Inhibition of varicella‑zoster virus replication by an ethanol extract of Lysimachia mauritiana
- Authors:
View Affiliations
Affiliations: Department of Life Science, Gachon University, Seongnam‑Si, Kyeonggi‑Do 461‑701, Republic of Korea
- Published online on: April 7, 2017 https://doi.org/10.3892/mmr.2017.6444
-
Pages:
3847-3851
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
Varicella‑zoster virus (VZV), a ubiquitous human α‑herpesvirus, is the causative agent of chickenpox and shingles. In the present study, we investigated the antiviral activity of a 70% ethanol extract of Lysimachia mauritiana (LME) against VZV. LME strongly interfered with the replication of both laboratory and clinical strains of VZV without affecting the viability of MRC‑5 cells. Moreover, LME treatment suppressed the expression of an essential viral transactivator, immediate‑early 62 protein (IE62), in addition to other lytic genes in the later phases of viral replication. The finding that LME exerts potent inhibitory effects on VZV gene expression and replication supports its potential utility as a therapeutic anti‑viral agent.
View References
|
1
|
Arvin AM and Gilden D: Varicella-zoster
virusFields Virology. Knipe DM and Howley PM: 6th. Lippincott
Williams & Wilkins; Philadelphia, PA: pp. 2015–2057. 2013
|
|
2
|
Zerboni L, Sen N, Oliver SL and Arvin AM:
Molecular mechanisms of varicella zoster virus pathogenesis. Nat
Rev Microbiol. 12:197–210. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Cohen JI, Brunell PA, Straus SE and Krause
PR: Recent advances in varicella-zoster virus infection. Ann Intern
Med. 130:922–932. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
To KP, Kang SC and Song YJ: The extract of
Elaeocarpussylvestris inhibits human cytomegalovirus immediate
early gene expression and replication in vitro. Mol Med Rep.
9:744–748. 2014.PubMed/NCBI
|
|
5
|
Arvin AM: Varicella-zoster virus. Clin
Microbiol Rev. 9:361–381. 1996.PubMed/NCBI
|
|
6
|
Zerboni L, Ku CC, Jones CD, Zehnder JL and
Arvin AM: Varicella-zoster virus infection of human dorsal root
ganglia in vivo. Proc Natl Acad Sci USA. 102:pp. 6490–6495. 2005;
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Sasivimolphan P, Lipipun V,
Likhitwitayawuid K, Takemoto M, Pramyothin P, Hattori M and Shiraki
K: Inhibitory activity of oxyresveratrol on wild-type and
drug-resistant varicella-zoster virus replication in vitro.
Antiviral Res. 84:95–97. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Docherty JJ, Sweet TJ, Bailey E, Faith SA
and Booth T: Resveratrol inhibition of varicella-zoster virus
replication in vitro. Antiviral Res. 72:171–177. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Choi EJ, Lee CH, Kim YC and Shin OS:
Wogonin inhibits Varicella-Zoster (shingles) virus replication via
modulation of type I interferon signaling and adenosine
monophosphate-activated protein kinase activity. J Funct Foods.
17:399–409. 2015. View Article : Google Scholar
|
|
10
|
Gilden D, Mahalingam R, Nagel MA,
Pugazhenthi S and Cohrs RJ: Review: The neurobiology of varicella
zoster virus infection. Neuropathol Appl Neurobiol. 37:441–463.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Won YH, Kim JI, Kim YY and Lee CH:
Characterization of the repeat sequences of varicella-zoster virus.
J Bacteriol Virol. 44:326–335. 2014. View Article : Google Scholar
|
|
12
|
Kim SY, Kim JE, Won J and Song YJ:
Characterization of the rapamycin-inducible EBV LMP1 activation
system. J Microbiol. 53:732–738. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Kono Y, Chung KF, Chen CH, Hoshi Y,
Setoguchi H, Chou CH, Oginuma K and Peng CI: Intraspecific
karyotypic polymorphism is highly concordant with allozyme
variation in Lysimachia mauritiana (Primulaceae: Myrsinoideae) in
Taiwan: implications for the colonization history and dispersal
patterns of coastal plants. Ann Bot. 110:1119–1135. 2012.
View Article : Google Scholar : PubMed/NCBI
|
