Open Access

Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells

  • Authors:
    • Jinjing Jia
    • Yan Zheng
    • Wei Wang
    • Yongping Shao
    • Zhengxiao Li
    • Qiong Wang
    • Yuan Wang
    • Huling Yan
  • View Affiliations

  • Published online on: December 2, 2016     https://doi.org/10.3892/mmr.2016.5978
  • Pages: 240-248
  • Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The cathelicidin antimicrobial peptide, LL-37, is a multifunctional peptide with a broad spectrum of antimicrobial activities, such as chemotaxis and neutralizing endotoxins. Previous studies have demonstrated that it LL‑37 serves a functional role in the development of numerous types of cancer including ovarian, breast, prostate and lung cancer. However, its role in the development of malignant melanoma (MM) remains unclear. To determine the role of LL‑37 and the potential interaction with Y-box binding protein 1 (YB‑1) in MM, RNA interference, western blot, reverse transcription-quantitative polymerase chain reaction, MTT and Transwell assays were performed. The current study demonstrated that LL‑37 induced YB‑1 expression, and increased tumor cell proliferation, migration and invasion of A375 and A875 MM cell lines. In addition, inhibition of nuclear factor‑κB (NF‑κB) attenuated LL‑37‑induced YB‑1 expression. These results demonstrate that, through the upregulation of YB‑1 expression and the activation of the NF‑κB signaling pathway, LL‑37 may promote the malignant progression of MM cells in vitro.
View Figures
View References

Related Articles

Journal Cover

January-2017
Volume 15 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Jia J, Zheng Y, Wang W, Shao Y, Li Z, Wang Q, Wang Y and Yan H: Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells. Mol Med Rep 15: 240-248, 2017
APA
Jia, J., Zheng, Y., Wang, W., Shao, Y., Li, Z., Wang, Q. ... Yan, H. (2017). Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells. Molecular Medicine Reports, 15, 240-248. https://doi.org/10.3892/mmr.2016.5978
MLA
Jia, J., Zheng, Y., Wang, W., Shao, Y., Li, Z., Wang, Q., Wang, Y., Yan, H."Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells". Molecular Medicine Reports 15.1 (2017): 240-248.
Chicago
Jia, J., Zheng, Y., Wang, W., Shao, Y., Li, Z., Wang, Q., Wang, Y., Yan, H."Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells". Molecular Medicine Reports 15, no. 1 (2017): 240-248. https://doi.org/10.3892/mmr.2016.5978