Bruton's tyrosine kinase inhibitor restrains Wnt signaling in chronic lymphocytic leukemia

  • Authors:
    • Pei‑Pei Li
    • Kang Lu
    • Ling‑Yun Geng
    • Xiang‑Xiang Zhou
    • Xin‑Yu Li
    • Xin Wang
  • View Affiliations

  • Published online on: April 12, 2016     https://doi.org/10.3892/mmr.2016.5111
  • Pages: 4934-4938
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Abstract

The B-cell receptor (BCR) signaling pathway serves an important role in the pathogenesis of chronic lymphocytic leukemia (CLL), and has been identified as a novel and effective therapeutic target of CLL, with particular focus its kinase factor, BTK. Previous studies have focused on combining the BTK inhibitor with additional chemotherapeutic agents to improve the prognosis of patients with CLL. Further investigation into the mechanism of the BTK inhibitor would promote an understanding of the pathogenesis of CLL. The current study investigated the association between ibrutinib and the Wnt signaling pathway, additionally focussing upon one of its regulators, metadherin (MTDH), which has been identified to be overexpressed in CLL and is considered a promoter of the Wnt pathway. The experiments in the current study were performed in the MEC-1 CLL cell line. Results indicated that MTDH, β-catenin and lymphoid-enhancing factor-1 were inhibited subsequent to ibrutinib treatment. The results indicate that in CLL, ibrutinib is likely to possess an inhibitory role in Wnt signaling.
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June-2016
Volume 13 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li PP, Lu K, Geng LY, Zhou XX, Li XY and Wang X: Bruton's tyrosine kinase inhibitor restrains Wnt signaling in chronic lymphocytic leukemia. Mol Med Rep 13: 4934-4938, 2016
APA
Li, P., Lu, K., Geng, L., Zhou, X., Li, X., & Wang, X. (2016). Bruton's tyrosine kinase inhibitor restrains Wnt signaling in chronic lymphocytic leukemia. Molecular Medicine Reports, 13, 4934-4938. https://doi.org/10.3892/mmr.2016.5111
MLA
Li, P., Lu, K., Geng, L., Zhou, X., Li, X., Wang, X."Bruton's tyrosine kinase inhibitor restrains Wnt signaling in chronic lymphocytic leukemia". Molecular Medicine Reports 13.6 (2016): 4934-4938.
Chicago
Li, P., Lu, K., Geng, L., Zhou, X., Li, X., Wang, X."Bruton's tyrosine kinase inhibitor restrains Wnt signaling in chronic lymphocytic leukemia". Molecular Medicine Reports 13, no. 6 (2016): 4934-4938. https://doi.org/10.3892/mmr.2016.5111