The role of ultraviolet radiation in the pathogenesis of pterygia (Review)
- Authors:
- Wei‑Ping Zhou
- Yuan‑Fang Zhu
- Bei Zhang
- Wen‑Ya Qiu
- Yu‑Feng Yao
-
Affiliations: Department of Ophthalmology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China - Published online on: May 9, 2016 https://doi.org/10.3892/mmr.2016.5223
- Pages: 3-15
This article is mentioned in:
Abstract
Chui J, Di Girolamo N, Wakefield D and Coroneo MT: The pathogenesis of pterygium: Current concepts and their therapeutic implications. Ocul Surf. 6:24–43. 2008. View Article : Google Scholar : PubMed/NCBI | |
Mackenzie FD, Hirst LW, Battistutta D and Green A: Risk analysis in the development of pterygia. Ophthalmology. 99:1056–1061. 1992. View Article : Google Scholar : PubMed/NCBI | |
Moran DJ and Hollows FC: Pterygium and ultraviolet radiation: A positive correlation. Br J Ophthalmol. 68:343–346. 1984. View Article : Google Scholar : PubMed/NCBI | |
Cameron ME: Pterygium throughout the world. Charles C Thomas; Springfield IL: 1965 | |
Taylor HR, West SK, Rosenthal FS, Munoz B, Newland HS and Emmett EA: Corneal changes associated with chronic UV irradiation. Arch Ophthalmol. 107:1481–1484. 1989. View Article : Google Scholar : PubMed/NCBI | |
Detorakis ET, Sourvinos G and Spandidos DA: Detection of herpes simplex virus and human papilloma virus in ophthalmic pterygium. Cornea. 20:164–167. 2001. View Article : Google Scholar : PubMed/NCBI | |
Gallagher MJ, Giannoudis A, Herrington CS and Hiscott P: Human papillomavirus in pterygium. Br J Ophthalmol. 85:782–784. 2001. View Article : Google Scholar : PubMed/NCBI | |
Chalkia AK, Spandidos DA and Detorakis ET: Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review). Int J Mol Med. 32:539–543. 2013.PubMed/NCBI | |
Anguria P, Kitinya J, Ntuli S and Carmichael T: The role of heredity in pterygium development. Int J Ophthalmol. 7:563–573. 2014.PubMed/NCBI | |
Tsai YY, Bau DT, Chiang CC, Cheng YW, Tseng SH and Tsai FJ: Pterygium and genetic polymorphism of DNA double strand break repair gene Ku70. Mol Vis. 13:1436–1440. 2007.PubMed/NCBI | |
Kau HC, Tsai CC, Hsu WM, Liu JH and Wei YH: Genetic polymorphism of hOGG1 and risk of pterygium in Chinese. Eye (Lond). 18:635–639. 2004. View Article : Google Scholar | |
Pinkerton OD, Hokama Y and Shigemura LA: Immunologic basis for the pathogenesis of pterygium. Am J Ophthalmol. 98:225–228. 1984. View Article : Google Scholar : PubMed/NCBI | |
Hill JC and Maske R: Pathogenesis of pterygium. Eye (Lond). 3:218–226. 1989. View Article : Google Scholar | |
Coroneo MT: Pterygium as an early indicator of ultraviolet insolation: A hypothesis. Br J Ophthalmol. 77:734–739. 1993. View Article : Google Scholar : PubMed/NCBI | |
Nubile M, Curcio C, Lanzini M, Calienno R, Iezzi M, Mastropasqua A, Di Nicola M and Mastropasqua L: Expression of CREB in primary pterygium and correlation with cyclin D1, ki-67, MMP7, p53, p63, Survivin and Vimentin. Ophthalmic Res. 50:99–107. 2013. View Article : Google Scholar : PubMed/NCBI | |
Peng ML, Tsai YY, Chiang CC, Huang YC, Chou MC, Yeh KT, Lee H and Cheng YW: CYP1A1 protein activity is associated with allelic variation in pterygium tissues and cells. Mol Vis. 18:1937–1943. 2012.PubMed/NCBI | |
Tong L, Li J, Chew J, Tan D and Beuerman R: Phospholipase D in the human ocular surface and in pterygium. Cornea. 27:693–698. 2008.PubMed/NCBI | |
Ortak H, Cayli S, Ocakli S and Demir S: Increased expression of aquaporin-1 and aquaporin-3 in pterygium. Cornea. 32:1375–1379. 2013. View Article : Google Scholar : PubMed/NCBI | |
Tan CS, Lim TH, Koh WP, Liew GC, Hoh ST, Tan CC and Au Eong KG: Epidemiology of pterygium on a tropical island in the Riau Archipelago. Eye (Lond). 20:908–912. 2006. View Article : Google Scholar | |
McCarty CA, Fu CL and Taylor HR: Epidemiology of pterygium in Victoria, Australia. Br J Ophthalmol. 84:289–292. 2000. View Article : Google Scholar : PubMed/NCBI | |
Threlfall TJ and English DR: Sun exposure and pterygium of the eye: A dose-response curve. Am J Ophthalmol. 128:280–287. 1999. View Article : Google Scholar : PubMed/NCBI | |
