Sevoflurane downregulates IGF‑1 via microRNA‑98

  • Authors:
    • Jue Jiang
    • Zhifeng Chen
    • Yaqiong Yang
    • Jia Yan
    • Hong Jiang
  • View Affiliations

  • Published online on: February 17, 2017     https://doi.org/10.3892/mmr.2017.6219
  • Pages: 1863-1868
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Abstract

Insulin-like growth factor (IGF)-1 functions as a neuroprotective hormone and may protect against cognitive impairment, which may occur as a result of sevoflurane exposure. The aim of the present study was to assess the effect of sevoflurane on the production of IGF‑1 and investigate the molecular mechanisms underlying this regulation. The BRL rat hepatocyte cell line and adult mice were exposed to 1 or 2 minimal alveolar concentrations sevoflurane for 4 or 8 h. IGF‑1 and microRNA‑98 levels were quantified using an enzyme‑linked immunosorbent assay, western blotting and reverse transcription‑quantitative polymerase chain reaction analyses. The importance of microRNA‑98 in the regulation of IGF‑1 by sevoflurane was investigated using a microRNA‑98 inhibitor. Sevoflurane treatment reduced IGF‑1 levels and simultaneously upregulated microRNA‑98 expression levelsin rat hepatocytes and adult mice. Inhibition of microRNA‑98 attenuated this effect. Therefore, sevoflurane may reduce the synthesis of IGF‑1 by upregulating microRNA‑98 expression.
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April-2017
Volume 15 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Jiang J, Chen Z, Yang Y, Yan J and Jiang H: Sevoflurane downregulates IGF‑1 via microRNA‑98. Mol Med Rep 15: 1863-1868, 2017
APA
Jiang, J., Chen, Z., Yang, Y., Yan, J., & Jiang, H. (2017). Sevoflurane downregulates IGF‑1 via microRNA‑98. Molecular Medicine Reports, 15, 1863-1868. https://doi.org/10.3892/mmr.2017.6219
MLA
Jiang, J., Chen, Z., Yang, Y., Yan, J., Jiang, H."Sevoflurane downregulates IGF‑1 via microRNA‑98". Molecular Medicine Reports 15.4 (2017): 1863-1868.
Chicago
Jiang, J., Chen, Z., Yang, Y., Yan, J., Jiang, H."Sevoflurane downregulates IGF‑1 via microRNA‑98". Molecular Medicine Reports 15, no. 4 (2017): 1863-1868. https://doi.org/10.3892/mmr.2017.6219