Open Access

Investigation of the major cytochrome P450 1A2 genetic variant in a healthy Tibetan population in China

  • Authors:
    • Yongchao Ren
    • Fang Liu
    • Xugang Shi
    • Tingting Geng
    • Dongya Yuan
    • Li Wang
    • Longli Kang
    • Tianbo Jin
    • Chao Chen
  • View Affiliations

  • Published online on: May 29, 2017     https://doi.org/10.3892/mmr.2017.6645
  • Pages: 573-580
  • Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The cytochrome P450 (CYP) 1A2 gene is involved in the metabolism of several carcinogens and clinically important drugs, generating a high potential for pharmacokinetic interactions. Since no data are available for Tibetan aborigines, the present study aimed to investigate the distribution of variant CYP1A2 alleles in a population living in Tibetan region of China. Genotyping analyses of CYP1A2 were conducted in 96 unrelated, healthy volunteers of Tibetan ancestry using direct sequencing assays. A total of 14 different CYP1A2 polymorphisms, including two novel variants (1690G>A and 2896C>T) in the intron region and a novel non‑synonymous one (795G>C, Gln265His) were detected. CYP1A2*1A (6.77%), CYP1A2*1B (58.33%) and CYP1A2*1F (14.58%) were the most frequent defective alleles identified in the sample. The frequencies of the prevalent genotypes CYP1A2*1A/*1B, *1B/*1B, *1B/*1F were 13.54%, 16.67% and 29.17%, respectively. In addition, the novel non‑synonymous variant 795G>C (Gln265His) was predicted to be benign by PolyPhen‑2 and SIFT tools. The present study provides useful information on the pattern of CYP1A2 polymorphisms in Chinese Tibetan population. The current results may have potential benefits for the development of personalized medicine in the Tibetan population.
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July-2017
Volume 16 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Ren Y, Liu F, Shi X, Geng T, Yuan D, Wang L, Kang L, Jin T and Chen C: Investigation of the major cytochrome P450 1A2 genetic variant in a healthy Tibetan population in China. Mol Med Rep 16: 573-580, 2017.
APA
Ren, Y., Liu, F., Shi, X., Geng, T., Yuan, D., Wang, L. ... Chen, C. (2017). Investigation of the major cytochrome P450 1A2 genetic variant in a healthy Tibetan population in China. Molecular Medicine Reports, 16, 573-580. https://doi.org/10.3892/mmr.2017.6645
MLA
Ren, Y., Liu, F., Shi, X., Geng, T., Yuan, D., Wang, L., Kang, L., Jin, T., Chen, C."Investigation of the major cytochrome P450 1A2 genetic variant in a healthy Tibetan population in China". Molecular Medicine Reports 16.1 (2017): 573-580.
Chicago
Ren, Y., Liu, F., Shi, X., Geng, T., Yuan, D., Wang, L., Kang, L., Jin, T., Chen, C."Investigation of the major cytochrome P450 1A2 genetic variant in a healthy Tibetan population in China". Molecular Medicine Reports 16, no. 1 (2017): 573-580. https://doi.org/10.3892/mmr.2017.6645