Hilgers JH: Pterygium: Its incidence, heredity and etiology. Am J Ophthalmol. 50:635–644. 1960. View Article : Google Scholar : PubMed/NCBI | |
Di Girolamo N, Chui J, Coroneo MT and Wakefield D: Pathogenesis of pterygia: Role of cytokines, growth factors and matrix metalloproteinases. Prog Retin Eye Res. 23:195–228. 2004. View Article : Google Scholar : PubMed/NCBI | |
Kwok LS and Coroneo MT: A model for pterygium formation. Cornea. 13:219–224. 1994. View Article : Google Scholar : PubMed/NCBI | |
Coroneo MT: Albedo concentration in the anterior eye: A phenomenon that locates some solar diseases. Ophthalmic Surg. 21:60–66. 1990.PubMed/NCBI | |
Coroneo MT, Di Girolamo N and Wakefield D: The pathogenesis of pterygia. Curr Opin Ophthalmol. 10:282–288. 1999. View Article : Google Scholar | |
Anguria P, Carmichael T, Ntuli S and Kitinya J: Chronic inflammatory cells and damaged limbal cells in pterygium. Afr Health Sci. 13:725–730. 2013.PubMed/NCBI | |
Cooper SJ and Bowden GT: Ultraviolet B regulation of transcription factor families: Roles of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in UVB-induced skin carcinogenesis. Curr Cancer Drug Targets. 7:325–334. 2007. View Article : Google Scholar : PubMed/NCBI | |
Yajima H, Lee KJ, Zhang S, Kobayashi J and Chen BP: DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases. J Mol Biol. 385:800–810. 2009. View Article : Google Scholar | |
Heck DE, Vetrano AM, Mariano TM and Laskin JD: UVB light stimulates production of reactive oxygen species: Unexpected role for catalase. J Biol Chem. 278:22432–22436. 2003. View Article : Google Scholar : PubMed/NCBI | |
Fisher GJ and Voorhees JJ: Molecular mechanisms of photoaging and its prevention by retinoic acid: Ultraviolet irradiation induces MAP kinase signal transduction cascades that induce Ap-1-regulated matrix metalloproteinases that degrade human skin in vivo. J Investig Dermatol Symp Proc. 3:61–68. 1998.PubMed/NCBI | |
Dy LC, Pei Y and Travers JB: Augmentation of ultraviolet B radiation-induced tumor necrosis factor production by the epidermal platelet-activating factor receptor. J Biol Chem. 274:26917–26921. 1999. View Article : Google Scholar : PubMed/NCBI | |
Coffer PJ, Burgering BM, Peppelenbosch MP, Bos JL and Kruijer W: UV activation of receptor tyrosine kinase activity. Oncogene. 11:561–569. 1995.PubMed/NCBI | |
Rosette C and Karin M: Ultraviolet light and osmotic stress: Activation of the JNK cascade through multiple growth factor and cytokine receptors. Science. 274:1194–1197. 1996. View Article : Google Scholar : PubMed/NCBI | |
Cimpean AM, Sava MP and Raica M: DNA damage in human pterygium: One-shot multiple targets. Mol Vis. 19:348–356. 2013.PubMed/NCBI | |
Lee DH, Cho HJ, Kim JT, Choi JS and Joo CK: Expression of vascular endothelial growth factor and inducible nitric oxide synthase in pterygia. Cornea. 20:738–742. 2001. View Article : Google Scholar : PubMed/NCBI | |
Kau HC, Tsai CC, Lee CF, Kao SC, Hsu WM, Liu JH and Wei YH: Increased oxidative DNA damage, 8-hydroxydeoxy-guanosine, in human pterygium. Eye (Lond). 20:826–831. 2006. View Article : Google Scholar | |
Tsai YY, Cheng YW, Lee H, Tsai FJ, Tseng SH, Lin CL and Chang KC: Oxidative DNA damage in pterygium. Mol Vis. 11:71–75. 2005.PubMed/NCBI | |
Perra MT, Maxia C, Corbu A, Minerba L, Demurtas P, Colombari R, Murtas D, Bravo S, Piras F and Sirigu P: Oxidative stress in pterygium: Relationship between p53 and 8-hydroxy-deoxyguanosine. Mol Vis. 12:1136–1142. 2006.PubMed/NCBI | |
Klebe S, Callahan T and Power JH: Peroxiredoxin I and II in human eyes: Cellular distribution and association with pterygium and DNA damage. J Histochem Cytochem. 62:85–96. 2014. View Article : Google Scholar : | |
Di Girolamo N, Coroneo M and Wakefield D: Epidermal growth factor receptor signaling is partially responsible for the increased matrix metalloproteinase-1 expression in ocular epithelial cells after UVB radiation. Am J Pathol. 167:489–503. 2005. View Article : Google Scholar : PubMed/NCBI | |
