflamm Res. 58:863–872. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Ma J, Chen M, Xia SK, Shu W, Guo Y, Wang YH, Xu Y, Bai XM, Zhang L, Zhang H, et al: Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression. Int J Oncol. 42:1093–1104. 2013.PubMed/NCBI | |
|
Kotomi F, Kotera J, Michibata H, Yuasa K, Takebayashi S, Okumura K and Omori K: Cloning and Characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J Biol Chem. 274:18438–18445. 1999. View Article : Google Scholar | |
|
Wheeler MA, Ayyagari RR, Wheeler GL and Weiss RM: Regulation of cyclic nucleotides in the urinary tract. J Smooth Muscle Res. 41:1–21. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Lerner A and Epstein PM: Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies. Biochem J. 393:21–41. 2006. View Article : Google Scholar : | |
|
Dousa TP: Cyclic-3′,5′-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney. Kidney Int. 55:29–62. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Lipworth BJ: Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease. Lancet. 365:167–175. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Dastidar SG, Rajagopal D and Ray A: Therapeutic benefit of PDE4 inhibitors in inflammatory diseases. Curr Opin Investig Drugs. 8:364–372. 2007.PubMed/NCBI | |
|
Bielekova B, Lincoln A, McFarland H and Martin R: Therapeutic potential of phosphodiesterase-4 and-3 inhibitors in Th1-mediated autoimmune diseases. J Immunol. 164:1117–1124. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Avni D, Philosoph A, Meijler MM and Zor T: The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner. Immunology. 129:375–385. 2010. View Article : Google Scholar : | |
|
Sosroseno W, Musa M, Ravichandran M, Fikri Ibrahim M, Bird PS and Seymour GJ: The role of cyclic-AMP on arginase activity by a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 21:347–352. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Navakkode S, Sajikumar S and Frey JU: Mitogen-activated protein kinase-mediated reinforcement of hippocampal early long-term depression by the type IV-specific phosphodies-terase inhibitor rolipram and its effect on synaptic tagging. J Neurosci. 25:10664–10670. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Chi ZL, Hayasaka S, Zhang XY, Hayasaka Y and Cui HS: Effects of rolipram, a selective inhibitor of type 4 phosphodiesterase, on lipopolysaccharide-induced uveitis in rats. Invest Ophthalmol Vis Sci. 45:2497–2502. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Yoshimura K, Hiramatsu Y and Murakami M: Cyclic AMP potentiates substance P-induced amylase secretion by augmenting the effect of calcium in the rat parotid acinar cells. Biochim Biophys Acta. 1402:171–187. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Gobejishvili L, Avila DV, Barker DF, Ghare S, Henderson D, Brock GN, Kirpich IA, Joshi-Barve S, Mokshagundam SP, McClain CJ and Barve S: S-adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and attenuates tumor necrosis factor expression via cAMP/protein kinase A pathway. J Pharmacol Exp Ther. 337:433–443. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Liou SF, Hsu JH, Lin IL, Ho ML, Hsu PC, Chen LW, Chen IJ and Yeh JL: KMUP-1 suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss: Roles of MAPKs, Akt, NF-kB and calcium/calcineurin/NFATc1 pathways. PLoS One. 8:e694682013. View Article : Google Scholar | |
|
Hamblin JN, Angell TD, Ballantine SP, Cook CM, Cooper AW, Dawson J, Delves CJ, Jones PS, Lindvall M, Lucas FS, et al: Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors. Bioorg Med Chem Lett. 18:4237–4241. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Park WS, Jung WK, Lee DY, Moon C, Yea SS, Park SG, Seo SK, Park C, Choi YH, Kim GY, et al: Cilostazol protects mice against endotoxin shock and attenuates LPS-induced cytokine expression in RAW 264.7 macrophages via MAPK inhibition and NF-kappaB inactivation: Not involved in cAMP mechanisms. Int Immunopharmacol. 10:1077–1085. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Dong H, Osmanova V, Epstein PM and Brocke S: Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes. Biochem Biophys Res Commun. 