Open Access

Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways

  • Authors:
    • Xiaohua Shen
    • Meihui Wang
    • Xukun Bi
    • Jiefang Zhang
    • Shaoxiang Wen
    • Guosheng Fu
    • Liang Xia
  • View Affiliations

  • Published online on: November 7, 2016     https://doi.org/10.3892/mmr.2016.5929
  • Pages: 5528-5534
  • Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Increasing evidence suggests endothelial progenitor cells (EPCs) improve neovascularization and endothelium regeneration. Resveratrol (RSV) is a natural polyphenolic compound, which has been demonstrated to exert multiple protective effects on the cardiovascular system, including inhibition of platelet adhesion and aggregation, reduction of myocardial ischemia‑reperfusion injury, and suppression of neointimal hyperplasia of injured vascular tissue. The present study investigated the role of RSV on levels of oxidative stress and senescence of EPCs, and the effects of RSV on vascular‑promoting and/or vascular‑healing capacity of EPCs. It was demonstrated that EPCs could promote the repair of endothelium of the injured artery. RSV reduced the oxidative reaction of EPCs and inhibited EPC senescence, and these effects may occur via the peroxisome proliferator‑activated receptor‑γ/heme oxygenase‑1 signaling pathways.
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December-2016
Volume 14 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Shen X, Wang M, Bi X, Zhang J, Wen S, Fu G and Xia L: Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways. Mol Med Rep 14: 5528-5534, 2016.
APA
Shen, X., Wang, M., Bi, X., Zhang, J., Wen, S., Fu, G., & Xia, L. (2016). Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways. Molecular Medicine Reports, 14, 5528-5534. https://doi.org/10.3892/mmr.2016.5929
MLA
Shen, X., Wang, M., Bi, X., Zhang, J., Wen, S., Fu, G., Xia, L."Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways". Molecular Medicine Reports 14.6 (2016): 5528-5534.
Chicago
Shen, X., Wang, M., Bi, X., Zhang, J., Wen, S., Fu, G., Xia, L."Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways". Molecular Medicine Reports 14, no. 6 (2016): 5528-5534. https://doi.org/10.3892/mmr.2016.5929