Di Girolamo N, Wakefield D and Coroneo MT: UVB-mediated induction of cytokines and growth factors in pterygium epithelial cells involves cell surface receptors and intracellular signaling. Invest Ophthalmol Vis Sci. 47:2430–2437. 2006. View Article : Google Scholar : PubMed/NCBI | |
Dushku N and Reid TW: Immunohistochemical evidence that human pterygia originate from an invasion of vimentin-expressing altered limbal epithelial basal cells. Curr Eye Res. 13:473–481. 1994. View Article : Google Scholar : PubMed/NCBI | |
Davanger M and Evensen A: Role of the pericorneal papillary structure in renewal of corneal epithelium. Nature. 229:560–561. 1971. View Article : Google Scholar : PubMed/NCBI | |
Tseng SCG CJ, Huang AJW, Kruse FE, Maskin SL and Tsai RJF: Classification of conjunctival surgeries for corneal diseases based on stem cell concept. Ophthalmol Clin North Am. 3:595–610. 1990. | |
Reid TW and Dushku N: What a study of pterygia teaches us about the cornea? Molecular mechanisms of formation. Eye Contact Lens. 36:290–295. 2010. View Article : Google Scholar : PubMed/NCBI | |
Dushku N, John MK, Schultz GS and Reid TW: Pterygia pathogenesis: Corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells. Arch Ophthalmol. 119:695–706. 2001. View Article : Google Scholar : PubMed/NCBI | |
Reid TW and Dushku N: Pterygia and limbal epithelial cells: Relationship and molecular mechanisms. Prog Retin Eye Res. 15(2): 297–329. 1996. View Article : Google Scholar | |
Jaworski CJ, Aryankalayil-John M, Campos MM, Fariss RN, Rowsey J, Agarwalla N, Reid TW, Dushku N, Cox CA, Carper D and Wistow G: Expression analysis of human pterygium shows a predominance of conjunctival and limbal markers and genes associated with cell migration. Mol Vis. 15:2421–2434. 2009.PubMed/NCBI | |
Chui J, Coroneo MT, Tat LT, Crouch R, Wakefield D and Di Girolamo N: Ophthalmic pterygium: A stem cell disorder with premalignant features. Am J Pathol. 178:817–827. 2011. View Article : Google Scholar : PubMed/NCBI | |
Fuchs E: Ueber das Pterygium [Concerning the pterygium]. Graefes Arch Ophthalmol. 38:1–89. 1892.In German. View Article : Google Scholar | |
Hoover HL: Solar ultraviolet irradiation of human cornea, lens and retina: Equations of ocular irradiation. Appl Opt. 25:359–368. 1986. View Article : Google Scholar : PubMed/NCBI | |
Brash DE, Rudolph JA, Simon JA, Lin A, McKenna GJ, Baden HP, Halperin AJ and Pontén J: A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci USA. 88:10124–10128. 1991. View Article : Google Scholar : PubMed/NCBI | |
Kress S, Sutter C, Strickland PT, Mukhtar H, Schweizer J and Schwarz M: Carcinogen-specific mutational pattern in the p53 gene in ultraviolet B radiation-induced squamous cell carcinomas of mouse skin. Cancer Res. 52:6400–6403. 1992.PubMed/NCBI | |
Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE, et al: Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proc Natl Acad Sci USA. 90:4216–4220. 1993. View Article : Google Scholar : PubMed/NCBI | |
Finlay CA, Hinds PW, Tan TH, Eliyahu D, Oren M and Levine AJ: Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol. 8:531–539. 1988. View Article : Google Scholar : PubMed/NCBI | |
Dushku N and Reid TW: P53 expression in altered limbal basal cells of pingueculae, pterygia and limbal tumors. Curr Eye Res. 16:1179–1192. 1997. View Article : Google Scholar | |
Tan DT, Lim AS, Goh HS and Smith DR: Abnormal expression of the p53 tumor suppressor gene in the conjunctiva of patients with pterygium. Am J Ophthalmol. 123:404–405. 1997. View Article : Google Scholar : PubMed/NCBI | |
Weinstein O, Rosenthal G, Zirkin H, Monos T, Lifshitz T and Argov S: Overexpression of p53 tumor suppressor gene in pterygia. Eye (Lond). 16:619–621. 2002. View Article : Google Scholar | |
Ueda Y, Kanazawa S, Kitaoka T, Dake Y, Ohira A, Ouertani AM and Amemiya T: Immunohistochemical study of p53, p21 and PCNA in pterygium. Acta Histochem. 103:159–165. 2001. View Article : Google Scholar : PubMed/NCBI | |
Tsai YY, Cheng YW, Lee H, Tsai FJ, Tseng SH and Chang KC: P53 gene mutation spectrum and the relationship between gene mutation and protein levels in pterygium. Mol Vis. 11:50–55. 2005.PubMed/NCBI | |
