Identification and characteristics of the testes-specific gene, Ccdc38, in mice

  • Authors:
    • Shou‑Ren Lin
    • Yu‑Chi Li
    • Man‑Ling Luo
    • Huan Guo
    • Tian‑Tian Wang
    • Jian‑Bo Chen
    • Qian Ma
    • Yan‑Li Gu
    • Zhi‑Mao Jiang
    • Yao‑Ting Gui
  • View Affiliations

  • Published online on: June 3, 2016     https://doi.org/10.3892/mmr.2016.5360
  • Pages: 1290-1296
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Abstract

Distinguishing the testes-specific genes in different species may disclose key genes associated with testes-specific functions and provide sufficient information for the study and treatment of male infertility. A testes‑specific gene, coiled-coil domain containing 38 (Ccdc38), was identified by screening UniGene libraries. Systematic bioinformatics analysis demonstrated that the CCDC38 protein was conserved in various mammalian species. It was determined that CCDC38 was exclusively expressed in testes and its expression increased from 2‑8 weeks of age. Additional immunohistochemical analysis indicated that CCDC38 was mainly expressed in spermatogonia and spermatocytes. It is of note that, immunofluorescence and co-immunoprecipitation assays demonstrated that CCDC38 interacted with ubiquitinated histone H2A in mouse testes. Therefore, these results suggest that Ccdc38 is a testes-specific gene, which may be important for mouse spermatogenesis.
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August-2016
Volume 14 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Lin SR, Li YC, Luo ML, Guo H, Wang TT, Chen JB, Ma Q, Gu YL, Jiang ZM, Gui YT, Gui YT, et al: Identification and characteristics of the testes-specific gene, Ccdc38, in mice. Mol Med Rep 14: 1290-1296, 2016.
APA
Lin, S., Li, Y., Luo, M., Guo, H., Wang, T., Chen, J. ... Gui, Y. (2016). Identification and characteristics of the testes-specific gene, Ccdc38, in mice. Molecular Medicine Reports, 14, 1290-1296. https://doi.org/10.3892/mmr.2016.5360
MLA
Lin, S., Li, Y., Luo, M., Guo, H., Wang, T., Chen, J., Ma, Q., Gu, Y., Jiang, Z., Gui, Y."Identification and characteristics of the testes-specific gene, Ccdc38, in mice". Molecular Medicine Reports 14.2 (2016): 1290-1296.
Chicago
Lin, S., Li, Y., Luo, M., Guo, H., Wang, T., Chen, J., Ma, Q., Gu, Y., Jiang, Z., Gui, Y."Identification and characteristics of the testes-specific gene, Ccdc38, in mice". Molecular Medicine Reports 14, no. 2 (2016): 1290-1296. https://doi.org/10.3892/mmr.2016.5360