Open Access

Surgically‑induced mouse models in the study of bone regeneration: Current models and future directions (Review)

  • Authors:
    • Bin Ning
    • Yunpeng Zhao
    • John A. Buza III
    • Wei Li
    • Wenzhao Wang
    • Tanghong Jia
  • View Affiliations

  • Published online on: January 26, 2017     https://doi.org/10.3892/mmr.2017.6155
  • Pages: 1017-1023
  • Copyright: © Ning et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bone regeneration has been extensively studied over the past several decades. The surgically‑induced mouse model is the key animal model for studying bone regeneration, of the various research strategies used. These mouse models mimic the trauma and recovery processes in vivo and serve as carriers for tissue engineering and gene modification to test various therapies or associated genes in bone regeneration. The present review introduces a classification of surgically induced mouse models in bone regeneration, evaluates the application and value of these models and discusses the potential development of further innovations in this field in the future.
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March-2017
Volume 15 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Ning B, Zhao Y, Buza III JA, Li W, Wang W and Jia T: Surgically‑induced mouse models in the study of bone regeneration: Current models and future directions (Review). Mol Med Rep 15: 1017-1023, 2017.
APA
Ning, B., Zhao, Y., Buza III, J.A., Li, W., Wang, W., & Jia, T. (2017). Surgically‑induced mouse models in the study of bone regeneration: Current models and future directions (Review). Molecular Medicine Reports, 15, 1017-1023. https://doi.org/10.3892/mmr.2017.6155
MLA
Ning, B., Zhao, Y., Buza III, J. A., Li, W., Wang, W., Jia, T."Surgically‑induced mouse models in the study of bone regeneration: Current models and future directions (Review)". Molecular Medicine Reports 15.3 (2017): 1017-1023.
Chicago
Ning, B., Zhao, Y., Buza III, J. A., Li, W., Wang, W., Jia, T."Surgically‑induced mouse models in the study of bone regeneration: Current models and future directions (Review)". Molecular Medicine Reports 15, no. 3 (2017): 1017-1023. https://doi.org/10.3892/mmr.2017.6155