Reisman D, McFadden JW and Lu G: Loss of heterozygosity and p53 expression in Pterygium. Cancer Lett. 206:77–83. 2004. View Article : Google Scholar : PubMed/NCBI | |
Shimmura S, Ishioka M, Hanada K, Shimazaki J and Tsubota K: Telomerase activity and p53 expression in pterygia. Invest Ophthalmol Vis Sci. 41:1364–1369. 2000.PubMed/NCBI | |
Chen JK, Tsai RJ and Lin SS: Fibroblasts isolated from human pterygia exhibit transformed cell characteristics. In Vitro Cell Dev Biol Anim. 30A:243–248. 1994. View Article : Google Scholar : PubMed/NCBI | |
Cameron ME: Histology of pterygium: An electron microscopic study. Br J Ophthalmol. 67:604–608. 1983. View Article : Google Scholar : PubMed/NCBI | |
Lemercier G, Cornand G and Burckhart MF: Pinguecula and pterygium: Histologic and electron microscopic study (author's transl). Virchows Arch A Pathol Anat Histol. 379:321–333. 1978.In French. View Article : Google Scholar : PubMed/NCBI | |
Ye J, Song YS, Kang SH, Yao K and Kim JC: Involvement of bone marrow-derived stem and progenitor cells in the pathogenesis of pterygium. Eye (Lond). 18:839–843. 2004. View Article : Google Scholar | |
Touhami A, Di Pascuale MA, Kawatika T, Del Valle M, Rosa RH Jr, Dubovy S and Tseng SC: Characterisation of myofibroblasts in fibrovascular tissues of primary and recurrent pterygia. Br J Ophthalmol. 89:269–274. 2005. View Article : Google Scholar : PubMed/NCBI | |
Kato N, Shimmura S, Kawakita T, Miyashita H, Ogawa Y, Yoshida S, Higa K, Okano H and Tsubota K: Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium. Invest Ophthalmol Vis Sci. 48:1511–1517. 2007. View Article : Google Scholar : PubMed/NCBI | |
Maloof AJ, Ho A and Coroneo MT: Influence of corneal shape on limbal light focusing. Invest Ophthalmol Vis Sci. 35:2592–2598. 1994.PubMed/NCBI | |
Butrus SI, Ashraf MF, Laby DM, Rabinowitz AI, Tabbara SO and Hidayat AA: Increased numbers of mast cells in pterygia. Am J Ophthalmol. 119:236–237. 1995. View Article : Google Scholar : PubMed/NCBI | |
Ratnakar KS, Goswamy V and Agarwal LP: Mast cells and pterygium. Acta Ophthalmol (Copenh). 54:363–368. 1976. View Article : Google Scholar | |
Golu T, Mogoantă L, Streba CT, Pirici DN, Mălăescu D, Mateescu GO and Mutiu G: Pterygium: Histological and immunohistochemical aspects. Rom J Morphol Embryol. 52:153–158. 2011.PubMed/NCBI | |
Wen Z and Liu Z: The abnormal expression of interleukine-1 family in pterygium. Yan Ke Xue Bao. 19:133–136. 2003.PubMed/NCBI | |
Di Girolamo N, Kumar RK, Coroneo MT and Wakefield D: UVB-mediated induction of interleukin-6 and -8 in pterygia and cultured human pterygium epithelial cells. Invest Ophthalmol Vis Sci. 43:3430–3437. 2002.PubMed/NCBI | |
Kria L, Ohira A and Amemiya T: Immunohistochemical localization of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor-beta and tumor necrosis factor-alpha in the pterygium. Acta Histochem. 98:195–201. 1996. View Article : Google Scholar : PubMed/NCBI | |
Kennedy M, Kim KH, Harten B, Brown J, Planck S, Meshul C, Edelhauser H, Rosenbaum JT, Armstrong CA and Ansel JC: Ultraviolet irradiation induces the production of multiple cytokines by human corneal cells. Invest Ophthalmol Vis Sci. 38:2483–2491. 1997.PubMed/NCBI | |
Krämer M, Sachsenmaier C, Herrlich P and Rahmsdorf HJ: UV irradiation-induced interleukin-1 and basic fibroblast growth factor synthesis and release mediate part of the UV response. J Biol Chem. 268:6734–6741. 1993.PubMed/NCBI | |
Bazzoni F, Kruys V, Shakhov A, Jongeneel CV and Beutler B: Analysis of tumor necrosis factor promoter responses to ultraviolet light. J Clin Invest. 93:56–62. 1994. View Article : Google Scholar : PubMed/NCBI | |
Devary Y, Rosette C, DiDonato JA and Karin M: NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. Science. 261:1442–1445. 1993. View Article : Google Scholar : PubMed/NCBI | |
Siak JJ, Ng SL, Seet LF, Beuerman RW and Tong L: The nuclear-factor kappaB pathway is activated in pterygium. Invest Ophthalmol Vis Sci. 52:230–236. 2011. View Article : Google Scholar | |