345:713–719. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Wunder F, Stasch JP, Hütter J, Alonso-Alija C, Hüser J and Lohrmann E: A cell-based cGMP assay useful for ultra-high-throughput screening and identification of modulators of the nitric oxide/cGMP pathway. Anal Biochem. 339:104–112. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Lallemend F, Lefebvre PP, Hans G, Rigo JM, Van de Water TR, Moonen G and Malgrange B: Substance P protects spiral ganglion neurons from apoptosis via PKC-Ca2+-MAPK/ERK pathways. J Neurochem. 87:508–521. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Gilmore TD: Introduction to NF-kappaB: Players, pathways, perspectives. Oncogene. 25:6680–6684. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Denninger JW and Marletta MA: Guanylate cyclase and the. NO/cGMP signaling pathway. Biochim Biophys Acta. 1411:334–350. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Edgar VA, Cremaschi GA, Sterin-Borda L and Genaro AM: Altered expression of autonomic neurotransmitter receptors and proliferative responses in lymphocytes from a chronic mild stress model of depression: Effects of fluoxetine. Brain Behav Immun. 16:333–350. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Reierson GW, Mastronardi CA, Licinio J and Wong ML: Repeated antidepressant therapy increases cyclic GMP signaling in rat hippocampus. Neurosci Lett. 466:149–153. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Lee AK, Sung SH, Kim YC and Kim SG: Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. Br J Pharmacol. 139:11–20. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Zandi E, Rothwarf DM, Delhase M, Hayakawa M and Karin M: The IkB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, Necessary for IkappaB Phosphorylation and NF-kappaB activation. Cell. 91:243–252. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Chen BC, Liao CC, Hsu MJ, Liao YT, Lin CC, Sheu JR and Lin CH: Peptidoglycan-induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B Kinase and NF-kappa B. J Immunol. 177:681–693. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Ollivier V, Parry GC, Cobb RR, de Prost D and Mackman N: Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells. J Biol Chem. 271:20828–20835. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Hofer AM and Lefkimmiatis K: Extracellular calcium and cAMP: Second messengers as 'third messengers'? Physiology (Bethesda). 22:320–327. 2007. View Article : Google Scholar | |
|
Bhalla US and Iyengar R: Emergent properties of networks of biological signaling pathways. Science. 283:381–387. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Landa LR Jr, Harbeck M, Kaihara K, Chepurny O, Kitiphongspattana K, Graf O, Nikolaev VO, Lohse MJ, Holz GG and Roe MW: Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. J Biol Chem. 280:31294–31302. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Moore TM, Chetham PM, Kelly JJ and Stevens T: Signal transduction and regulation of lung endothelial cell permeability. Interaction between calcium and cAMP. Am J Physiol. 275:L203–L222. 1998.PubMed/NCBI | |
|
Henley JR, Huang KH, Wang D and Poo MM: Calcium mediates bidirectional growth cone turning induced by myelin-associated glycoprotein. Neuron. 44:909–916. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Vajanaphanich M, Schultz C, Tsien RY, Traynor-Kaplan AE, Pandol SJ and Barrett KE: Cross-talk between calcium and cAMP-dependent intracellular signaling pathways. Implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells. J Clin Invest. 96:386–393. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Kapur R, Giuliano KA, Campana M, Adams T, Olson K, Jung D, Mrksich M, Chandrasekaran V and Taylor DL: Streamlining the drug discovery process by integrating miniaturization, high throughput screening, high content screening, and automation on the CellChip™ system. Biomed Microdevices. 2:99–109. 1999. View Article : Google Scholar | |
|
Edwards BS, Oprea T, Prossnitz ER and Sklar LA: Flow cytometry for high-throughput, high-content screening. Curr Opin Chem Biol. 8:392–398. 2004. View Article : Google Scholar : PubMed/NCBI |
