1
|
Goldberg RB: Cytokine and cytokine-like
inflammation markers, endothelial dysfunction, and imbalanced
coagulation in development of diabetes and its complications. J
Clin Endocrinol Metab. 94:3171–3182. 2009. View Article : Google Scholar : PubMed/NCBI
|
2
|
Conway EM: Thrombomodulin and its role in
inflammation. Semin Immunopathol. 34:107–125. 2012. View Article : Google Scholar
|
3
|
Mangan S, Clancy P and Golledge J:
Modulation of endothelial cell thrombomodulin by PPAR ligands -
variation according to environment. Thromb Res. 121:827–834. 2008.
View Article : Google Scholar
|
4
|
Kondo K, Ishida T, Yasuda T, Nakajima H,
Mori K, Tanaka N, Mori T, Monguchi T, Shinohara M, Irino Y, et al:
Trans-fatty acid promotes thrombus formation in mice by aggravating
antithrom-bogenic endothelial functions via Toll-like receptors.
Mol Nutr Food Res. 59:729–740. 2015. View Article : Google Scholar
|
5
|
He X, Xu Z, Wang B, Zheng Y, Gong W, Huang
G, Zhang L, Li Y and He F: Upregulation of thrombomodulin
expression by activation of farnesoid X receptor in vascular
endothelial cells. Eur J Pharmacol. 718:283–289. 2013. View Article : Google Scholar : PubMed/NCBI
|
6
|
Szanto A and Roszer T: Nuclear receptors
in macrophages: A link between metabolism and inflammation. FEBS
Lett. 582:106–116. 2008. View Article : Google Scholar
|
7
|
Calkin AC and Tontonoz P: Liver x receptor
signaling pathways and atherosclerosis. Arterioscler Thromb Vasc
Biol. 30:1513–1518. 2010. View Article : Google Scholar : PubMed/NCBI
|
8
|
Joseph SB, Castrillo A, Laffitte BA,
Mangelsdorf DJ and Tontonoz P: Reciprocal regulation of
inflammation and lipid metabolism by liver X receptors. Nat Med.
9:213–219. 2003. View
Article : Google Scholar : PubMed/NCBI
|
9
|
Peet DJ, Turley SD, Ma W, Janowski BA,
Lobaccaro JM, Hammer RE and Mangelsdorf DJ: Cholesterol and bile
acid metabolism are impaired in mice lacking the nuclear oxysterol
receptor LXR alpha. Cell. 93:693–704. 1998. View Article : Google Scholar : PubMed/NCBI
|
10
|
Fowler AJ, Sheu MY, Schmuth M, Kao J,
Fluhr JW, Rhein L, Collins JL, Willson TM, Mangelsdorf DJ, Elias PM
and Feingold KR: Liver X receptor activators display
anti-inflammatory activity in irritant and allergic contact
dermatitis models: liver-X-receptor-specific inhibition of
inflammation and primary cytokine production. J Invest Dermatol.
120:246–255. 2003. View Article : Google Scholar : PubMed/NCBI
|
11
|
Joseph SB, Bradley MN, Castrillo A, Bruhn
KW, Mak PA, Pei L, Hogenesch J, O'connell RM, Cheng G, Saez E, et
al: LXR-dependent gene expression is important for macrophage
survival and the innate immune response. Cell. 119:299–309. 2004.
View Article : Google Scholar : PubMed/NCBI
|
12
|
Valledor AF, Hsu LC, Ogawa S,
Sawka-Verhelle D, Karin M and Glass CK: Activation of liver X
receptors and retinoid X receptors prevents bacterial-induced
macrophage apoptosis. Proc Natl Acad Sci USA. 101:17813–17818.
2004. View Article : Google Scholar : PubMed/NCBI
|
13
|
Baranowski M: Biological role of liver X
receptors. J Physiol Pharmacol. 59(Suppl 7): 31–55. 2008.
|
14
|
Yang SM, Ka SM, Wu HL, Yeh YC, Kuo CH, Hua
KF, Shi GY, Hung YJ, Hsiao FC, Yang SS, et al: Thrombomodulin
domain 1 ameliorates diabetic nephropathy in mice via
anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of
NRF2 antioxidant activity and inhibition of apoptosis.
Diabetologia. 57:424–434. 2014. View Article : Google Scholar
|
15
|
Wang H, Vinnikov I, Shahzad K, Bock F,
Ranjan S, Wolter J, Kashif M, Oh J, Bierhaus A, Nawroth P, et al:
The lectin-like domain of thrombomodulin ameliorates diabetic
glomerulopathy via complement inhibition. Thromb Haemost.