Cubitt CL, Tang Q, Monteiro CA, Lausch RN and Oakes JE: IL-8 gene expression in cultures of human corneal epithelial cells and keratocytes. Invest Ophthalmol Vis Sci. 34:3199–3206. 1993.PubMed/NCBI | |
Cubitt CL, Lausch RN and Oakes JE: Differences in interleukin-6 gene expression between cultured human corneal epithelial cells and keratocytes. Invest Ophthalmol Vis Sci. 36:330–336. 1995.PubMed/NCBI | |
Hong JW, Liu JJ, Lee JS, Mohan RR, Mohan RR, Woods DJ, He YG and Wilson SE: Proinflammatory chemokine induction in keratocytes and inflammatory cell infiltration into the cornea. Invest Ophthalmol Vis Sci. 42:2795–2803. 2001.PubMed/NCBI | |
Di Girolamo N, McCluskey P, Lloyd A, Coroneo MT and Wakefield D: Expression of MMPs and TIMPs in human pterygia and cultured pterygium epithelial cells. Invest Ophthalmol Vis Sci. 41:671–679. 2000.PubMed/NCBI | |
Fenton RR, Molesworth-Kenyon S, Oakes JE and Lausch RN: Linkage of IL-6 with neutrophil chemoattractant expression in virus-induced ocular inflammation. Invest Ophthalmol Vis Sci. 43:737–743. 2002.PubMed/NCBI | |
Cohen T, Nahari D, Cerem LW, Neufeld G and Levi BZ: Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem. 271:736–741. 1996. View Article : Google Scholar : PubMed/NCBI | |
Bacon KB and Camp RD: Interleukin (IL) -8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C. Biochem Biophys Res Commun. 169:1099–1104. 1990. View Article : Google Scholar : PubMed/NCBI | |
Roebuck KA: Regulation of interleukin-8 gene expression. J Interferon Cytokine Res. 19:429–438. 1999. View Article : Google Scholar : PubMed/NCBI | |
Strieter RM, Kunkel SL, Elner VM, Martonyi CL, Koch AE, Polverini PJ and Elner SG: Interleukin-8. A corneal factor that induces neovascularization. Am J Pathol. 141:1279–1284. 1992.PubMed/NCBI | |
Starcher B: Role for tumour necrosis factor-alpha receptors in ultraviolet-induced skin tumours. Br J Dermatol. 142:1140–1147. 2000. View Article : Google Scholar : PubMed/NCBI | |
Yoshida S, Ono M, Shono T, Izumi H, Ishibashi T, Suzuki H and Kuwano M: Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol Cell Biol. 17:4015–4023. 1997. View Article : Google Scholar : PubMed/NCBI | |
Menzel EJ, Egerer I, Kulnig W and Smolen JS: Electron-microscopic and biochemical characteristics of pterygia (author's transl). Klin Monbl Augenheilkd. 179:438–441. 1981.In German. View Article : Google Scholar : PubMed/NCBI | |
Dake Y, Mukae R, Soda Y, Kaneko M and Amemiya T: Immunohistochemical localization of collagen types I, II, III and IV in pterygium tissues. Acta Histochem. 87:71–74. 1989. View Article : Google Scholar | |
Nolan TM, Di Girolamo N, Sachdev NH, Hampartzoumian T, Coroneo MT and Wakefield D: The role of ultraviolet irradiation and heparin-binding epidermal growth factor-like growth factor in the pathogenesis of pterygium. Am J Pathol. 162:567–574. 2003. View Article : Google Scholar : PubMed/NCBI | |
Bianchi E, Scarinci F, Grande C, Plateroti R, Plateroti P, Plateroti AM, Fumagalli L, Capozzi P, Feher J and Artico M: Immunohistochemical profile of VEGF, TGF-β and PGE2 in human pterygium and normal conjunctiva: Experimental study and review of the literature. Int J Immunopathol Pharmacol. 25:607–615. 2012.PubMed/NCBI | |
Liu Z, Xie Y and Zhang M: Overexpression of type I growth factor receptors in pterygium. Chin Med J (Engl). 115:418–421. 2002. | |
Detorakis ET and Spandidos DA: Pathogenetic mechanisms and treatment options for ophthalmic pterygium: Trends and perspectives (Review). Int J Mol Med. 23:439–447. 2009. View Article : Google Scholar : PubMed/NCBI | |
Krial L, Ohira A and Amemiya T: Growth factors in cultured pterygium fibroblasts: Immunohistochemical and ELISA analysis. Graefes Arch Clin Exp Ophthalmol. 236:702–708. 1998. View Article : Google Scholar | |
Li Y, Bi Z, Yan B and Wan Y: UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway. Int J Mol Med. 18:713–719. 2006.PubMed/NCBI | |
Kim H, Kang JS and Lee WJ: The production IL-21 and VEGF in UVB-irradiated human keratinocyte cell line, HaCaT. Immune Netw. 10:75–80. 2010. View Article : Google Scholar : PubMed/NCBI | |
