Occupational exposure to pesticides as a possible risk factor for the development of chronic diseases in humans (Review)
- Authors:
- Silvia Gangemi
- Edoardo Miozzi
- Michele Teodoro
- Giusi Briguglio
- Annamaria De Luca
- Carmela Alibrando
- Irene Polito
- Massimo Libra
-
Affiliations: Department of Biomedical, Odontoiatric, Morphological and Functional Images, Occupational Medicine Section, ‘Policlinico G. Martino’ Hospital, University of Messina, I‑98125 Messina, Italy, Department of Biomedical and Biotechnological Sciences, Laboratory of Translational Oncology and Functional Genomics, Section of General and Clinical Pathology and Oncology, University of Catania, I‑95124 Catania, Italy - Published online on: October 10, 2016 https://doi.org/10.3892/mmr.2016.5817
- Pages: 4475-4488
-
Copyright: © Gangemi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Valentino M, Rapisarda V and Fenga C: Hand injuries due to high-pressure injection devices for painting in shipyards: Circumstances, management, and outcome in twelve patients. Am J Ind Med. 43:539–542. 2003. View Article : Google Scholar : PubMed/NCBI | |
Rapisarda V, Valentino M, Bolognini S and Fenga C: Noise-related occupational risk aboard fishing vessels: Considerations on prevention and the protection of exposed workers. G Ital Med Lav Ergon. 26:191–196. 2004.(In Italian). PubMed/NCBI | |
Costa C, Ozcagli E, Gangemi S, Schembri F, Giambò F, Androutsopoulos V, Tsatsakis A and Fenga C: Molecular biomarkers of oxidative stress and role of dietary factors in gasoline station attendants. Food Chem Toxicol. 90:30–35. 2016. View Article : Google Scholar : PubMed/NCBI | |
Valentino M, Rapisarda V, Scalise L, Paone N, Santarelli L, Fenga C and Rossi GL: A new method for the experimental assessment of finger haemodynamic effects induced by a hydraulic breaker in operative conditions. J Occup Health. 46:253–259. 2004. View Article : Google Scholar : PubMed/NCBI | |
Rapisarda V, Valentino M, Ravalli P, Fenga C and Duscio D: Occupational brucellosis in slaughtering of sheep and goats: Study of five cases from a municipal abattoir in south-eastern Sicily. Med Lav. 96:134–141. 2005.(In Italian). PubMed/NCBI | |
Fenga C, Rapisarda V, Valentino M, Cacciola A, Deboli R, Calvo A and Germanò D: Hand-arm vibration syndrome and upper limbs diseases in the forest workers of Italia meridionale. G Ital Med Lav Ergon. 29:(Suppl 3). 592–593. 2007.(In Italian). PubMed/NCBI | |
Fenga C, Cacciola A, Di Nola C, Calimeri S, Lo Giudice D, Pugliese M, Niutta PP and Martino LB: Serologic investigation of the prevalence of Chlamydophila psittaci in occupationally-exposed subjects in eastern Sicily. Ann Agric Environ Med. 14:93–96. 2007.PubMed/NCBI | |
Fenga C, Di Pietro R, Fenga P, Di Nola C, Spinella R, Cacciola A, Germanò D and Aragona P: Asthenopia in VDT users: Our experience. G Ital Med Lav Ergon. 29:(Suppl 3). 500–501. 2007.(In Italian). PubMed/NCBI | |
Fenga C, Platania CA, Di Rosa A, Alibrandi A, De Luca A, Barresi G, Di Nola C and Cacciola A: Mobbing: Between personality traits and organizational-managerial characteristics of the occupational environment. G Ital Med Lav Ergon. 34:(Suppl 1A). A11–A16. 2012.(In Italian). PubMed/NCBI | |
Fenga C and Pugliese M: Endemic zoonosis in Mediterranean area. G Ital Med Lav Ergon. 35:347–349. 2013.(In Italian). PubMed/NCBI | |
Fenga C, Aragona P, Di Nola C and Spinella R: Comparison of ocular surface disease index and tear osmolarity as markers of ocular surface dysfunction in video terminal display workers. Am J Ophthalmol. 158:41–48.e2. 2014. View Article : Google Scholar : PubMed/NCBI | |
Fenga C, Gangemi S, De Luca A, Calimeri S, Lo Giudice D, Pugliese M, Licitra F, Alibrandi A and Costa C: Seroprevalence and occupational risk survey for Coxiella burnetii among exposed workers in Sicily, Southern Italy. Int J Occup Med Environ Health. 28:901–907. 2015.PubMed/NCBI | |
