Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes

  • Authors:
    • Guiying Chen
    • Hong Guo
    • Ying Song
    • Huiying Chang
    • Shaojun Wang
    • Miaomiao Zhang
    • Chang Liu
  • View Affiliations

  • Published online on: October 26, 2016     https://doi.org/10.3892/mmr.2016.5893
  • Pages: 5311-5317
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Abstract

The role of long non-coding RNAs (lncRNAs) in atrial fibrillation remains to be fully elucidated. The current study performed microarray analysis to investigate differential lncRNA expression profiling in atrial samples from the pulmonary vein and the surrounding left atrial area (LA‑PV) and from the left atrial appendage (LAA) in 16 patients with atrial fibrillation (AF). Microarray analysis identified 94 lncRNAs that were differentially expressed between the LA‑PV and LAA in patients with AF. AK055347 was one of lncRNAs with the most significant alterations observed. Knockdown of AK055347 inhibited cell viability of H9C2 cardiomyocytes, accompanied by downregulation of Cyp450 and ATP synthases. In addition, microarray analysis identified that MSS51 was a target of AK055347. Knockdown of AK055347 inhibited the expression of MSS51 in H9C2 cells. The observations of the current study suggest that lncRNAs are differentially expressed in the LA‑PV and LAA in patients with AF. AK055347 may contribute to the pathogenesis of AF by dysregulating mitochondrial energy production via regulation of Cyp450, ATP synthase and MSS51.
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December-2016
Volume 14 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Chen G, Guo H, Song Y, Chang H, Wang S, Zhang M and Liu C: Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes. Mol Med Rep 14: 5311-5317, 2016.
APA
Chen, G., Guo, H., Song, Y., Chang, H., Wang, S., Zhang, M., & Liu, C. (2016). Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes. Molecular Medicine Reports, 14, 5311-5317. https://doi.org/10.3892/mmr.2016.5893
MLA
Chen, G., Guo, H., Song, Y., Chang, H., Wang, S., Zhang, M., Liu, C."Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes". Molecular Medicine Reports 14.6 (2016): 5311-5317.
Chicago
Chen, G., Guo, H., Song, Y., Chang, H., Wang, S., Zhang, M., Liu, C."Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes". Molecular Medicine Reports 14, no. 6 (2016): 5311-5317. https://doi.org/10.3892/mmr.2016.5893