Brauchle M, Funk JO, Kind P and Werner S: Ultraviolet B and H2O2 are potent inducers of vascular endothelial growth factor expression in cultured keratinocytes. J Biol Chem. 271:21793–21797. 1996. View Article : Google Scholar : PubMed/NCBI | |
Ley RD, Miska KB and Kusewitt DF: Photoreactivation of ultraviolet radiation-induced basic fibroblast growth factor (bFGF) and the role of bFGF in corneal lesion formation in Monodelphis domestica. Environ Mol Mutagen. 38:175–179. 2001. View Article : Google Scholar : PubMed/NCBI | |
Brenner M, Degitz K, Besch R and Berking C: Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation. Br J Dermatol. 153:733–739. 2005. View Article : Google Scholar : PubMed/NCBI | |
Quan T, He T, Kang S, Voorhees JJ and Fisher GJ: Ultraviolet irradiation alters transforming growth factor beta/smad pathway in human skin in vivo. J Invest Dermatol. 119:499–506. 2002. View Article : Google Scholar : PubMed/NCBI | |
Xu D, Yuan R, Gu H, Liu T, Tu Y, Yang Z and He L: The effect of ultraviolet radiation on the transforming growth factor beta 1/Smads pathway and p53 in actinic keratosis and normal skin. Arch Dermatol Res. 305:777–786. 2013. View Article : Google Scholar : PubMed/NCBI | |
Abramovitch R, Neeman M, Reich R, Stein I, Keshet E, Abraham J, Solomon A and Marikovsky M: Intercellular communication between vascular smooth muscle and endothelial cells mediated by heparin-binding epidermal growth factor-like growth factor and vascular endothelial growth factor. FEBS Lett. 425:441–447. 1998. View Article : Google Scholar : PubMed/NCBI | |
Harding PA, Davis-Fleischer KM, Crissman-Combs MA, Miller MT, Brigstock DR and Besner GE: Induction of anchorage independent growth by heparin-binding EGF-like growth factor (HB-EGF). Growth Factors. 17:49–61. 1999. View Article : Google Scholar : PubMed/NCBI | |
Nolan TM, Di Girolamo N, Coroneo MT and Wakefield D: Proliferative effects of heparin-binding epidermal growth factor-like growth factor on pterygium epithelial cells and fibroblasts. Invest Ophthalmol Vis Sci. 45:110–113. 2004. View Article : Google Scholar | |
Witmer AN, Vrensen GF, Van Noorden CJ and Schlingemann RO: Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res. 22:1–29. 2003. View Article : Google Scholar : PubMed/NCBI | |
Andresen JL and Ehlers N: Chemotaxis of human keratocytes is increased by platelet-derived growth factor-BB, epidermal growth factor, transforming growth factor-alpha, acidic fibroblast growth factor, insulin-like growth factor-I, and transforming growth factor-beta. Curr Eye Res. 17:79–87. 1998. View Article : Google Scholar : PubMed/NCBI | |
Fredj-Reygrobellet D, Plouet J, Delayre T, Baudouin C, Bourret F and Lapalus P: Effects of aFGF and bFGF on wound healing in rabbit corneas. Curr Eye Res. 6:1205–1209. 1987. View Article : Google Scholar : PubMed/NCBI | |
Nugent MA and Iozzo RV: Fibroblast growth factor-2. Int J Biochem Cell Biol. 32:115–120. 2000. View Article : Google Scholar : PubMed/NCBI | |
Govinden R and Bhoola KD: Genealogy, expression, and cellular function of transforming growth factor-beta. Pharmacol Ther. 98:257–265. 2003. View Article : Google Scholar : PubMed/NCBI | |
Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH, et al: Transforming growth factor type beta: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA. 83:4167–4171. 1986. View Article : Google Scholar : PubMed/NCBI | |
Verrecchia F and Mauviel A: Transforming growth factor-beta and fibrosis. World J Gastroenterol. 13:3056–3062. 2007.PubMed/NCBI | |
Dushku N and Reid TW: Immunohistochemical evidence that pterygia originate from Rb and TGF-beta expressing, p53 transformed, limbal basal stem cells. Invest Ophthalmol Vis Sci. 36:S10271995. | |
Oikawa T, Onozawa C, Sakaguchi M, Morita I and Murota S: Three isoforms of platelet-derived growth factors all have the capability to induce angiogenesis in vivo. Biol Pharm Bull. 17:1686–1688. 1994. View Article : Google Scholar : PubMed/NCBI | |
Kamiyama K, Iguchi I, Wang X and Imanishi J: Effects of PDGF on the migration of rabbit corneal fibroblasts and epithelial cells. Cornea. 17:315–325. 1998. View Article : Google Scholar : PubMed/NCBI | |