Rapisarda V, Ledda C, Ferrante M, Fiore M, Cocuzza S, Bracci M and Fenga C: Blood pressure and occupational exposure to noise and lead (Pb): A cross-sectional study. Toxicol Ind Health. 32:1729–1736. 2016. View Article : Google Scholar : PubMed/NCBI | |
Fenga C: Occupational exposure and risk of breast cancer. Biomed Rep. 4:282–292. 2016.PubMed/NCBI | |
Fenga C, Cacciola A, Rapisarda V, Spatari G, Calimeri S, Minciullo PL, Di Pasquale G and Gangemi S: Chlamydophila psittaci seropositivity and serum levels of soluble intercellular adhesion molecule-1 in farmers. Ann Agric Environ Med. 15:277–280. 2008.PubMed/NCBI | |
Musumeci G, Cardile V, Fenga C, Caggia S and Loreto C: Mineral fibre toxicity: Expression of retinoblastoma (Rb) and phospho-retinoblastoma (pRb) protein in alveolar epithelial and mesothelial cell lines exposed to fluoro-edenite fibres. Cell Biol Toxicol. 27:217–225. 2011. View Article : Google Scholar : PubMed/NCBI | |
Maira F, Catania A, Candido S, Russo AE, McCubrey JA, Libra M, Malaponte G and Fenga C: Molecular targeted therapy in melanoma: A way to reverse resistance to conventional drugs. Curr Drug Deliv. 9:17–29. 2012. View Article : Google Scholar : PubMed/NCBI | |
Rapisarda V, Marconi A, Candido S, Nicolosi D, Salmeri M, Gangemi P, Proietti L, Spandidos DA, Bracci M, Fenga C and Libra M: A tailored health surveillance program unveils a case of MALT lymphoma in an HCV-positive health-care worker. Oncol Lett. 5:651–654. 2013.PubMed/NCBI | |
Candido S, Rapisarda V, Marconi A, Malaponte G, Bevelacqua V, Gangemi P, Scalisi A, McCubrey JA, Maestro R, Spandidos DA, et al: Analysis of the B-RafV600E mutation in cutaneous melanoma patients with occupational sun exposure. Oncol Rep. 31:1079–1082. 2014.PubMed/NCBI | |
Malaponte G, Signorelli SS, Bevelacqua V, Polesel J, Taborelli M, Guarneri C, Fenga C, Umezawa K and Libra M: Increased Levels of NF-κB-Dependent Markers in Cancer-Associated Deep Venous Thrombosis. PLoS One. 10:e01324962015. View Article : Google Scholar : PubMed/NCBI | |
Alavanja MC, Sandler DP, McMaster SB, Zahm SH, McDonnell CJ, Lynch CF, Pennybacker M, Rothman N, Dosemeci M, Bond AE, et al: The Agricultural Health Study. Environ Health Perspect. 104:362–369. 1996. View Article : Google Scholar : PubMed/NCBI | |
Corsini E, Sokooti M, Galli CL, Moretto A and Colosio C: Pesticide induced immunotoxicity in humans: A comprehensive review of the existing evidence. Toxicology. 307:123–135. 2013. View Article : Google Scholar : PubMed/NCBI | |
García-García CR, Parrón T, Requena M, Alarcón R, Tsatsakis AM and Hernández AF: Occupational pesticide exposure and adverse health effects at the clinical, hematological and biochemical level. Life Sci. 145:274–283. 2016. View Article : Google Scholar : PubMed/NCBI | |
Simon-Delso N, Amaral-Rogers V, Belzunces LP, et al: Systemic insecticides (neonicotinoids and fipronil): Trends, uses, mode of action and metabolites. Environ Sci Pollut Res Int. 22:5–34. 2015. View Article : Google Scholar : PubMed/NCBI | |
Dhouib I, Jallouli M, Annabi A, Marzouki S, Gharbi N, Elfazaa S and Lasram MM: From immunotoxicity to carcinogenicity: The effects of carbamate pesticides on the immune system. Environ Sci Pollut Res Int. 23:9448–9458. 2016. View Article : Google Scholar : PubMed/NCBI | |
Weichenthal S, Moase C and Chan P: A review of pesticide exposure and cancer incidence in the Agricultural Health Study cohort. Environ Health Perspect. 118:1117–1125. 2010. View Article : Google Scholar : PubMed/NCBI | |
Gangemi S, Gofita E, Costa C, Teodoro M, Briguglio G, Nikitovic D, Tzanakakis G, Tsatsakis AM, Wilks MF, Spandidos DA and Fenga C: Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases (Review). Int J Mol Med. 38:1012–1020. 2016.PubMed/NCBI | |
