Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population

Liu,Guang‑Jian; He,Jian‑Rong; Kuang,Ya‑Shu; Fan,Xue‑Jiao; Li,Wei‑Dong; Lu,Jin‑Hua; Xia,Xiao‑Yan; Liu,Xiao‑Dan; Chen,Nian‑Nian; Mai,Wei‑Bi; Xia,Hui‑Min; Qiu,Xiu

doi:10.3892/mmr.2017.6475

Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population

Authors:
- Guang‑Jian Liu
- Jian‑Rong He
- Ya‑Shu Kuang
- Xue‑Jiao Fan
- Wei‑Dong Li
- Jin‑Hua Lu
- Xiao‑Yan Xia
- Xiao‑Dan Liu
- Nian‑Nian Chen
- Wei‑Bi Mai
- Hui‑Min Xia
- Xiu Qiu
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Affiliations: Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, P.R. China, Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, P.R. China
Published online on: April 12, 2017 https://doi.org/10.3892/mmr.2017.6475
Pages: 3607-3614
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Preterm birth is the leading cause of mortality and morbidity in infants. Its etiology is multifactorial with genes and immune homeostasis. The authors investigated whether prostaglandin (PG) synthesis related single nucleotide polymorphisms (SNPs) PLA2G4C rs1366442 and PLA2G4D rs4924618 were associated with the risk of spontaneous preterm birth (SPTB) in a Chinese population of 114 cases of SPTB and 250 controls of term delivery. The risk associations were determined by odds ratios (ORs) and their 95% confidence intervals (CIs) calculated using multivariate logistic regression. Homology modeling was performed to elucidate potential mechanism of the SNP function. The maternal AT/TT genotype of PLA2G4D rs4924618 was associated with a reduced risk of SPTB (OR, 0.61; 95% CI, 0.37‑0.99), while no significant association between PLA2G4C rs1366442 and SPTB risk was identified. Structure and sequence analysis revealed that the amino acid substitution introduced by this SNP located at the conserved central core of the catalytic domain of cytosolic phospholipase A2 δ and was close to the active site. These findings suggested that the polymorphism of PLA2G4D rs4924618 may have a protective influence on the SPTB susceptibility in a Chinese population, supporting a role for genetics in the association between PG synthesis and preterm birth.

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