Open Access

Overexpression of Dlx2 leads to postnatal condyle degradation

  • Authors:
    • Jiewen Dai
    • Jiawen Si
    • Xiaofang Zhu
    • Lei Zhang
    • Dandan Wu
    • Jingting Lu
    • Ningjuan Ouyang
    • Xudong Wang
    • Guofang Shen
  • View Affiliations

  • Published online on: June 17, 2016     https://doi.org/10.3892/mmr.2016.5406
  • Pages: 1624-1630
  • Copyright: © Dai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Distal-less homeobox 2 (Dlx2), a member of the Dlx family of transcription factors, is important for the development of craniofacial tissues. Previous studies based on knock‑out mutant mice revealed that Dlx2 primarily disturbed the development of tissues from maxillary arch. The present study used a transgenic mouse model to specifically overexpress Dlx2 in neural crest cells in order to investigate the role of Dlx2 overexpression in post‑natal condyle in mice. The model was constructed and the phenotype observed using gross observation, micro‑CT scan and histological examination. The model determined that overexpression of Dlx2 may lead to postnatal condyle malformation, subchondral bone degradation and irregular histological structure of the condylar cartilage. In addition, the expression of osteocalcin in the condyle region was markedly downregulated, whereas expression of msh homeobox 2 was upregulated. The results of the present study suggest that Dlx2 overexpression in cranial neural crest cells would disrupt the development of post‑natal condyle, which demonstrates that the expression level and the spatiotemporal expression patterns of Dlx2 may be important in regulating the development of post-natal condyle in mice, and also offered a possible temporal‑mandibular joint osteoarthritis model animal for future studies.
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August-2016
Volume 14 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Dai J, Si J, Zhu X, Zhang L, Wu D, Lu J, Ouyang N, Wang X and Shen G: Overexpression of Dlx2 leads to postnatal condyle degradation. Mol Med Rep 14: 1624-1630, 2016.
APA
Dai, J., Si, J., Zhu, X., Zhang, L., Wu, D., Lu, J. ... Shen, G. (2016). Overexpression of Dlx2 leads to postnatal condyle degradation. Molecular Medicine Reports, 14, 1624-1630. https://doi.org/10.3892/mmr.2016.5406
MLA
Dai, J., Si, J., Zhu, X., Zhang, L., Wu, D., Lu, J., Ouyang, N., Wang, X., Shen, G."Overexpression of Dlx2 leads to postnatal condyle degradation". Molecular Medicine Reports 14.2 (2016): 1624-1630.
Chicago
Dai, J., Si, J., Zhu, X., Zhang, L., Wu, D., Lu, J., Ouyang, N., Wang, X., Shen, G."Overexpression of Dlx2 leads to postnatal condyle degradation". Molecular Medicine Reports 14, no. 2 (2016): 1624-1630. https://doi.org/10.3892/mmr.2016.5406