Groot MJ and Van't Hooft KE: The Hidden Effects of Dairy Farming on Public and Environmental Health in the Netherlands, India, Ethiopia, and Uganda, Considering the Use of Antibiotics and Other Agro-chemicals. Front Public Health. 4:122016. View Article : Google Scholar : PubMed/NCBI | |
Maroni M, Fanetti AC and Metruccio F: Risk assessment and management of occupational exposure to pesticides in agriculture. Med Lav. 97:430–437. 2006.PubMed/NCBI | |
Hernández Jerez AF, Gil F and Lacasaña M: Integrating epidemiological, mechanistic and experimental toxicology data for pesticide risk assessment. Toxicol Lett. 258:S262016. View Article : Google Scholar | |
Aprea C, Colosio C, Mammone T, Minoia C and Maroni M: Biological monitoring of pesticide exposure: A review of analytical methods. J Chromatogr B Analyt Technol Biomed Life Sci. 769:191–219. 2002. View Article : Google Scholar : PubMed/NCBI | |
Libich S, To JC, Frank R and Sirons GJ: Occupational exposure of herbicide applicators to herbicides used along electric power transmission line right-of-way. Am Ind Hyg Assoc J. 45:56–62. 1984. View Article : Google Scholar : PubMed/NCBI | |
Arbuckle TE, Cole DC, Ritter L and Ripley BD: Biomonitoring of herbicides in Ontario farm applicators. Scand J Work Environ Health. 31:(Suppl 1). 90–97; discussion 63–65. 2005.PubMed/NCBI | |
Rubino FM, Mandic-Rajcevic S, Ariano E, Alegakis A, Bogni M, Brambilla G, DePaschale G, Firmi A, Minoia C, Micoli G, et al: Farmers' exposure to herbicides in North Italy: assessment under real-life conditions in small-size rice and corn. Toxicol Lett. 210:189–197. 2012. View Article : Google Scholar : PubMed/NCBI | |
Aprea C, Terenzoni B, De Angelis V, Sciarra G, Lunghini L, Borzacchi G, Vasconi D, Fani D, Quercia A, Salvan A and Settimi L: Evaluation of skin and respiratory doses and urinary excretion of alkylphosphates in workers exposed to dimethoate during treatment of olive trees. Arch Environ Contam Toxicol. 48:127–134. 2005. View Article : Google Scholar : PubMed/NCBI | |
Flack S, Goktepe I, Ball LM and Nylander-French LA: Development and application of quantitative methods for monitoring dermal and inhalation exposure to propiconazole. J Environ Monit. 10:336–344. 2008. View Article : Google Scholar : PubMed/NCBI | |
Vitali M, Protano C, Del Monte A, Ensabella F and Guidotti M: Operative modalities and exposure to pesticides during open field treatments among a group of agricultural subcontractors. Arch Environ Contam Toxicol. 57:193–202. 2009. View Article : Google Scholar : PubMed/NCBI | |
Organisation For Economic Cο-Operation and Development, . Guidance Document for the Conduct of Studies of Occupational Exposure to Pesticides During Agricultural Application. OECD Publishing; Paris: 2002 | |
Baldi I, Lebailly P, Jean S, Rougetet L, Dulaurent S and Marquet P: Pesticide contamination of workers in vineyards in France. J Expo Sci Environ Epidemiol. 16:115–124. 2006. View Article : Google Scholar : PubMed/NCBI | |
Baldi I, Lebailly P, Bouvier G, Rondeau V, Kientz-Bouchart V, Canal-Raffin M and Garrigou A: Levels and determinants of pesticide exposure in re-entry workers in vineyards: Results of the PESTEXPO study. Environ Res. 132:360–369. 2014. View Article : Google Scholar : PubMed/NCBI | |
Colosio C, Rubino FM, Alegakis A, Ariano E, Brambilla G, Mandic-Rajcevic S, Metruccio F, Minoia C, Moretto A, Somaruga C, et al: Integration of biological monitoring, environmental monitoring and computational modelling into the interpretation of pesticide exposure data: introduction to a proposed approach. Toxicol Lett. 213:49–56. 2012. View Article : Google Scholar : PubMed/NCBI | |