108:1141–1153. 2012. View Article : Google Scholar : PubMed/NCBI
|
16
|
Jayaraman G, Srinivas R, Duggan C,
Ferreira E, Swaminathan S, Somasundaram K, Williams J, Hauser C,
Kurkinen M, Dhar R, et al: p300/cAMP-responsive element-binding
protein interactions with ets-1 and ets-2 in the transcriptional
activation of the human stromelysin promoter. J Biol Chem.
274:17342–17352. 1999. View Article : Google Scholar : PubMed/NCBI
|
17
|
Sheppard KA, Rose DW, Haque ZK, Kurokawa
R, McInerney E, Westin S, Thanos D, Rosenfeld MG, Glass CK and
Collins T: Transcriptional activation by NF-kappaB requires
multiple coactivators. Mol Cell Biol. 19:6367–6378. 1999.
View Article : Google Scholar : PubMed/NCBI
|
18
|
Birrell MA, Catley MC, Hardaker E, Wong S,
Willson TM, McCluskie K, Leonard T, Farrow SN, Collins JL,
Haj-Yahia S and Belvisi MG: Novel role for the liver X nuclear
receptor in the suppression of lung inflammatory responses. J Biol
Chem. 282:31882–31890. 2007. View Article : Google Scholar : PubMed/NCBI
|
19
|
Mogilenko DA, Kudriavtsev IV, Trulioff AS,
Shavva VS, Dizhe EB, Missyul BV, Zhakhov AV, Ischenko AM,
Perevozchikov AP and Orlov SV: Modified low density lipo-protein
stimulates complement C3 expression and secretion via liver X
receptor and Toll-like receptor 4 activation in human macrophages.
J Biol Chem. 287:5954–5968. 2012. View Article : Google Scholar :
|
20
|
Cheng O, Ostrowski RP, Liu W and Zhang JH:
Activation of liver X receptor reduces global ischemic brain injury
by reduction of nuclear factor-kappaB. Neuroscience. 166:1101–1109.
2010. View Article : Google Scholar : PubMed/NCBI
|
21
|
Chen S, Sorrentino R, Shimada K, Bulut Y,
Doherty TM, Crother TR and Arditi M: Chlamydia pneumoniae-induced
foam cell formation requires MyD88-dependent and-independent
signaling and is reciprocally modulated by liver X receptor
activation. J Immunol. 181:7186–7193. 2008. View Article : Google Scholar : PubMed/NCBI
|
22
|
Puddu GM, Cravero E, Arnone G, Muscari A
and Puddu P: Molecular aspects of atherogenesis: New insights and
unsolved questions. J Biomed Sci. 12:839–853. 2005. View Article : Google Scholar : PubMed/NCBI
|
23
|
Wang GX, Hu L, Zhang Z and Liu DP:
Construction of an adenoviral expression vector carrying FLAG and
hrGFP-1 genes and its expression in bone marrow mesenchymal stem
cells. Genet Mol Res. 13:1070–1078. 2014. View Article : Google Scholar : PubMed/NCBI
|
24
|
Luo J, Deng ZL, Luo X, Tang N, Song WX,
Chen J, Sharff KA, Luu HH, Haydon RC, Kinzler KW, et al: A protocol
for rapid generation of recombinant adenoviruses using the AdEasy
system. Nature Protoc. 2:1236–1247. 2007. View Article : Google Scholar
|
25
|
Edmunds RC, McIntyre JK, Luckenbach JA,
Baldwin DH and Incardona P: Toward enhanced MIQE compliance:
Reference residual normalization of qPCR gene expression data. J
Biomol Tech. 25:54–60. 2014.PubMed/NCBI
|
26
|
Khovidhunkit W, Moser AH, Shigenaga JK,
Grunfeld C and Feingold KR: Endotoxin down-regulates ABCG5 and
ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine
macrophages: Differential role of LXR. J Lipid Res. 44:1728–1736.
