Unifying mechanism in the initiation of breast cancer by metabolism of estrogen (Review)

  • Authors:
    • Chunjie Wen
    • Lanxiang Wu
    • Lijuan Fu
    • Bing Wang
    • Honghao Zhou
  • View Affiliations

  • Published online on: June 9, 2017     https://doi.org/10.3892/mmr.2017.6738
  • Pages: 1001-1006
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Abstract

Excessive exposure to estrogen is associated with increased risk of breast cancer. The mechanisms of carcinogenesis in the breast caused by estrogen metabolism include formation of depurinating adducts which are released from DNA to generate apurinic sites, and production of reactive oxygen species (ROS). Excess ROS not only exerts genotoxicity by indirectly increasing genomic instability, but also stimulates progression of mammary carcinogenicity by inducing a redox‑associated signaling pathway. Estrogen metabolism enzymes serve an important role in estrogen metabolism. Alterations in the expression and activity of estrogen metabolism enzymes may influence estrogen metabolism homeostasis. The present review discusses the process of estrogen metabolism, the role of estrogen metabolites and ROS in breast carcinogenesis, and the effect of metabolism enzyme polymorphisms on generation of pro‑carcinogens and breast cancer susceptibility.
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August-2017
Volume 16 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Wen C, Wu L, Fu L, Wang B and Zhou H: Unifying mechanism in the initiation of breast cancer by metabolism of estrogen (Review). Mol Med Rep 16: 1001-1006, 2017
APA
Wen, C., Wu, L., Fu, L., Wang, B., & Zhou, H. (2017). Unifying mechanism in the initiation of breast cancer by metabolism of estrogen (Review). Molecular Medicine Reports, 16, 1001-1006. https://doi.org/10.3892/mmr.2017.6738
MLA
Wen, C., Wu, L., Fu, L., Wang, B., Zhou, H."Unifying mechanism in the initiation of breast cancer by metabolism of estrogen (Review)". Molecular Medicine Reports 16.2 (2017): 1001-1006.
Chicago
Wen, C., Wu, L., Fu, L., Wang, B., Zhou, H."Unifying mechanism in the initiation of breast cancer by metabolism of estrogen (Review)". Molecular Medicine Reports 16, no. 2 (2017): 1001-1006. https://doi.org/10.3892/mmr.2017.6738