Reffstrup TK, Larsen JC and Meyer O: Risk assessment of mixtures of pesticides. Current approaches and future strategies. Regul Toxicol Pharmacol. 56:174–192. 2010. View Article : Google Scholar : PubMed/NCBI | |
Boverhof DR, Ladics G, Luebke B, Botham J, Corsini E, Evans E, Germolec D, Holsapple M, Loveless SE, Lu H, et al: Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: a workshop summary. Regul Toxicol Pharmacol. 68:96–107. 2014. View Article : Google Scholar : PubMed/NCBI | |
Peters S, Vermeulen R, Portengen L, Olsson A, Kendzia B, Vincent R, Savary B, Lavoué J, Cavallo D, Cattaneo A, et al: SYN-JEM: A Quantitative Job-Exposure Matrix for Five Lung Carcinogens. Ann Occup Hyg. 60:795–811. 2016. View Article : Google Scholar : PubMed/NCBI | |
Alif SM, Dharmage SC, Bowatte G, Karahalios A, Benke G, Dennekamp M, Mehta AJ, Miedinger D, Künzli N, Probst-Hensch N, et al: Occupational exposure and risk of chronic obstructive pulmonary disease: A systematic review and meta-analysis. Expert Rev Respir Med. 10:861–872. 2016. View Article : Google Scholar : PubMed/NCBI | |
Milner A, Niedhammer I, Chastang JF, Spittal MJ and LaMontagne AD: Validity of a Job-Exposure Matrix for Psychosocial Job Stressors: Results from the Household Income and Labour Dynamics in Australia Survey. PLoS One. 11:e01529802016. View Article : Google Scholar : PubMed/NCBI | |
Carles C, Bouvier G, Lebailly P and Baldi I: Use of job-exposure matrices to estimate occupational exposure to pesticides: A review. J Expo Sci Environ Epidemiol. May 18–2016.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI | |
Dosemeci M, Alavanja MC, Rowland AS, Mage D, Zahm SH, Rothman N, Lubin JH, Hoppin JA, Sandler DP and Blair A: A quantitative approach for estimating exposure to pesticides in the Agricultural Health Study. Ann Occup Hyg. 46:245–260. 2002. View Article : Google Scholar : PubMed/NCBI | |
Negatu B, Vermeulen R, Mekonnen Y and Kromhout H: A Method for Semi-quantitative Assessment of Exposure to Pesticides of Applicators and Re-entry Workers: An Application in Three Farming Systems in Ethiopia. Ann Occup Hyg. 60:669–683. 2016. View Article : Google Scholar : PubMed/NCBI | |
Fenga C, Gangemi S and Costa C: Benzene exposure is associated with epigenetic changes (Review). Mol Med Rep. 13:3401–3405. 2016.PubMed/NCBI | |
Orphanides G and Reinberg D: A unified theory of gene expression. Cell. 108:439–451. 2002. View Article : Google Scholar : PubMed/NCBI | |
Grewal SI and Moazed D: Heterochromatin and epigenetic control of gene expression. Science. 301:798–802. 2003. View Article : Google Scholar : PubMed/NCBI | |
Kouzarides T: Chromatin modifications and their function. Cell. 128:693–705. 2007. View Article : Google Scholar : PubMed/NCBI | |
Jackson RJ and Standart N: How do microRNAs regulate gene expression? Sci STKE. 2007:re12007. View Article : Google Scholar : PubMed/NCBI | |
Collotta M, Bertazzi PA and Bollati V: Epigenetics and pesticides. Toxicology. 307:35–41. 2013. View Article : Google Scholar : PubMed/NCBI | |
Stouder C and Paoloni-Giacobino A: Specific transgenerational imprinting effects of the endocrine disruptor methoxychlor on male gametes. Reproduction. 141:207–216. 2011. View Article : Google Scholar : PubMed/NCBI | |
Holland N, Lizarraga D and Huen K: Recent progress in the genetics and epigenetics of paraoxonase: why it is relevant to children's environmental health. Curr Opin Pediatr. 27:240–247. 2015. View Article : Google Scholar : PubMed/NCBI | |
Lee BW, London L, Paulauskis J, Myers J and Christiani DC: Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers. J Occup Environ Med. 45:118–122. 2003. View Article : Google Scholar : PubMed/NCBI | |
