Transforming growth factor-β1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway Corrigendum in /10.3892/mmr.2022.12621

Yue,Xue‑Jing; Guo,Yan; Yang,Hai‑Jie; Feng,Zhi‑Wei; Li,Tong; Xu,Yu‑Ming

doi:10.3892/mmr.2016.5411

Transforming growth factor-β1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway

Corrigendum in: /10.3892/mmr.2022.12621

Authors:
- Xue‑Jing Yue
- Yan Guo
- Hai‑Jie Yang
- Zhi‑Wei Feng
- Tong Li
- Yu‑Ming Xu
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Affiliations: Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China, Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, P.R. China, College of Life Science and Technology, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China
Published online on: June 17, 2016 https://doi.org/10.3892/mmr.2016.5411
Pages: 1709-1713

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Abstract

Leptomeningeal fibrosis is important in the pathogenesis of communicating hydrocephalus following subarachnoid hemorrhage; however, the underlying mechanisms of leptomeningeal fibrosis remain largely unclear. In the present study, primary meningeal mesothelial cells (MMCs) were used as a cell model to investigate the effect of transforming growth factor‑β1 (TGF‑β1) on leptomeningeal fibrosis. Firstly, primary MMCs were isolated from rat brains and characterized by immunofluorescene, staining positive for keratin and vimentin, but negative for factor VIII. Upon TGF‑β1 treatment, MMCs were induced to express connective tissue growth factor (CTGF), an indicator of fibrosis, in a dose‑dependent manner. Furthermore, p38 mitogen‑activated protein kinase (MAPK) signaling was significantly activated by TGF‑β1. However, in the presence of a p38 MAPK inhibitor, TGF‑β1‑induced CTGF expression was markedly suppressed. Together, these data suggest that TGF‑β1 could induce fibrosis of MMCs via the p38 MAPK signaling pathway, providing a novel potential target for intervention in TGF‑β1‑induced leptomeningeal fibrosis.

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