Curcumin inhibits hypoxia-induced proliferation and invasion of MG-63 osteosarcoma cells via downregulating Notch1

  • Authors:
    • Zhan Wang
    • Kun Zhang
    • Yangjun Zhu
    • Dengfeng Wang
    • Yuxiong Shao
    • Jun Zhang
  • View Affiliations

  • Published online on: January 30, 2017     https://doi.org/10.3892/mmr.2017.6159
  • Pages: 1747-1752
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Abstract

Curcumin is a biologically active ingredient abundantly present in the ground rhizomes of Curcuma longa with a wide range of bioactive properties, including antitumor effects. Hypoxia is a common characteristic of solid tumors, including osteosarcoma. However, whether curcumin has antitumor effects on osteosarcoma under hypoxic conditions, and its underlying molecular mechanisms, remain unclear. The present study demonstrated that the MG‑63 osteosarcoma cell line exhibited increased proliferation and enhanced invasiveness upon exposure to hypoxic conditions. However, these effects were prevented by curcumin treatment. Further investigation revealed that curcumin may inhibit Notch1 upregulation induced by hypoxia. Overexpression of Notch1 via Notch1 cDNA transfection ameliorated curcumin‑inhibited MG‑63 cell growth under hypoxic conditions. Taken together, these data revealed that curcumin may suppress the growth of osteosarcoma cells in hypoxia via inhibiting Notch1 signaling.
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April-2017
Volume 15 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang Z, Zhang K, Zhu Y, Wang D, Shao Y and Zhang J: Curcumin inhibits hypoxia-induced proliferation and invasion of MG-63 osteosarcoma cells via downregulating Notch1. Mol Med Rep 15: 1747-1752, 2017
APA
Wang, Z., Zhang, K., Zhu, Y., Wang, D., Shao, Y., & Zhang, J. (2017). Curcumin inhibits hypoxia-induced proliferation and invasion of MG-63 osteosarcoma cells via downregulating Notch1. Molecular Medicine Reports, 15, 1747-1752. https://doi.org/10.3892/mmr.2017.6159
MLA
Wang, Z., Zhang, K., Zhu, Y., Wang, D., Shao, Y., Zhang, J."Curcumin inhibits hypoxia-induced proliferation and invasion of MG-63 osteosarcoma cells via downregulating Notch1". Molecular Medicine Reports 15.4 (2017): 1747-1752.
Chicago
Wang, Z., Zhang, K., Zhu, Y., Wang, D., Shao, Y., Zhang, J."Curcumin inhibits hypoxia-induced proliferation and invasion of MG-63 osteosarcoma cells via downregulating Notch1". Molecular Medicine Reports 15, no. 4 (2017): 1747-1752. https://doi.org/10.3892/mmr.2017.6159