Periostin is essential for periodontal ligament remodeling during orthodontic treatment

  • Authors:
    • Hui‑Yong Xu
    • Er‑Min Nie
    • Gang Deng
    • Ling‑Zhi Lai
    • Feng‑Yang Sun
    • Hua Tian
    • Fu‑Chun Fang
    • Ya‑Guang Zou
    • Bu‑Ling Wu
    • Jun Ou‑Yang
  • View Affiliations

  • Published online on: February 13, 2017     https://doi.org/10.3892/mmr.2017.6200
  • Pages: 1800-1806
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Abstract

Orthodontic tooth movement is a process stimulated and maintained by external tensile stress; periodontal ligament remodeling serves an important role during this process. However, the function and underlying mechanism of periostin (PN) during orthodontic periodontal ligament remodeling remain unclear. The present study established in vitro and in vivo models of orthodontic treatment to investigate the expression levels of PN under conditions of external tensile stress load. These results indicated that tensile stress load increased the expression levels of PN in mouse peridontal ligaments and human periodontal ligament cells (hPDLCs), during orthodontic tooth movement. Furthermore, the present study demonstrated that the expression levels of PN were regulated by transforming grown factor β, and that PN promotes type I collagen and α‑smooth muscle actin expression levels in hPDLCs. Therefore, PN may be essential for periodontal ligament remodeling during orthodontic treatment, and therefore may represent a potential therapeutic target.
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April-2017
Volume 15 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Xu HY, Nie EM, Deng G, Lai LZ, Sun FY, Tian H, Fang FC, Zou YG, Wu BL, Ou‑Yang J, Ou‑Yang J, et al: Periostin is essential for periodontal ligament remodeling during orthodontic treatment. Mol Med Rep 15: 1800-1806, 2017
APA
Xu, H., Nie, E., Deng, G., Lai, L., Sun, F., Tian, H. ... Ou‑Yang, J. (2017). Periostin is essential for periodontal ligament remodeling during orthodontic treatment. Molecular Medicine Reports, 15, 1800-1806. https://doi.org/10.3892/mmr.2017.6200
MLA
Xu, H., Nie, E., Deng, G., Lai, L., Sun, F., Tian, H., Fang, F., Zou, Y., Wu, B., Ou‑Yang, J."Periostin is essential for periodontal ligament remodeling during orthodontic treatment". Molecular Medicine Reports 15.4 (2017): 1800-1806.
Chicago
Xu, H., Nie, E., Deng, G., Lai, L., Sun, F., Tian, H., Fang, F., Zou, Y., Wu, B., Ou‑Yang, J."Periostin is essential for periodontal ligament remodeling during orthodontic treatment". Molecular Medicine Reports 15, no. 4 (2017): 1800-1806. https://doi.org/10.3892/mmr.2017.6200