Inhibition of triggering receptor expressed on myeloid cells-1 ameliorates experimental autoimmune neuritis

Zhou,Xiaoliang; Wang,Yanli; Wang,Yuzhong; Cipriano,Peter; Xiao,Bo; Zhou,Wenbin

doi:10.3892/mmr.2017.6167

Inhibition of triggering receptor expressed on myeloid cells-1 ameliorates experimental autoimmune neuritis

Authors:
- Xiaoliang Zhou
- Yanli Wang
- Yuzhong Wang
- Peter Cipriano
- Bo Xiao
- Wenbin Zhou
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Affiliations: Department of Neurology, Xiangya Hospital, Central‑South University, Changsha, Hunan 410008, P.R. China, Department of Neurology, Jingzhou Central Hospital, Jingzhou, Hubei 434020, P.R. China, Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China, Department of Radiology, Stanford Medical Center, Stanford, CA 94305, USA
Published online on: February 6, 2017 https://doi.org/10.3892/mmr.2017.6167
Pages: 1565-1570
Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Experimental autoimmune neuritis (EAN) is a cluster of differentiation 4+ T helper 1 cell-mediated inflammatory demyelinating disease of the peripheral nervous system and serves as a useful animal model for Guillain‑Barré syndrome. Triggering receptor expressed on myeloid cells‑1 (TREM‑1) is an important receptor involved in sepsis and the innate inflammatory response. Linear plasmid 17 (LP 17) peptide is a competitive antagonist of TREM‑1. To investigate the role of TREM‑1 in EAN, 64 male Lewis rats were randomly divided into four groups: Normal saline, complete Freund's adjuvant, EAN and LP 17. The present study assessed the mRNA expression levels of TREM‑1, tumor necrosis factor‑α and interleukin‑1β in sciatic nerves and peripheral blood mononuclear cells. The results demonstrated that inhibiting TREM-1 by administering LP 17 ameliorated symptoms and reduced inflammation in EAN rats. The present study concluded that TREM‑1 may be involved in the pathogenesis of EAN, and that inhibition of TREM-1 may ameliorate EAN.

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