Aspiotis M, Tsanou E, Gorezis S, Ioachim E, Skyrlas A, Stefaniotou M and Malamou-Mitsi V: Angiogenesis in pterygium: Study of microvessel density, vascular endothelial growth factor, and thrombospondin-1. Eye (Lond). 21:1095–1101. 2007. View Article : Google Scholar | |
Chui J, Di Girolamo N, Coroneo MT and Wakefield D: The role of substance P in the pathogenesis of pterygia. Invest Ophthalmol Vis Sci. 48:4482–4489. 2007. View Article : Google Scholar : PubMed/NCBI | |
Naib-Majani W, Breipohl W, Shazli EE, Theuerkauf I, Pleyer U, Hahne JC and Wernert N: The Ets-1 transcription factor is involved in pterygial angiogenesis. Anat Histol Embryol. 36:107–110. 2007. View Article : Google Scholar : PubMed/NCBI | |
Lee JK, Song YS, Ha HS, Park JH, Kim MK, Park AJ and Kim JC: Endothelial progenitor cells in pterygium pathogenesis. Eye (Lond). 21:1186–1193. 2007. View Article : Google Scholar | |
Tran MT, Lausch RN and Oakes JE: Substance P differentially stimulates IL-8 synthesis in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 41:3871–3877. 2000.PubMed/NCBI | |
Jin J, Guan M, Sima J, Gao G, Zhang M, Liu Z, Fant J and Ma JX: Decreased pigment epithelium-derived factor and increased vascular endothelial growth factor levels in pterygia. Cornea. 22:473–477. 2003. View Article : Google Scholar : PubMed/NCBI | |
Legat FJ, Griesbacher T, Schicho R, Althuber P, Schuligoi R, Kerl H and Wolf P: Repeated subinflammatory ultraviolet B irradiation increases substance P and calcitonin gene-related peptide content and augments mustard oil-induced neurogenic inflammation in the skin of rats. Neurosci Lett. 329:309–313. 2002. View Article : Google Scholar : PubMed/NCBI | |
Tsai YY, Chiang CC, Yeh KT, Lee H and Cheng YW: Effect of TIMP-1 and MMP in pterygium invasion. Invest Ophthalmol Vis Sci. 51:3462–3467. 2010. View Article : Google Scholar : PubMed/NCBI | |
Zeng J, Jiang D, Liu X and Tang L: Expression of matrix metal-loproteinase in human pterygia. Yan Ke Xue Bao. 20:242–245. 2004.In Chinese. | |
Ansari MW, Rahi AH and Shukla BR: Pseudoelastic nature of pterygium. Br J Ophthalmol. 54:473–476. 1970. View Article : Google Scholar : PubMed/NCBI | |
Hogan MJ and Alvarado J: Pterygium and pinguecula: Electron microscopic study. Arch Ophthalmol. 78:174–186. 1967. View Article : Google Scholar : PubMed/NCBI | |
Austin P, Jakobiec FA and Iwamoto T: Elastodysplasia and elastodystrophy as the pathologic bases of ocular pterygia and pinguecula. Ophthalmology. 90:96–109. 1983. View Article : Google Scholar : PubMed/NCBI | |
Bernstein EF, Chen YQ, Tamai K, Shepley KJ, Resnik KS, Zhang H, Tuan R, Mauviel A and Uitto J: Enhanced elastin and fibrillin gene expression in chronically photodamaged skin. J Invest Dermatol. 103:182–186. 1994. View Article : Google Scholar : PubMed/NCBI | |
Bernstein EF, Brown DB, Urbach F, Forbes D, Del Monaco M, Wu M, Katchman SD and Uitto J: Ultraviolet radiation activates the human elastin promoter in transgenic mice: A novel in vivo and in vitro model of cutaneous photoaging. J Invest Dermatol. 105:269–273. 1995. View Article : Google Scholar : PubMed/NCBI | |
Schwartz E, Feinberg E, Lebwohl M, Mariani TJ and Boyd CD: Ultraviolet radiation increases tropoelastin accumulation by a post-transcriptional mechanism in dermal fibroblasts. J Invest Dermatol. 105:65–69. 1995. View Article : Google Scholar : PubMed/NCBI | |
Wang IJ, Hu FR, Chen PJ and Lin CT: Mechanism of abnormal elastin gene expression in the pinguecular part of pterygia. Am J Pathol. 157:1269–1276. 2000. View Article : Google Scholar : PubMed/NCBI | |
Di Girolamo N, Wakefield D and Coroneo MT: Differential expression of matrix metalloproteinases and their tissue inhibitors at the advancing pterygium head. Invest Ophthalmol Vis Sci. 41:4142–4149. 2000.PubMed/NCBI | |
Naib-Majani W, Eltohami I, Wernert N, Watts W, Tschesche H, Pleyer U and Breipohl W: Distribution of extracellular matrix proteins in pterygia: An immunohistochemical study. Graefes Arch Clin Exp Ophthalmol. 242:332–338. 2004. View Article : Google Scholar : PubMed/NCBI | |