Matthews AR, Sutter ME and Rentz DE: Serum paraoxonase-1 (PON-1) genotype and exposure to organophosphorous insectides - is there a high-risk population? J Med Toxicol. 7:243–247. 2011. View Article : Google Scholar : PubMed/NCBI | |
Costa C, Gangemi S, Giambò F, Rapisarda V, Caccamo D and Fenga C: Oxidative stress biomarkers and paraoxonase 1 polymorphism frequency in farmers occupationally exposed to pesticides. Mol Med Rep. 12:6353–6357. 2015.PubMed/NCBI | |
Robertson KD: DNA methylation and human disease. Nat Rev Genet. 6:597–610. 2005. View Article : Google Scholar : PubMed/NCBI | |
Tammen SA, Friso S and Choi SW: Epigenetics: The link between nature and nurture. Mol Aspects Med. 34:753–764. 2013. View Article : Google Scholar : PubMed/NCBI | |
Howard TD, Hsu FC, Chen H, Quandt SA, Talton JW, Summers P and Arcury TA: Changes in DNA methylation over the growing season differ between North Carolina farmworkers and non-farmworkers. Int Arch Occup Environ Health. 89:1103–1110. 2016. View Article : Google Scholar : PubMed/NCBI | |
International Diabetes Federation (IDF), . IDF Diabetes Atlas. 7th. IDF; Brussels: 2015 | |
Hu FB: Globalization of diabetes: The role of diet, lifestyle, and genes. Diabetes Care. 34:1249–1257. 2011. View Article : Google Scholar : PubMed/NCBI | |
Malekirad AA, Faghih M, Mirabdollahi M, Kiani M, Fathi A and Abdollahi M: Neurocognitive, mental health, and glucose disorders in farmers exposed to organophosphorus pesticides. Arh Hig Rada Toksikol. 64:1–8. 2013. View Article : Google Scholar : PubMed/NCBI | |
Montgomery MP, Kamel F, Saldana TM, Alavanja MC and Sandler DP: Incident diabetes and pesticide exposure among licensed pesticide applicators: Agricultural Health Study, 1993–2003. Am J Epidemiol. 167:1235–1246. 2008. View Article : Google Scholar : PubMed/NCBI | |
Starling AP, Umbach DM, Kamel F, Long S, Sandler DP and Hoppin JA: Pesticide use and incident diabetes among wives of farmers in the Agricultural Health Study. Occup Environ Med. 71:629–635. 2014. View Article : Google Scholar : PubMed/NCBI | |
Jaacks LM and Staimez LR: Association of persistent organic pollutants and non-persistent pesticides with diabetes and diabetes-related health outcomes in Asia: A systematic review. Environ Int. 76:57–70. 2015. View Article : Google Scholar : PubMed/NCBI | |
Leso V, Capitanelli I, Lops EA, Ricciardi W and Iavicoli I: Occupational chemical exposure and diabetes mellitus risk. Toxicol Ind Health. Mar 30–2016.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI | |
Wilks MF: Pesticides and Parkinson's disease - What is the evidence from epidemiological and experimental studies? Toxicol Lett. 258:(Suppl). S26–S27. 2016. View Article : Google Scholar | |
Elbaz A and Moisan F: The scientific bases to consider Parkinson's disease an occupational disease in agriculture professionals exposed to pesticides in France. J Epidemiol Community Health. 70:319–321. 2016. View Article : Google Scholar : PubMed/NCBI | |
Yegambaram M, Manivannan B, Beach TG and Halden RU: Role of environmental contaminants in the etiology of Alzheimer's disease: a review. Curr Alzheimer Res. 12:116–146. 2015. View Article : Google Scholar : PubMed/NCBI | |
Kinsley L and Siddique T: Amyotrophic Lateral Sclerosis OverviewGeneReviews® [Internet]. Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Mefford HC, Smith RJH and Stephens K: University of Washington; Seattle, WA: pp. 1993–2016. Mar 23–2001, [updated Feb 12, 2015]. | |
Hernández AF, González-Alzaga B, López-Flores I and Lacasaña M: Systematic reviews on neurodevelopmental and neurodegenerative disorders linked to pesticide exposure: Methodological features and impact on risk assessment. Environ Int. 92–93:657–679. 2016. View Article : Google Scholar : PubMed/NCBI | |