2003. View Article : Google Scholar : PubMed/NCBI
|
27
|
Stefulj J, Panzenboeck U, Becker T,
Hirschmugl B, Schweinzer C, Lang I, Marsche G, Sadjak A, Lang U,
Desoye G and Wadsack C: Human endothelial cells of the placental
barrier efficiently deliver cholesterol to the fetal circulation
via ABCA1 and ABCG1. Circ Res. 104:600–608. 2009. View Article : Google Scholar : PubMed/NCBI
|
28
|
Ishibashi M, Filomenko R, Rébé C,
Chevriaux A, Varin A, Derangère V, Bessède G, Gambert P, Lagrost L
and Masson D: Knock-down of the oxysterol receptor LXRalpha impairs
cholesterol efflux in human primary macrophages: Lack of
compensation by LXRβ activation. Biochem Pharmacol. 86:122–129.
2013. View Article : Google Scholar : PubMed/NCBI
|
29
|
Repa JJ, Turley SD, Lobaccaro JA, Medina
J, Li L, Lustig K, Shan B, Heyman RA, Dietschy JM and Mangelsdorf
DJ: Regulation of absorption and ABC1-mediated efflux of
cholesterol by RXR heterodimers. Science. 289:1524–1529. 2000.
View Article : Google Scholar : PubMed/NCBI
|
30
|
Wang N, Lan D, Chen W, Matsuura F and Tall
AR: ATP-binding cassette transporters G1 and G4 mediate cellular
cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci
USA. 101:9774–9779. 2004. View Article : Google Scholar : PubMed/NCBI
|
31
|
Feistritzer C and Riewald M: Endothelial
barrier protection by activated protein C through PAR1-dependent
sphin-gosine 1-phosphate receptor-1 crossactivation. Blood.
105:3178–3184. 2005. View Article : Google Scholar : PubMed/NCBI
|
32
|
Matsumoto H, Yamakawa K, Ogura H, Koh T,
Matsumoto N and Shimazu T: Enhanced expression of cell-specific
surface antigens on endothelial microparticles in sepsis-induced
disseminated intravascular coagulation. Shock. 43:443–449. 2015.
View Article : Google Scholar : PubMed/NCBI
|
33
|
Braach N, Frommhold D, Buschmann K, Pflaum
J, Koch L, Hudalla H, Staudacher K, Wang H, Isermann B, Nawroth P
and Poeschl J: RAGE controls activation and anti-inflammatory
signalling of protein C. PloS One. 9:e894222014. View Article : Google Scholar : PubMed/NCBI
|
34
|
Esmon CT: Protein C anticoagulant
system–anti-inflammatory effects. Semin Immunopathol. 34:127–132.
2012. View Article : Google Scholar
|
35
|
Gires O, Kieu C, Fix P, Schmitt B, Münz M,
Wollenberg B and Zeidler R: Tumor necrosis factor alpha negatively
regulates the expression of the carcinoma-associated antigen
epithelial cell adhesion molecule. Cancer. 92:620–628. 2001.
View Article : Google Scholar : PubMed/NCBI
|
36
|
Ravi R, Mookerjee B, van Hensbergen Y,
Bedi GC, Giordano A, El-Deiry WS, Fuchs EJ and Bedi A: p53-mediated
repression of nuclear factor-kappaB RelA via the transcriptional
integrator p300. Cancer Res. 58:4531–4536. 1998.PubMed/NCBI
|
37
|
Wang Y, Li C, Cheng K, Cheng K, Zhang R,
Narsinh K, Li S, Li X, Qin X, Zhang R, Li C, et al: Activation of
liver X receptor improves viability of adipose-derived mesenchymal
stem cells to attenuate myocardial ischemia injury through
TLR4/NF-κB and Keap-1/Nrf-2 signaling pathways. Antioxid Redox
Signal. 21:2543–2557. 2014. View Article : Google Scholar : PubMed/NCBI
|
38
|
Kaur U, Banerjee P, Bir A, Sinha M, Biswas
A and Chakrabarti S: Reactive oxygen species, redox signaling and
neuroinflammation in Alzheimer's disease: The NF-κB connection.
Curr Top Med Chem. 15:446–457. 2015. View Article : Google Scholar
|
39
|
Drdová B and Vachtenheim J: A role for p21
(WAF1) in the cAMP-dependent differentiation of F9 teratocarcinoma
cells into parietal endoderm. Exp Cell Res. 304:293–304. 2005.
View Article : Google Scholar : PubMed/NCBI
|
40
|
Ishii H, Horie S, Kizaki K and Kazama M:
Retinoic acid counteracts both the downregulation of thrombomodulin
and the induction of tissue factor in cultured human endothelial
cells exposed to tumor necrosis factor. Blood. 80:2556–2562.