Sekhon BS: Matrix metalloproteinases - an overview. Res Rep Biol. 1:1–20. 2010. | |
Li DQ, Lee SB, Gunja-Smith Z, Liu Y, Solomon A, Meller D and Tseng SC: Overexpression of collagenase (MMP-1) and stromelysin (MMP-3) by pterygium head fibroblasts. Arch Ophthalmol. 119:71–80. 2001.PubMed/NCBI | |
Di Girolamo N, Coroneo MT and Wakefield D: Active matrilysin (MMP-7) in human pterygia: Potential role in angiogenesis. Invest Ophthalmol Vis Sci. 42:1963–1968. 2001.PubMed/NCBI | |
Yang SF, Lin CY, Yang PY, Chao SC, Ye YZ and Hu DN: Increased expression of gelatinase (MMP-2 and MMP-9) in pterygia and pterygium fibroblasts with disease progression and activation of protein kinase C. Invest Ophthalmol Vis Sci. 50:4588–4596. 2009. View Article : Google Scholar : PubMed/NCBI | |
Koźák I, Klisenbauer D and Juhás T: UV-B induced production of MMP-2 and MMP-9 in human corneal cells. Physiol Res. 52:229–234. 2003. | |
Ramos MC, Steinbrenner H, Stuhlmann D, Sies H and Brenneisen P: Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation. Biol Chem. 385:75–86. 2004. View Article : Google Scholar : PubMed/NCBI | |
Brenneisen P, Sies H and Scharffetter-Kochanek K: Ultraviolet-B irradiation and matrix metalloproteinases: From induction via signaling to initial events. Ann N Y Acad Sci. 973:31–43. 2002. View Article : Google Scholar : PubMed/NCBI | |
Stein B, Rahmsdorf HJ, Steffen A, Litfin M and Herrlich P: UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol Cell Biol. 9:5169–5181. 1989. View Article : Google Scholar : PubMed/NCBI | |
Rittié L and Fisher GJ: UV-light-induced signal cascades and skin aging. Ageing Res Rev. 1:705–720. 2002. View Article : Google Scholar : PubMed/NCBI | |
Di Girolamo N, Coroneo MT and Wakefield D: UVB-elicited induction of MMP-1 expression in human ocular surface epithelial cells is mediated through the ERK1/2 MAPK-dependent pathway. Invest Ophthalmol Vis Sci. 44:4705–4714. 2003. View Article : Google Scholar : PubMed/NCBI | |
Bachelor MA and Bowden GT: UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. Semin Cancer Biol. 14:131–138. 2004. View Article : Google Scholar : PubMed/NCBI | |
Chao SC, Hu DN, Yang PY, Lin CY, Nien CW, Yang SF and Robert JE: Ultraviolet-A irradiation upregulated urokinase-type plasminogen activator in pterygium fibroblasts through ERK and JNK pathways. Invest Ophthalmol Vis Sci. 54:999–1007. 2013. View Article : Google Scholar : PubMed/NCBI | |
Ooi JL, Sharma NS, Papalkar D, Sharma S, Oakey M, Dawes P and Coroneo MT: Ultraviolet fluorescence photography to detect early sun damage in the eyes of school-aged children. Am J Ophthalmol. 141:294–298. 2006. View Article : Google Scholar : PubMed/NCBI | |
Tan DT, Tang WY, Liu YP, Goh HS and Smith DR: Apoptosis and apoptosis related gene expression in normal conjunctiva and pterygium. Br J Ophthalmol. 84:212–226. 2000. View Article : Google Scholar : PubMed/NCBI | |
Kwok LS, Kuznetsov VA, Ho A and Coroneo MT: Prevention of the adverse photic effects of peripheral light-focusing using UV-blocking contact lenses. Invest Ophthalmol Vis Sci. 44:1501–1507. 2003. View Article : Google Scholar : PubMed/NCBI | |
Coroneo M: Ultraviolet radiation and the anterior eye. Eye Contact Lens. 37:214–224. 2011. View Article : Google Scholar : PubMed/NCBI | |
Said DG, Faraj LA, Elalfy MS, Yeung A, Miri A, Fares U, Otri AM, Rahman I, Maharajan S and Dua HS: Intra-lesional 5 fluorouracil for the management of recurrent pterygium. Eye (Lond). 27:1123–1129. 2013. View Article : Google Scholar | |
Cuevas P, Outeiriño LA, Angulo J and Giménez-Gallego G: Topical dobesilate eye drops for ophthalmic primary pterygium. BMJ Case Rep. 2012. View Article : Google Scholar | |
Lee K, Young Lee S, Park SY and Yang H: Antifibrotic effect of pirfenidone on human pterygium fibroblasts. Curr Eye Res. 39:680–685. 2014. View Article : Google Scholar : PubMed/NCBI | |
Sarac O, Demirel S and Oltulu R: Efficacy of intralesional bevacizumab administration in primary pterygium: A quantitative analysis. Eye Contact Lens. 40:46–50. 2014. View Article : Google Scholar |