Ritz BR, Paul KC and Bronstein JM: Of Pesticides and Men: A California Story of Genes and Environment in Parkinson's Disease. Curr Environ Health Rep. 3:40–52. 2016. View Article : Google Scholar : PubMed/NCBI | |
Wang A, Cockburn M, Ly TT, Bronstein JM and Ritz B: The association between ambient exposure to organophosphates and Parkinson's disease risk. Occup Environ Med. 71:275–281. 2014. View Article : Google Scholar : PubMed/NCBI | |
Freire C and Koifman S: Pesticide exposure and Parkinson's disease: epidemiological evidence of association. Neurotoxicology. 33:947–971. 2012. View Article : Google Scholar : PubMed/NCBI | |
Dardiotis E, Xiromerisiou G, Hadjichristodoulou C, Tsatsakis AM, Wilks MF and Hadjigeorgiou GM: The interplay between environmental and genetic factors in Parkinson's disease susceptibility: The evidence for pesticides. Toxicology. 07:17–23. 2013. View Article : Google Scholar | |
Vinken M: The adverse outcome pathway concept: A pragmatic tool in toxicology. Toxicology. 312:158–165. 2013. View Article : Google Scholar : PubMed/NCBI | |
Groh KJ, Carvalho RN, Chipman JK, Denslow ND, Halder M, Murphy CA, Roelofs D, Rolaki A, Schirmer K and Watanabe KH: Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology. Chemosphere. 120:764–77. 2015. View Article : Google Scholar : PubMed/NCBI | |
European Food Safety Authority (EFSA), . Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia. EFSA Journal, Parma. 2016. | |
Kamel F, Umbach DM, Bedlack RS, Richards M, Watson M, Alavanja MC, Blair A, Hoppin JA, Schmidt S and Sandler DP: Pesticide exposure and amyotrophic lateral sclerosis. Neurotoxicology. 33:457–462. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kang H, Cha ES, Choi GJ and Lee WJ: Amyotrophic lateral sclerosis and agricultural environments: A systematic review. J Korean Med Sci. 29:1610–1617. 2014. View Article : Google Scholar : PubMed/NCBI | |
González-Alzaga B, Lacasaña M, Aguilar-Garduño C, Rodríguez Barranco M, Ballester F, Rebagliato M and Hernández AF: A systematic review of neurodevelopmental effects of prenatal and postnatal organophosphate pesticide exposure. Toxicol Lett. 15:104–121. 2014. View Article : Google Scholar | |
Muñoz-Quezada MT, Lucero BA, Barr DB, Steenland K, Levy K, Ryan PB, Iglesias V, Alvarado S, Concha C, Rojas E, et al: Neurodevelopmental effects in children associated with exposure to organophosphate pesticides: A systematic review. Neurotoxicology. 39:158–168. 2013. View Article : Google Scholar : PubMed/NCBI | |
Reynolds LP and Caton JS: Role of the pre- and post-natal environment in developmental programming of health and productivity. Mol Cell Endocrinol. 6:54–59. 2012. View Article : Google Scholar | |
Hanke W and Jurewicz J: The risk of adverse reproductive and developmental disorders due to occupational pesticide exposure: An overview of current epidemiological evidence. Int J Occup Med Environ Health. 17:223–243. 2004.PubMed/NCBI | |
Kumar S: Occupational exposure associated with reproductive dysfunction. J Occup Health. 46:1–19. 2004. View Article : Google Scholar : PubMed/NCBI | |
Arbuckle TE, Lin Z and Mery LS: An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population. Environ Health Perspect. 109:851–857. 2001. View Article : Google Scholar : PubMed/NCBI | |
Jurewicz J, Hanke W and Makowiec-Dabrowska T: Low risk of reproductive disorders among female greenhouse workers - safe work conditions or health selection for the light work? Med Pr. 59:123–131. 2008.(In Polish). PubMed/NCBI | |
Jurewicz J and Hanke W: Risk of reproductive disorders in greenhouse workers. Med Pr. 58:433–438. 2007.(In Polish). PubMed/NCBI | |
Miranda-Contreras L, Cruz I, Osuna JA, Gómez-Pérez R, Berrueta L, Salmen S, Colmenares M, Barreto S, Balza A, Morales Y, et al: Effects of occupational exposure to pesticides on semen quality of workers in an agricultural community of Merida state, Venezuela. Invest Clin. 56:123–136. 2015.(In Spanish). PubMed/NCBI | |
