Open Access

Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma

  • Authors:
    • Junqiang Dai
    • Qiao Li
    • Zhitong Bing
    • Yinian Zhang
    • Liang Niu
    • Hang Yin
    • Guoqiang Yuan
    • Yawen Pan
  • View Affiliations

  • Published online on: April 20, 2017     https://doi.org/10.3892/mmr.2017.6490
  • Pages: 4109-4115
  • Copyright: © Dai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Medulloblastoma is the most common malignant brain tumor of the central nervous system among children. Medulloblastoma is an embryonal tumor, of which little is known about the pathogenesis. Several efforts have been made to understand the molecular aspects of its tumorigenic pathways; however, these are poorly understood. microRNA (miRNA), a type of non‑coding short RNA, has been proven to be associated with a number of physiological processes and pathological processes of serious diseases, including brain tumors. Differentially expressed miRNAs serve an important role in numerous types of malignancy. The present study aims to define a differentially expressed set of miRNAs in medulloblastoma tumor tissue, compared with normal samples, to improve the understanding of the tumorigenesis. It was identified that 22 miRNAs were upregulated and 26 miRNAs were downregulated in the tumor tissue compared with the normal group. However, when the medulloblastoma tissue was compared with normal cerebellum tissue, 9 miRNAs were identified to be up or downregulated in the tumor samples. The differentially expressed miRNAs in the tumor tissue were identified in order to clarify the networks and pathways of tumorigenesis using Ingenuity Pathway Analysis. Subsequently, key regulatory genes associated with the development of medulloblastoma were identified, including tumor protein p53, insulin like growth factor 1 receptor, argonaute 2, mitogen‑activated protein kinases 1 and 3, sirtuin 1 and Y box binding protein 1.
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June-2017
Volume 15 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Dai J, Li Q, Bing Z, Zhang Y, Niu L, Yin H, Yuan G and Pan Y: Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma. Mol Med Rep 15: 4109-4115, 2017
APA
Dai, J., Li, Q., Bing, Z., Zhang, Y., Niu, L., Yin, H. ... Pan, Y. (2017). Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma. Molecular Medicine Reports, 15, 4109-4115. https://doi.org/10.3892/mmr.2017.6490
MLA
Dai, J., Li, Q., Bing, Z., Zhang, Y., Niu, L., Yin, H., Yuan, G., Pan, Y."Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma". Molecular Medicine Reports 15.6 (2017): 4109-4115.
Chicago
Dai, J., Li, Q., Bing, Z., Zhang, Y., Niu, L., Yin, H., Yuan, G., Pan, Y."Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma". Molecular Medicine Reports 15, no. 6 (2017): 4109-4115. https://doi.org/10.3892/mmr.2017.6490