1992.PubMed/NCBI
|
41
|
Koga S, Morris S, Ogawa S, Liao H,
Bilezikian JP, Chen G, Thompson WJ, Ashikaga T, Brett J, Stern DM,
et al: TNF modulates endothelial properties by decreasing cAMP. Am
J Physiol. 268:C1104–C1113. 1995.PubMed/NCBI
|
42
|
Goligorsky MS, Chen J and Brodsky S:
Workshop: Endothelial cell dysfunction leading to diabetic
nephropathy: Focus on nitric oxide. Hypertension. 37:744–748.
2003.§1. View Article : Google Scholar
|
43
|
Brownlee M: Biochemistry and molecular
cell biology of diabetic complications. Nature. 414:813–820. 2001.
View Article : Google Scholar : PubMed/NCBI
|
44
|
Endemann DH and Schiffrin EL: Endothelial
dysfunction. J Am Soc Nephrol. 15:1983–1992. 2004. View Article : Google Scholar : PubMed/NCBI
|
45
|
Murata I, Takemura G, Asano K, Sano H,
Fujisawa K, Kagawa T, Baba K, Maruyama R, Minatoguchi S, Fujiwara T
and Fujiwara H: Apoptotic cell loss following cell proliferation in
renal glomeruli of Otsuka Long-Evans Tokushima Fatty rats, a model
of human type 2 diabetes. Am J Nephrol. 22:587–595. 2002.
View Article : Google Scholar : PubMed/NCBI
|
46
|
Kumar D, Robertson S and Burns KD:
Evidence of apoptosis in human diabetic kidney. Mol Cell Biochem.
259:67–70. 2004. View Article : Google Scholar : PubMed/NCBI
|
47
|
Baba K, Minatoguchi S, Sano H, Kagawa T,
Murata I, Takemura G, Hirano T, Ohashi H, Takemura M and Fujiwara
T: Involvement of apoptosis in patients with diabetic nephropathy:
A study on plasma soluble Fas levels and pathological findings.
Nephrology (Carlton). 9:94–99. 2004. View Article : Google Scholar
|
48
|
Esmon CT: Inflammation and the activated
protein C anticoagulant pathway. Semin Thromb Hemost. 32(Suppl 1):
49–60. 2006. View Article : Google Scholar : PubMed/NCBI
|
49
|
Borcea V, Morcos M, Isermann B, Henkels M,
Ziegler S, Zumbach M, Amiral J, Längst KD, Seiz W, Ziegler R, et
al: Influence of ramipril on the course of plasma thrombomodulin in
patients with diabetes mellitus. Vasa. 28:172–180. 1999. View Article : Google Scholar : PubMed/NCBI
|
50
|
Fujiwara Y, Tagami S and Kawakami Y:
Circulating thrombomodulin and hematological alterations in type 2
diabetic patients with retinopathy. J Atheroscler Thromb. 5:21–28.
1998. View Article : Google Scholar
|
51
|
Rajashekhar G, Gupta A, Marin A, Friedrich
J, Willuweit A, Berg DT, Cramer MS, Sandusky GE, Sutton TA, Basile
DP, et al: Soluble thrombomodulin reduces inflammation and prevents
microalbuminuria induced by chronic endothelial activation in
transgenic mice. Am J Physiol Renal Physiol. 302:F703–F712. 2012.
View Article : Google Scholar :
|
52
|
Pruna A, Peyri N, Berard M and Boffa MC:
Thrombomodulin is synthesized by human mesangial cells. Kidney Int.
51:687–693. 1997. View Article : Google Scholar : PubMed/NCBI
|
53
|
Rasmussen LM, Schmitz O and Ledet T:
Increased expression of vascular cell adhesion molecule-1 (VCAM-1)
in cultured endothelial cells exposed to serum from type 1 diabetic
patients: No effects of high glucose concentrations. Scand J Clin
Lab Invest. 62:485–493. 2002. View Article : Google Scholar
|
54
|
Janowski BA, Willy PJ, Devi TR, Falck JR
and Mangelsdorf DJ: An oxysterol signalling pathway mediated by the
nuclear receptor LXR alpha. Nature. 383:728–731. 1996. View Article : Google Scholar : PubMed/NCBI
|
55
|
Fiévet C and Staels B: Liver X receptor
modulators: Effects on lipid metabolism and potential use in the
treatment of atherosclerosis. Biochem Pharmacol. 77:1316–1327.
2009. View Article : Google Scholar
|