Radwan M, Jurewicz J, Wielgomas B, Piskunowicz M, Sobala W, Radwan P, Jakubowski L, Hawuła W and Hanke W: The association between environmental exposure to pyrethroids and sperm aneuploidy. Chemosphere. 128:42–48. 2015. View Article : Google Scholar : PubMed/NCBI | |
Jamal F, Haque QS, Singh S and Rastogi S: The influence of organophosphate and carbamate on sperm chromatin and reproductive hormones among pesticide sprayers. Toxicol Ind Health. 32:1527–1536. 2015. | |
Neghab M, Momenbella-Fard M, Naziaghdam R, Salahshour N, Kazemi M and Alipour H: The effects of exposure to pesticides on the fecundity status of farm workers resident in a rural region of Fars province, southern Iran. Asian Pac J Trop Biomed. 4:324–328. 2014. View Article : Google Scholar : PubMed/NCBI | |
Polesel J, Franceschi S, Talamini R, Negri E, Barzan L, Montella M, Libra M, Vaccher E, Franchin G, La Vecchia C, et al: Tobacco smoking, alcohol drinking, and the risk of different histological types of nasopharyngeal cancer in a low-risk population. Oral Oncol. 47:541–545. 2011. View Article : Google Scholar : PubMed/NCBI | |
Clapp RW, Jacobs MM and Loechler EL: Environmental and occupational causes of cancer: New evidence 2005–2007. Rev Environ Health. 23:1–37. 2008. View Article : Google Scholar : PubMed/NCBI | |
Del Pup L, Mantovani A, Luce A, Cavaliere C, Facchini G, Di Francia R, Caraglia M and Berretta M: Endocrine disruptors and female cancer: Informing the patients (Review). Oncol Rep. 34:3–11. 2015.PubMed/NCBI | |
Schinasi L and Leon ME: Non-Hodgkin lymphoma and occupational exposure to agricultural pesticide chemical groups and active ingredients: a systematic review and meta-analysis. Int J Environ Res Public Health. 11:4449–4527. 2014. View Article : Google Scholar : PubMed/NCBI | |
Lewis-Mikhael AM, Bueno-Cavanillas A, Guiron T Ofir, Olmedo-Requena R, Delgado-Rodríguez M and Jiménez-Moleón JJ: Occupational exposure to pesticides and prostate cancer: A systematic review and meta-analysis. Occup Environ Med. 73:134–144. 2016. View Article : Google Scholar : PubMed/NCBI | |
Doolan G, Benke G and Giles G: An update on occupation and prostate cancer. Asian Pac J Cancer Prev. 15:501–516. 2014. View Article : Google Scholar : PubMed/NCBI | |
Sokolosky ML, Stadelman KM, Chappell WH, Abrams SL, Martelli AM, Stivala F, Libra M, Nicoletti F, Drobot LB, Franklin RA, et al: Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy. Oncotarget. 2:538–550. 2011. View Article : Google Scholar : PubMed/NCBI | |
McCubrey JA, Abrams SL, Ligresti G, Misaghian N, Wong EW, Steelman LS, Bäsecke J, Troppmair J, Libra M, Nicoletti F, et al: Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance. Leukemia. 22:2080–2090. 2008. View Article : Google Scholar : PubMed/NCBI | |
McCubrey JA, Steelman LS, Franklin RA, Abrams SL, Chappell WH, Wong EW, Lehmann BD, Terrian DM, Basecke J, Stivala F, et al: Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance. Adv Enzyme Regul. 47:64–103. 2007. View Article : Google Scholar : PubMed/NCBI | |
Hernández AF and Menéndez P: Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms. Int J Mol Sci. 17:4612016. View Article : Google Scholar : PubMed/NCBI | |
Fenga C, Gangemi S, Catania S, De Luca A and Costa C: IL-17 and IL-22 serum levels in greenhouse workers exposed to pesticides. Inflamm Res. 63:895–897. 2014. View Article : Google Scholar : PubMed/NCBI | |
Costa C, Rapisarda V, Catania S, Di Nola C, Ledda C and Fenga C: Cytokine patterns in greenhouse workers occupationally exposed to α-cypermethrin: An observational study. Environ Toxicol Pharmacol. 36:796–800. 2013. View Article : Google Scholar : PubMed/NCBI |